Hb40-61a: Novel analogues help expanding the knowledge on chemistry, properties and candidacidal action of this bovine α-hemoglobin-derived peptide
This study expands the knowledge on chemical synthesis and properties of Hb40-61a as well as provides results of the first steps given towards knowing how it kills Candida cells. For the first time, this peptide, its all-D analogue (D-Hb40-61a) and its fluorescently labeled analogue (FAM-Hb40-61a) w...
Saved in:
Published in | Biochimica et biophysica acta Vol. 1848; no. 12; pp. 3140 - 3149 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.12.2015
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | This study expands the knowledge on chemical synthesis and properties of Hb40-61a as well as provides results of the first steps given towards knowing how it kills Candida cells. For the first time, this peptide, its all-D analogue (D-Hb40-61a) and its fluorescently labeled analogue (FAM-Hb40-61a) were successfully assembled on resin at 60°C using conventional heating in all steps. Purified and characterized, these peptides exhibited very low toxicity on human erythrocytes. Hb40-61a and D-Hb40-61a were equally active against Candida strains, ruling out sterically specific interactions on their working mechanism. Cell permeabilization assays confirmed progressive damage of the yeast plasma membrane with increasing concentrations of Hb40-61a. While experiment using the fluorescent probe DiBAC4(5) revealed that this synthetic hemocidin alters the yeast plasma membrane potential, test employing DPH indicated that Hb40-61a might affect its dynamics. Exposure of the yeast cells to FAM-Hb40-61a showed that the peptide accumulates in the cell membrane at the ½ MIC, but stains about 97% of the cells at the MIC. Such effect is salt-dependent and partially energy-dependent. These new findings indicate that the central target of Hb40-61a in Candida cells is the plasma membrane and that this synthetic hemocidin should be considered as a potential candidacidal for topic uses.
[Display omitted]
•We expanded the knowledge on synthetic hemocidins derived from bovine α-hemoglobin.•We first describe productive, fast and relatively clean syntheses of Hb40-61a and analogues using high temperature.•We first show that, likewise Hb40-61a, its D-isomer and its fluorescently labeled analogue inhibit the growth of Candida strains.•We first show that the low hemolytic Hb40-61a acts through a non-quiral mechanism.•We first show that Hb40-61a damages Candida cell plasma membrane altering its permeability, potential and dynamics.•We first show that Candida plasma membrane is the first and ultimate target of Hb40-61a. |
---|---|
AbstractList | This study expands the knowledge on chemical synthesis and properties of Hb40-61a as well as provides results of the first steps given towards knowing how it kills Candida cells. For the first time, this peptide, its all-D analogue (D-Hb40-61a) and its fluorescently labeled analogue (FAM-Hb40-61a) were successfully assembled on resin at 60°C using conventional heating in all steps. Purified and characterized, these peptides exhibited very low toxicity on human erythrocytes. Hb40-61a and D-Hb40-61a were equally active against Candida strains, ruling out sterically specific interactions on their working mechanism. Cell permeabilization assays confirmed progressive damage of the yeast plasma membrane with increasing concentrations of Hb40-61a. While experiment using the fluorescent probe DiBAC4(5) revealed that this synthetic hemocidin alters the yeast plasma membrane potential, test employing DPH indicated that Hb40-61a might affect its dynamics. Exposure of the yeast cells to FAM-Hb40-61a showed that the peptide accumulates in the cell membrane at the ½ MIC, but stains about 97% of the cells at the MIC. Such effect is salt-dependent and partially energy-dependent. These new findings indicate that the central target of Hb40-61a in Candida cells is the plasma membrane and that this synthetic hemocidin should be considered as a potential candidacidal for topic uses.
[Display omitted]
•We expanded the knowledge on synthetic hemocidins derived from bovine α-hemoglobin.•We first describe productive, fast and relatively clean syntheses of Hb40-61a and analogues using high temperature.•We first show that, likewise Hb40-61a, its D-isomer and its fluorescently labeled analogue inhibit the growth of Candida strains.•We first show that the low hemolytic Hb40-61a acts through a non-quiral mechanism.•We first show that Hb40-61a damages Candida cell plasma membrane altering its permeability, potential and dynamics.•We first show that Candida plasma membrane is the first and ultimate target of Hb40-61a. This study expands the knowledge on chemical synthesis and properties of Hb40-61a as well as provides results of the first steps given towards knowing how it kills Candida cells. For the first time, this peptide, its all-D analogue (D-Hb40-61a) and its fluorescently labeled analogue (FAM-Hb40-61a) were successfully assembled on resin at 60°C using conventional heating in all steps. Purified and characterized, these peptides exhibited very low toxicity on human erythrocytes. Hb40-61a and D-Hb40-61a were equally active against Candida strains, ruling out sterically specific interactions on their working mechanism. Cell permeabilization assays confirmed progressive damage of the yeast plasma membrane with increasing concentrations of Hb40-61a. While experiment using the fluorescent probe DiBAC4(5) revealed that this synthetic hemocidin alters the yeast plasma membrane potential, test employing DPH indicated that Hb40-61a might affect its dynamics. Exposure of the yeast cells to FAM-Hb40-61a showed that the peptide accumulates in the cell membrane at the ½ MIC, but stains about 97% of the cells at the MIC. Such effect is salt-dependent and partially energy-dependent. These new findings indicate that the central target of Hb40-61a in Candida cells is the plasma membrane and that this synthetic hemocidin should be considered as a potential candidacidal for topic uses. |
Author | Perez, K.R. Carvalho, L.A.C. Remuzgo, C. Machini, M.T. |
Author_xml | – sequence: 1 givenname: L.A.C. surname: Carvalho fullname: Carvalho, L.A.C. organization: Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil – sequence: 2 givenname: C. surname: Remuzgo fullname: Remuzgo, C. organization: Special Laboratory of Pain and Signaling, Butantan Institute, São Paulo, Brazil – sequence: 3 givenname: K.R. surname: Perez fullname: Perez, K.R. organization: Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil – sequence: 4 givenname: M.T. surname: Machini fullname: Machini, M.T. email: mtmachini@iq.usp.br organization: Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26367061$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kE1uFDEQRi2UiEwCN0DIB6CbstvdnmaBhCKSIEVhA2vLP-UZD912y92ZkHtwES6SM8WjAZYsSrX53leld05OYopIyBsGNQPWvd_VxugRx5oDa2voa2DwgqzYWvYV7wQ_ISsAaCsum-6MnM_zDgomePuSnPGu6SR0bEV-3RgBVcf0B3qX9jhQHfWQNvc40y0OE8Wfk44uxA1dtkh_xPQwoNsgTZHaLY5hXvLjOzrlNGFeQqFKmtoD4rQtUwrtEko6-dIQZmrSPkSkT7-rgqfNkEyIlcMc9ujohNMSHL4ip14PM77-sy_I96vP3y5vqtuv118uP91WVsB6qTxvdCuY7v3aN0ZLCc6Dl4wZzqXgnqMXANIILvuWc_C-4XrNOe8brYVrmwsijr02p3nO6NWUw6jzo2KgDpLVTh0lq4NkBb0qkgv29ohN92ZE9w_6a7UEPh4DWJ7fB8xqtgGjRRcy2kW5FP5_4RmT0JN9 |
CitedBy_id | crossref_primary_10_4155_fmc_2016_0035 crossref_primary_10_1007_s00018_016_2326_7 crossref_primary_10_3390_ani13040744 crossref_primary_10_1021_acsomega_7b01127 crossref_primary_10_1007_s00203_020_01959_z crossref_primary_10_3389_fmicb_2019_01703 |
Cites_doi | 10.1086/524071 10.1074/jbc.274.36.25330 10.1016/j.tet.2004.03.070 10.1021/jm020543e 10.1128/AAC.37.9.1962 10.1093/humrep/den318 10.1086/513615 10.1021/bi0475323 10.1007/s00726-014-1811-2 10.1021/bi00164a017 10.1093/cid/cir120 10.1016/j.peptides.2008.01.011 10.1016/j.bbamem.2008.09.013 10.1016/S1570-0232(03)00245-9 10.1016/S0968-0896(00)00263-7 10.1080/00365540701765657 10.1086/500939 10.1128/AAC.42.12.3065 10.1529/biophysj.105.067595 10.1016/j.drup.2007.04.002 10.1038/nbt1267 10.1016/j.peptides.2004.06.015 10.1002/(SICI)1097-0282(1998)47:6<451::AID-BIP4>3.0.CO;2-F 10.1016/j.bbamem.2009.06.008 10.1074/jbc.M300680200 10.1111/j.1399-3011.1997.tb01175.x 10.1016/j.it.2008.12.003 10.1074/jbc.M610555200 10.1111/j.1742-4658.2011.08302.x 10.1016/j.bbamem.2007.06.020 10.2741/3194 10.1603/0022-2585-40.1.78 10.1016/j.peptides.2006.03.015 10.1016/j.coph.2006.04.006 10.3109/08923973.2012.692380 10.1016/S0014-5793(01)02171-8 10.1016/j.peptides.2006.03.033 10.1039/c2cp43099a 10.1128/CMR.00029-06 10.1590/S0001-37652009000300020 10.1023/A:1002081605784 10.1016/j.peptides.2004.12.008 10.1590/S0100-40422013000700017 10.1016/j.bbamem.2009.08.018 10.1016/j.ijbiomac.2011.04.004 10.1016/j.tetlet.2004.05.081 10.1016/j.peptides.2011.05.021 10.1128/JCM.00773-06 10.1002/bip.20688 10.1186/1756-3305-3-63 10.1128/IAI.65.7.2898-2903.1997 10.1016/0005-2728(67)90002-3 10.1007/978-0-387-73657-0_75 10.1007/s11274-010-0514-4 10.1093/cid/cis021 10.1128/JB.108.1.69-73.1971 10.1086/591033 10.1128/AAC.00585-12 10.2119/molmed.2008.00087 |
ContentType | Journal Article |
Copyright | 2015 Elsevier B.V. Copyright © 2015 Elsevier B.V. All rights reserved. |
Copyright_xml | – notice: 2015 Elsevier B.V. – notice: Copyright © 2015 Elsevier B.V. All rights reserved. |
DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION |
DOI | 10.1016/j.bbamem.2015.09.010 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Chemistry Biology |
EISSN | 1879-2642 1878-2434 |
EndPage | 3149 |
ExternalDocumentID | 10_1016_j_bbamem_2015_09_010 26367061 S0005273615002953 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 6I. 6J9 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABEFU ABFNM ABGSF ABMAC ABUDA ABVKL ABXDB ABYKQ ACDAQ ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AEXQZ AFKWA AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q G8K GBLVA HLW HVGLF HZ~ IHE IXB J1W KOM LX3 M41 MO0 N9A NCXOZ O-L O9- OAUVE OK1 OZT P-8 P-9 PC. Q38 R2- RIG ROL RPZ RSU SBG SCC SDF SDG SDP SES SEW SSU SSZ T5K WH7 WUQ XJT XPP ~G- -~X .55 .GJ AAYJJ ABJNI AFFNX AI. AKRWK CGR CUY CVF ECM EIF F5P H~9 K-O MVM NPM OHT TWZ UHS VH1 X7M XFK Y6R YYP ZE2 ZGI ~KM 0SF AAXKI AAYXX ADVLN CITATION |
ID | FETCH-LOGICAL-c408t-f23a541a9f8f3ba770df0f711b22742f2ef4007b42795220ff32a822293aa4d53 |
IEDL.DBID | IXB |
ISSN | 0005-2736 0006-3002 |
IngestDate | Thu Sep 12 19:54:51 EDT 2024 Thu May 23 23:22:48 EDT 2024 Fri Feb 23 02:33:57 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 12 |
Keywords | Hemoglobin-derived peptides Membrane permeabilization Peptide synthesis at 60°C Fungicidal action Hemocidins Antimicrobial peptides |
Language | English |
License | http://www.elsevier.com/open-access/userlicense/1.0 Copyright © 2015 Elsevier B.V. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c408t-f23a541a9f8f3ba770df0f711b22742f2ef4007b42795220ff32a822293aa4d53 |
OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0005273615002953 |
PMID | 26367061 |
PageCount | 10 |
ParticipantIDs | crossref_primary_10_1016_j_bbamem_2015_09_010 pubmed_primary_26367061 elsevier_sciencedirect_doi_10_1016_j_bbamem_2015_09_010 |
PublicationCentury | 2000 |
PublicationDate | December 2015 2015-Dec 2015-12-00 |
PublicationDateYYYYMMDD | 2015-12-01 |
PublicationDate_xml | – month: 12 year: 2015 text: December 2015 |
PublicationDecade | 2010 |
PublicationPlace | Netherlands |
PublicationPlace_xml | – name: Netherlands |
PublicationTitle | Biochimica et biophysica acta |
PublicationTitleAlternate | Biochim Biophys Acta |
PublicationYear | 2015 |
Publisher | Elsevier B.V |
Publisher_xml | – name: Elsevier B.V |
References | Loffredo, Assunção, Miranda (bb0230) 2009; 611 Sheshadri, Abraham (bb0115) 2012; 34 Mak, Wójcik, Wicherek, Suder, Dubin (bb0175) 2004; 25 Park, Lee (bb0285) 2009; 1788 Parish, Jiang, Tokiwa, Berova, Nakanishi, Mccabe, Zuckerman, Xia, Gabay (bb0125) 2001; 9 Lee, Cho, Lehrer (bb0280) 1997; 65 Li, Reddy, Baev, Edgerton (bb0270) 2003; 278 Varanda, Miranda (bb0220) 1997; 50 Hansen, Schafer, Knappe, Seibel, Hoffmann (bb0275) 2012; 56 Rossi (bb0045) 2011; 52 Hu, Xu, Hang, Wang, Wang, Chen, Song, Fu, Wang, Wang, Liu (bb0190) 2011; 27 Y. Kushnareva, Membrane Fluidity Measurements Using UV Fluorescence Polarization and the POLARstar Omega. BMG Labtec Application Note 205, Rev. 12/2009. Colombo, Janini, Salomão, Medeiros, Wey, Pignatari (bb0020) 2009; 81 Andes, Safdar, Baddley, Playford, Reboli, Rex, Sobel, Pappas, Kullberg (bb0025) 2012; 54 Kanafani, Perfect (bb0035) 2008; 46 Cruz, Fogaça, Nakayasu, Angeli, Belmonte, Almeida, Miranda, Miranda, Tanaka, Braz, Craik, Schneider, Caffrey, Daffre (bb0195) 2010; 3 Kiyota, Franzoni, Nicastro, Benedetti, Oyama, Viviani, Gambarini, Spisni, Miranda (bb0240) 2003; 46 Wilson, Chance (bb0290) 1967; 131 Matsuzaki (bb0080) 2009; 1788 Oren, Shai (bb0265) 1998; 47 Tharp, Ackermann, Gallup, Brogden (bb0170) 2007 Nedjar-Arroume, Dudois-Delval, Adje, Traisnel, Krier, Mary, Kouach, Briand, Guillochon (bb0145) 2008; 29 Mak, Wójcik, Silberring, Dubin (bb0105) 2000; 77 Colombo, Guimarães, Silva, De Almeida Monfardini, Cunha, Rady, Alves, Rosas (bb0040) 2007; 28 Deng, Pan, Wang, Wang, Zhou, Li, Feng, Wu, Wang, Huang (bb0185) 2009; 24 Cederlund, Gudmundsson, Agerberth (bb0100) 2011; 278 Pfaller, Diekema (bb0010) 2007; 20 Hitchcock, Pye, Troke, Johnson, Warnock (bb0055) 1993; 37 Samonis, Kofteridis, Saloustros, Giannopoulou, Ntziora, Christidou, Maraki, Falagas (bb0030) 2008; 40 Froidevaux, Krier, Nedjar-arroume, Vercaigne-Marko, Kosciarz, Ruckebusch, Dhulster, Guillochon (bb0130) 2001; 491 Hancock, Sahl (bb0095) 2006; 24 Krogh-Madsen, Arendrup, Heslet, Knudsen (bb0050) 2006; 42 Fernández-Carneado, Giralt (bb0235) 2004; 45 Lai, Gallo (bb0085) 2009; 30 Zilberberg, Shorr, Kollef (bb0005) 2008; 29 Sai, Kajita, Tamai, Wakama, Wakamiya, Tsuji (bb0300) 1998; 275 Neville, Cahuzac, Konovalov, Ishitsuka, Lee, Kuzmenko, Kale, Gidalevitz (bb0315) 2006; 90 Pálffy, Gardlík, Behuliak, Kadasi, Turna, Celec (bb0320) 2009; 15 Colombo, Nucci, Park, Nouer, Arthington-Skaggs, Matta, Warnock, Morgan (bb0015) 2006; 44 Chekmenev, Vollmar, Cotton (bb0075) 2010; 1798 Veerman, Valentin-Benz, Nazmi, Ruissen, Walgreen-Weterings, van Marle, Doust, van't Hof, Bolscher, Amerongen (bb0295) 2007; 282 Nedjar-Arroume, Dubois-Delval, Miloudi, Daoud, Krier, Kouach, Briand, Guillochon (bb0140) 2006; 27 Souza, Tavares, Miranda (bb0225) 2004; 60 Woods (bb0070) 1971; 108 Liepke, Baxmann, Heine, Breithaupt, Standker, Forssmann (bb0160) 2003; 791 Mak (bb0110) 2008; 13 Nakajima, Ogihara, Taylor, Yamakawa (bb0165) 2003; 40 Remuzgo, Oewel, Daffre, Lopes, Dyszy, Schreier, Machado-Santelli, Machini (bb0250) 2014; 46 Marr, Gooderham, Hancock (bb0090) 2006; 6 Won, Jung, Kim, Seo, Lee (bb0210) 2004; 279 Daoud, Dubois, Bors-Dodita, Nedjar-Arroume, Krier, Chihib, Mary, Kouach, Briand, Guillochon (bb0135) 2005; 26 Kacprzy, Rydengard, Morgelin, Davoudi, Pasupuleti, Malmsten, Schmidtchen (bb0245) 2007; 1768 Perlin (bb0065) 2007; 10 Sforça, Machado, Figueredo, Oyama, Silva, Miranda, Daffre, Miranda, Spisni, Pertinhez (bb0205) 2005; 44 Fernandez, Le Brun, Whitwell, Sani, James, Separovic (bb0310) 2012; 14 Adje, Balti, Kouach, Dhulster, Guillochon, Nedjar-Arroume (bb0155) 2011; 49 Pouny, Rapaport, Mor, Nicolas, Shai (bb0305) 1992; 31 Machado, Sforça, Miranda, Daffre, Pertinhez, Spisni, Miranda (bb0215) 2007; 88 Clinical and Laboratory Standards Institute (bb0260) 2008 Franz, Kelly, Lamb, Kelly, Ruhnke, Morschhauser (bb0060) 1998; 42 Catiau, Traisnel, Chihib, Le Flem, Blanpain, Melnyl, Guillochon, Nedjar-Arroume (bb0150) 2011; 32 Carvalho, Machini (bb0200) 2013; 36 Fogaça, da Silva Jr, Miranda, Bianchi, Miranda, Ribolla, Daffre (bb0120) 1999; 274 Brown, Leite, Engler, Discher, Strauss (bb0180) 2006; 27 Lee (10.1016/j.bbamem.2015.09.010_bb0280) 1997; 65 Veerman (10.1016/j.bbamem.2015.09.010_bb0295) 2007; 282 Zilberberg (10.1016/j.bbamem.2015.09.010_bb0005) 2008; 29 Hitchcock (10.1016/j.bbamem.2015.09.010_bb0055) 1993; 37 Liepke (10.1016/j.bbamem.2015.09.010_bb0160) 2003; 791 Brown (10.1016/j.bbamem.2015.09.010_bb0180) 2006; 27 Tharp (10.1016/j.bbamem.2015.09.010_bb0170) 2007 Deng (10.1016/j.bbamem.2015.09.010_bb0185) 2009; 24 Krogh-Madsen (10.1016/j.bbamem.2015.09.010_bb0050) 2006; 42 Matsuzaki (10.1016/j.bbamem.2015.09.010_bb0080) 2009; 1788 Mak (10.1016/j.bbamem.2015.09.010_bb0175) 2004; 25 Fernández-Carneado (10.1016/j.bbamem.2015.09.010_bb0235) 2004; 45 Park (10.1016/j.bbamem.2015.09.010_bb0285) 2009; 1788 Rossi (10.1016/j.bbamem.2015.09.010_bb0045) 2011; 52 Chekmenev (10.1016/j.bbamem.2015.09.010_bb0075) 2010; 1798 Hu (10.1016/j.bbamem.2015.09.010_bb0190) 2011; 27 Wilson (10.1016/j.bbamem.2015.09.010_bb0290) 1967; 131 Kanafani (10.1016/j.bbamem.2015.09.010_bb0035) 2008; 46 Clinical and Laboratory Standards Institute (10.1016/j.bbamem.2015.09.010_bb0260) 2008 Machado (10.1016/j.bbamem.2015.09.010_bb0215) 2007; 88 Sheshadri (10.1016/j.bbamem.2015.09.010_bb0115) 2012; 34 Oren (10.1016/j.bbamem.2015.09.010_bb0265) 1998; 47 Samonis (10.1016/j.bbamem.2015.09.010_bb0030) 2008; 40 Pouny (10.1016/j.bbamem.2015.09.010_bb0305) 1992; 31 Remuzgo (10.1016/j.bbamem.2015.09.010_bb0250) 2014; 46 Catiau (10.1016/j.bbamem.2015.09.010_bb0150) 2011; 32 Won (10.1016/j.bbamem.2015.09.010_bb0210) 2004; 279 Colombo (10.1016/j.bbamem.2015.09.010_bb0040) 2007; 28 Mak (10.1016/j.bbamem.2015.09.010_bb0110) 2008; 13 Nakajima (10.1016/j.bbamem.2015.09.010_bb0165) 2003; 40 Carvalho (10.1016/j.bbamem.2015.09.010_bb0200) 2013; 36 Loffredo (10.1016/j.bbamem.2015.09.010_bb0230) 2009; 611 Froidevaux (10.1016/j.bbamem.2015.09.010_bb0130) 2001; 491 Hansen (10.1016/j.bbamem.2015.09.010_bb0275) 2012; 56 Kiyota (10.1016/j.bbamem.2015.09.010_bb0240) 2003; 46 Varanda (10.1016/j.bbamem.2015.09.010_bb0220) 1997; 50 Neville (10.1016/j.bbamem.2015.09.010_bb0315) 2006; 90 Marr (10.1016/j.bbamem.2015.09.010_bb0090) 2006; 6 Daoud (10.1016/j.bbamem.2015.09.010_bb0135) 2005; 26 Perlin (10.1016/j.bbamem.2015.09.010_bb0065) 2007; 10 Kacprzy (10.1016/j.bbamem.2015.09.010_bb0245) 2007; 1768 Andes (10.1016/j.bbamem.2015.09.010_bb0025) 2012; 54 Adje (10.1016/j.bbamem.2015.09.010_bb0155) 2011; 49 Sforça (10.1016/j.bbamem.2015.09.010_bb0205) 2005; 44 Nedjar-Arroume (10.1016/j.bbamem.2015.09.010_bb0140) 2006; 27 Lai (10.1016/j.bbamem.2015.09.010_bb0085) 2009; 30 Fogaça (10.1016/j.bbamem.2015.09.010_bb0120) 1999; 274 Souza (10.1016/j.bbamem.2015.09.010_bb0225) 2004; 60 Woods (10.1016/j.bbamem.2015.09.010_bb0070) 1971; 108 Fernandez (10.1016/j.bbamem.2015.09.010_bb0310) 2012; 14 Pálffy (10.1016/j.bbamem.2015.09.010_bb0320) 2009; 15 Colombo (10.1016/j.bbamem.2015.09.010_bb0020) 2009; 81 Franz (10.1016/j.bbamem.2015.09.010_bb0060) 1998; 42 10.1016/j.bbamem.2015.09.010_bb0255 Pfaller (10.1016/j.bbamem.2015.09.010_bb0010) 2007; 20 Hancock (10.1016/j.bbamem.2015.09.010_bb0095) 2006; 24 Colombo (10.1016/j.bbamem.2015.09.010_bb0015) 2006; 44 Nedjar-Arroume (10.1016/j.bbamem.2015.09.010_bb0145) 2008; 29 Parish (10.1016/j.bbamem.2015.09.010_bb0125) 2001; 9 Cederlund (10.1016/j.bbamem.2015.09.010_bb0100) 2011; 278 Mak (10.1016/j.bbamem.2015.09.010_bb0105) 2000; 77 Li (10.1016/j.bbamem.2015.09.010_bb0270) 2003; 278 Cruz (10.1016/j.bbamem.2015.09.010_bb0195) 2010; 3 Sai (10.1016/j.bbamem.2015.09.010_bb0300) 1998; 275 |
References_xml | – volume: 131 start-page: 421 year: 1967 end-page: 430 ident: bb0290 article-title: Azide inhibition of mitochondrial eletron transport. I. The aerobic steady state of succinate oxidation publication-title: Biochim. Biophys. Acta contributor: fullname: Chance – volume: 275 start-page: G514 year: 1998 end-page: G520 ident: bb0300 article-title: Adsorptive-mediated endocytosis of a basic peptide in enterocyte-like caco-2 cells publication-title: Am. J. Phys. contributor: fullname: Tsuji – volume: 10 start-page: 121 year: 2007 end-page: 130 ident: bb0065 article-title: Resistance to echinocandin-class antifungal drugs publication-title: Drug Resist. Updat. contributor: fullname: Perlin – volume: 27 start-page: 767 year: 2011 end-page: 771 ident: bb0190 article-title: Isolation and characterization of an antimicrobial peptide from bovine hemoglobin α-subunit publication-title: World J. Microbiol. Biotechnol. contributor: fullname: Liu – volume: 34 start-page: 896 year: 2012 end-page: 900 ident: bb0115 article-title: Antimicrobial properties of hemoglobin publication-title: Immunopharmacol. Immunotoxicol. contributor: fullname: Abraham – volume: 24 start-page: 211 year: 2009 end-page: 218 ident: bb0185 article-title: Hemoglobin and its derived peptides may play a role in the antibacterial mechanism of the vagina publication-title: Hum. Reprod. contributor: fullname: Huang – volume: 282 start-page: 18831 year: 2007 end-page: 18841 ident: bb0295 article-title: Energy depletion protects publication-title: J. Biol. Chem. contributor: fullname: Amerongen – volume: 32 start-page: 1463 year: 2011 end-page: 1468 ident: bb0150 article-title: RYH: a minimal peptidic sequence obtained from α-chain hemoglobin exhibiting an antimicrobial activity publication-title: Peptides contributor: fullname: Nedjar-Arroume – volume: 3 start-page: 63 year: 2010 end-page: 78 ident: bb0195 article-title: Characterization of proteinases from the midgut of publication-title: Parasit. Vectors contributor: fullname: Daffre – volume: 14 start-page: 15739 year: 2012 end-page: 15751 ident: bb0310 article-title: The antimicrobial peptide aurein 1.2 disrupts model membranes via the carpet mechanism publication-title: Phys. Chem. Chem. Phys. contributor: fullname: Separovic – volume: 52 start-page: 1138 year: 2011 end-page: 1143 ident: bb0045 article-title: The challenges of antimicrobial resistance in Brazil publication-title: Clin. Infect. Dis. contributor: fullname: Rossi – volume: 49 start-page: 143 year: 2011 end-page: 153 ident: bb0155 article-title: Obtaining antimicrobial peptides by controlled peptic hydrolysis of bovine hemoglobin publication-title: Int. J. Biol. Macromol. contributor: fullname: Nedjar-Arroume – volume: 42 start-page: 3056 year: 1998 end-page: 3072 ident: bb0060 article-title: Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical publication-title: Antimicrob. Agents Chemother. contributor: fullname: Morschhauser – volume: 56 start-page: 5194 year: 2012 end-page: 5201 ident: bb0275 article-title: Intracellular toxicity of proline-rich antimicrobial peptides shuttled into mammalian cells by the cell-penetrating peptide penetratin publication-title: Antimicrob. Agents Chemother. contributor: fullname: Hoffmann – volume: 9 start-page: 377 year: 2001 end-page: 382 ident: bb0125 article-title: Broad-spectrum antimicrobial activity of hemoglobin publication-title: Bioorg. Med. Chem. contributor: fullname: Gabay – volume: 37 start-page: 1962 year: 1993 end-page: 1965 ident: bb0055 article-title: Fluconazole resistance in publication-title: Antimicrob. Agents Chemother. contributor: fullname: Warnock – volume: 27 start-page: 1794 year: 2006 end-page: 1800 ident: bb0180 article-title: A hemoglobin fragment found in cervicovaginal fluid from women in labor potentiates the action of agents that promote contraction of smooth muscle cells publication-title: Peptides contributor: fullname: Strauss – volume: 29 start-page: 969 year: 2008 end-page: 977 ident: bb0145 article-title: Bovine hemoglobin: an attractive source of antibacterial peptides publication-title: Peptides contributor: fullname: Guillochon – volume: 791 start-page: 345 year: 2003 end-page: 356 ident: bb0160 article-title: Human hemoglobin-derived peptides exhibit antimicrobial activity: a class of host defense peptides publication-title: J. Chromatogr. B contributor: fullname: Forssmann – volume: 44 start-page: 6440 year: 2005 end-page: 6451 ident: bb0205 article-title: The micelle-bound structure of an antimicrobial peptide derived from the alpha-chain of bovine hemoglobin isolated from the tick publication-title: Biochemistry contributor: fullname: Pertinhez – year: 2008 ident: bb0260 article-title: Reference method for broth dilution antifungal susceptibility testing of yeasts; Approved standard publication-title: CLSI document M27-A3 contributor: fullname: Clinical and Laboratory Standards Institute – volume: 24 start-page: 1551 year: 2006 end-page: 1557 ident: bb0095 article-title: Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies publication-title: Nat. Biotechnol. contributor: fullname: Sahl – volume: 36 start-page: 1021 year: 2013 end-page: 1029 ident: bb0200 article-title: Hemocidins derived from hemoglobin: structures, properties and perspectives publication-title: Quim. Nova contributor: fullname: Machini – volume: 45 start-page: 6079 year: 2004 end-page: 6081 ident: bb0235 article-title: An efficient method for the solid-phase synthesis of fluorescently labelled peptides publication-title: Tetrahedron Lett. contributor: fullname: Giralt – volume: 20 start-page: 133 year: 2007 end-page: 163 ident: bb0010 article-title: Epidemiology of invasive candidiasis a persistent public health problem publication-title: Clin. Microbiol. Rev. contributor: fullname: Diekema – volume: 47 start-page: 451 year: 1998 end-page: 463 ident: bb0265 article-title: Mode of action of linear amphipathic α-helical antimicrobial peptide publication-title: Biopolymers contributor: fullname: Shai – volume: 6 start-page: 468 year: 2006 end-page: 472 ident: bb0090 article-title: Antibacterial peptides for the therapeutic use: obstacles and realistic outlook publication-title: Curr. Opin. Pharmacol. contributor: fullname: Hancock – volume: 77 start-page: 197 year: 2000 end-page: 207 ident: bb0105 article-title: Antimicrobial peptides derived from heme-containing proteins: hemocidins publication-title: Antonie Van Leeuwenhoek contributor: fullname: Dubin – volume: 13 start-page: 6859 year: 2008 end-page: 6871 ident: bb0110 article-title: Hemocidins in a functional and structural context of juman antimicrobial peptides publication-title: Front. Biosci. contributor: fullname: Mak – volume: 54 start-page: 1110 year: 2012 end-page: 1122 ident: bb0025 article-title: Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials publication-title: Clin. Infect. Dis. contributor: fullname: Kullberg – volume: 15 start-page: 51 year: 2009 end-page: 59 ident: bb0320 article-title: On the physiology and pathophysiology of antimicrobial peptide publication-title: Mol. Med. contributor: fullname: Celec – volume: 90 start-page: 1275 year: 2006 end-page: 1287 ident: bb0315 article-title: Lipid headgroup discrimination by antimicrobial peptide LL-37: insight into mechanism of action publication-title: Biophys. J. contributor: fullname: Gidalevitz – volume: 28 start-page: 570 year: 2007 end-page: 576 ident: bb0040 article-title: Prospective observational study of candidemia in São Paulo, Brazil: incidence rate, epidemiology and predictors of mortality publication-title: Infect. Control Hosp. Epidemiol. contributor: fullname: Rosas – volume: 40 start-page: 78 year: 2003 end-page: 81 ident: bb0165 article-title: Antibacterial hemoglobin fragments from the midgut of the soft tick, publication-title: J. Med. Entomol. contributor: fullname: Yamakawa – volume: 611 start-page: 165 year: 2009 end-page: 166 ident: bb0230 article-title: Further studies on peptide synthesis on high temperature. Peptides for Youth publication-title: Adv. Exp. Med. Biol. contributor: fullname: Miranda – volume: 31 start-page: 12416 year: 1992 end-page: 12423 ident: bb0305 article-title: Interaction of antimicrobial dermaseptin and its fluorescently labeled analogs with phospholipid membranes publication-title: Biochemistry contributor: fullname: Shai – volume: 274 start-page: 25330 year: 1999 end-page: 25334 ident: bb0120 article-title: Antimicrobial activity of a bovine hemoglobin fragment in the tick publication-title: J. Biol. Chem. contributor: fullname: Daffre – volume: 65 start-page: 2898 year: 1997 end-page: 2903 ident: bb0280 article-title: Effects of pH and salinity on the antimicrobial properties of clavanins publication-title: Infect. Immun. contributor: fullname: Lehrer – year: 2007 ident: bb0170 article-title: An ovine hemoglobin fragment inhibits publication-title: The IADR/AADR/CADR 85th General Session and Exhibition. New Orleans, LA. contributor: fullname: Brogden – volume: 491 start-page: 159 year: 2001 end-page: 163 ident: bb0130 article-title: Antibacterial activity of a pepsin-derived bovine hemoglobin fragment publication-title: FEBS Lett. contributor: fullname: Guillochon – volume: 1788 start-page: 1790 year: 2009 end-page: 1796 ident: bb0285 article-title: Fungicidal effect of antimicrobial peptide arenicin-1 publication-title: Biochim. Biophys. Acta contributor: fullname: Lee – volume: 29 start-page: 978 year: 2008 end-page: 980 ident: bb0005 article-title: Secular trends in candidiasis related hospitalization in the United States publication-title: Infect. Control Hosp. Epidemiol. contributor: fullname: Kollef – volume: 42 start-page: 938 year: 2006 end-page: 944 ident: bb0050 article-title: Amphotericin B and caspofungin resistance in publication-title: Clin. Infect. Dis. contributor: fullname: Knudsen – volume: 46 start-page: 2573 year: 2014 end-page: 2586 ident: bb0250 article-title: Chemical synthesis, structure–activity relationship and properties of shepherin I: a fungicidal peptide enriched in glycine–glycine–histidine motifs publication-title: Amino Acids contributor: fullname: Machini – volume: 26 start-page: 713 year: 2005 end-page: 719 ident: bb0135 article-title: New antibacterial peptide derived from bovine hemoglobin publication-title: Peptides contributor: fullname: Guillochon – volume: 108 start-page: 69 year: 1971 end-page: 73 ident: bb0070 article-title: Nystatin-resistance mutants of yeast: alterations in sterol content publication-title: J. Bacteriol. contributor: fullname: Woods – volume: 1788 start-page: 1687 year: 2009 end-page: 1692 ident: bb0080 article-title: Control of cell selectivity of antimicrobial peptides publication-title: Biochim. Biophys. Acta contributor: fullname: Matsuzaki – volume: 88 start-page: 413 year: 2007 end-page: 426 ident: bb0215 article-title: Truncation of amidated fragment 33–61 of bovine alpha-hemoglobin: effects on the structure and anticandidal activity publication-title: Biopolymers contributor: fullname: Miranda – volume: 278 start-page: 28553 year: 2003 end-page: 28561 ident: bb0270 article-title: Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5 publication-title: J. Biol. Chem. contributor: fullname: Edgerton – volume: 1798 start-page: 228 year: 2010 end-page: 234 ident: bb0075 article-title: Can antimicrobial peptides scavenge around a cell in less than a Second? publication-title: Biochim. Biophys. Acta contributor: fullname: Cotton – volume: 46 start-page: 120 year: 2008 end-page: 128 ident: bb0035 article-title: Antimicrobial resistance to antifungal agents: mechanisms and clinical impact publication-title: Clin. Infect. Dis. contributor: fullname: Perfect – volume: 278 start-page: 3942 year: 2011 end-page: 3947 ident: bb0100 article-title: Antimicrobial peptides important in innate immunity publication-title: FEBS J. contributor: fullname: Agerberth – volume: 27 start-page: 2082 year: 2006 end-page: 2089 ident: bb0140 article-title: Isolation and characterization of four antibacterial peptides from bovine hemoglobin publication-title: Peptides contributor: fullname: Guillochon – volume: 44 start-page: 2816 year: 2006 end-page: 2823 ident: bb0015 article-title: Epidemiology of candidemia in Brazil: a nation sentinel surveillance of candidemia in eleven medical centers publication-title: J. Clin. Microbiol. contributor: fullname: Morgan – volume: 25 start-page: 1839 year: 2004 end-page: 1847 ident: bb0175 article-title: Antibacterial hemoglobin peptides in human menstrual blood publication-title: Peptides contributor: fullname: Dubin – volume: 1768 start-page: 2667 year: 2007 end-page: 2680 ident: bb0245 article-title: Antimicrobial activity of histidine-rich peptides is dependent on acidic conditions publication-title: Biochim. Biophys. Acta contributor: fullname: Schmidtchen – volume: 81 start-page: 571 year: 2009 end-page: 587 ident: bb0020 article-title: Surveillance programs for detection and characterization of emergent pathogens and antimicrobial resistance publication-title: Annals Braz. Acad. Sci contributor: fullname: Pignatari – volume: 50 start-page: 102 year: 1997 end-page: 108 ident: bb0220 article-title: Solid-phase peptide synthesis at elevated temperatures: a search for and optimized synthesis condition of unsulfated cholecystokinin-12 publication-title: J. Pept. Res. contributor: fullname: Miranda – volume: 60 start-page: 4671 year: 2004 end-page: 4681 ident: bb0225 article-title: Racemization in stepwise solid-phase peptide synthesis at elevated temperatures publication-title: Tetrahedron contributor: fullname: Miranda – volume: 279 start-page: 14784 year: 2004 end-page: 14791 ident: bb0210 article-title: Systematic peptide engineering and structural characterization to search for the shortest antimicrobial peptide analogue of gaegurin 5 publication-title: J. Biolumin. Chemilumin. contributor: fullname: Lee – volume: 40 start-page: 414 year: 2008 end-page: 419 ident: bb0030 article-title: Candida albicans versus non-albicans bloodstream infection in patients in a tertiary hospital: an analysis of microbiological data publication-title: Scand. J. Infect. Dis. contributor: fullname: Falagas – volume: 46 start-page: 2325 year: 2003 end-page: 2333 ident: bb0240 article-title: Introduction of a chemical constraint in a short peptide derived from human acidic fibroblast growth factor elicits mitogenic structural determinants publication-title: J. Med. Chem. contributor: fullname: Miranda – volume: 30 start-page: 131 year: 2009 end-page: 141 ident: bb0085 article-title: AMPedup immunity: how antimicrobial peptides have multiple roles in immune defense publication-title: Trends Immunol. contributor: fullname: Gallo – volume: 46 start-page: 120 year: 2008 ident: 10.1016/j.bbamem.2015.09.010_bb0035 article-title: Antimicrobial resistance to antifungal agents: mechanisms and clinical impact publication-title: Clin. Infect. Dis. doi: 10.1086/524071 contributor: fullname: Kanafani – volume: 274 start-page: 25330 year: 1999 ident: 10.1016/j.bbamem.2015.09.010_bb0120 article-title: Antimicrobial activity of a bovine hemoglobin fragment in the tick Boophilus microplus publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.36.25330 contributor: fullname: Fogaça – volume: 60 start-page: 4671 year: 2004 ident: 10.1016/j.bbamem.2015.09.010_bb0225 article-title: Racemization in stepwise solid-phase peptide synthesis at elevated temperatures publication-title: Tetrahedron doi: 10.1016/j.tet.2004.03.070 contributor: fullname: Souza – volume: 46 start-page: 2325 year: 2003 ident: 10.1016/j.bbamem.2015.09.010_bb0240 article-title: Introduction of a chemical constraint in a short peptide derived from human acidic fibroblast growth factor elicits mitogenic structural determinants publication-title: J. Med. Chem. doi: 10.1021/jm020543e contributor: fullname: Kiyota – year: 2007 ident: 10.1016/j.bbamem.2015.09.010_bb0170 article-title: An ovine hemoglobin fragment inhibits Porphyromonas gingivalis and Micromonas micros contributor: fullname: Tharp – volume: 37 start-page: 1962 year: 1993 ident: 10.1016/j.bbamem.2015.09.010_bb0055 article-title: Fluconazole resistance in Candida glabrata publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.37.9.1962 contributor: fullname: Hitchcock – volume: 24 start-page: 211 year: 2009 ident: 10.1016/j.bbamem.2015.09.010_bb0185 article-title: Hemoglobin and its derived peptides may play a role in the antibacterial mechanism of the vagina publication-title: Hum. Reprod. doi: 10.1093/humrep/den318 contributor: fullname: Deng – volume: 28 start-page: 570 year: 2007 ident: 10.1016/j.bbamem.2015.09.010_bb0040 article-title: Prospective observational study of candidemia in São Paulo, Brazil: incidence rate, epidemiology and predictors of mortality publication-title: Infect. Control Hosp. Epidemiol. doi: 10.1086/513615 contributor: fullname: Colombo – volume: 44 start-page: 6440 year: 2005 ident: 10.1016/j.bbamem.2015.09.010_bb0205 article-title: The micelle-bound structure of an antimicrobial peptide derived from the alpha-chain of bovine hemoglobin isolated from the tick Boophilus microplus publication-title: Biochemistry doi: 10.1021/bi0475323 contributor: fullname: Sforça – volume: 46 start-page: 2573 year: 2014 ident: 10.1016/j.bbamem.2015.09.010_bb0250 article-title: Chemical synthesis, structure–activity relationship and properties of shepherin I: a fungicidal peptide enriched in glycine–glycine–histidine motifs publication-title: Amino Acids doi: 10.1007/s00726-014-1811-2 contributor: fullname: Remuzgo – volume: 31 start-page: 12416 year: 1992 ident: 10.1016/j.bbamem.2015.09.010_bb0305 article-title: Interaction of antimicrobial dermaseptin and its fluorescently labeled analogs with phospholipid membranes publication-title: Biochemistry doi: 10.1021/bi00164a017 contributor: fullname: Pouny – volume: 52 start-page: 1138 year: 2011 ident: 10.1016/j.bbamem.2015.09.010_bb0045 article-title: The challenges of antimicrobial resistance in Brazil publication-title: Clin. Infect. Dis. doi: 10.1093/cid/cir120 contributor: fullname: Rossi – volume: 29 start-page: 969 year: 2008 ident: 10.1016/j.bbamem.2015.09.010_bb0145 article-title: Bovine hemoglobin: an attractive source of antibacterial peptides publication-title: Peptides doi: 10.1016/j.peptides.2008.01.011 contributor: fullname: Nedjar-Arroume – volume: 1788 start-page: 1687 year: 2009 ident: 10.1016/j.bbamem.2015.09.010_bb0080 article-title: Control of cell selectivity of antimicrobial peptides publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamem.2008.09.013 contributor: fullname: Matsuzaki – volume: 791 start-page: 345 year: 2003 ident: 10.1016/j.bbamem.2015.09.010_bb0160 article-title: Human hemoglobin-derived peptides exhibit antimicrobial activity: a class of host defense peptides publication-title: J. Chromatogr. B doi: 10.1016/S1570-0232(03)00245-9 contributor: fullname: Liepke – volume: 9 start-page: 377 year: 2001 ident: 10.1016/j.bbamem.2015.09.010_bb0125 article-title: Broad-spectrum antimicrobial activity of hemoglobin publication-title: Bioorg. Med. Chem. doi: 10.1016/S0968-0896(00)00263-7 contributor: fullname: Parish – year: 2008 ident: 10.1016/j.bbamem.2015.09.010_bb0260 article-title: Reference method for broth dilution antifungal susceptibility testing of yeasts; Approved standard contributor: fullname: Clinical and Laboratory Standards Institute – volume: 40 start-page: 414 year: 2008 ident: 10.1016/j.bbamem.2015.09.010_bb0030 article-title: Candida albicans versus non-albicans bloodstream infection in patients in a tertiary hospital: an analysis of microbiological data publication-title: Scand. J. Infect. Dis. doi: 10.1080/00365540701765657 contributor: fullname: Samonis – volume: 42 start-page: 938 year: 2006 ident: 10.1016/j.bbamem.2015.09.010_bb0050 article-title: Amphotericin B and caspofungin resistance in Candida glabrata isolates recovered from a critically ill patient publication-title: Clin. Infect. Dis. doi: 10.1086/500939 contributor: fullname: Krogh-Madsen – volume: 42 start-page: 3056 year: 1998 ident: 10.1016/j.bbamem.2015.09.010_bb0060 article-title: Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.42.12.3065 contributor: fullname: Franz – volume: 90 start-page: 1275 year: 2006 ident: 10.1016/j.bbamem.2015.09.010_bb0315 article-title: Lipid headgroup discrimination by antimicrobial peptide LL-37: insight into mechanism of action publication-title: Biophys. J. doi: 10.1529/biophysj.105.067595 contributor: fullname: Neville – volume: 10 start-page: 121 year: 2007 ident: 10.1016/j.bbamem.2015.09.010_bb0065 article-title: Resistance to echinocandin-class antifungal drugs publication-title: Drug Resist. Updat. doi: 10.1016/j.drup.2007.04.002 contributor: fullname: Perlin – volume: 24 start-page: 1551 year: 2006 ident: 10.1016/j.bbamem.2015.09.010_bb0095 article-title: Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies publication-title: Nat. Biotechnol. doi: 10.1038/nbt1267 contributor: fullname: Hancock – volume: 25 start-page: 1839 year: 2004 ident: 10.1016/j.bbamem.2015.09.010_bb0175 article-title: Antibacterial hemoglobin peptides in human menstrual blood publication-title: Peptides doi: 10.1016/j.peptides.2004.06.015 contributor: fullname: Mak – volume: 47 start-page: 451 year: 1998 ident: 10.1016/j.bbamem.2015.09.010_bb0265 article-title: Mode of action of linear amphipathic α-helical antimicrobial peptide publication-title: Biopolymers doi: 10.1002/(SICI)1097-0282(1998)47:6<451::AID-BIP4>3.0.CO;2-F contributor: fullname: Oren – volume: 1788 start-page: 1790 year: 2009 ident: 10.1016/j.bbamem.2015.09.010_bb0285 article-title: Fungicidal effect of antimicrobial peptide arenicin-1 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamem.2009.06.008 contributor: fullname: Park – volume: 278 start-page: 28553 year: 2003 ident: 10.1016/j.bbamem.2015.09.010_bb0270 article-title: Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M300680200 contributor: fullname: Li – volume: 50 start-page: 102 year: 1997 ident: 10.1016/j.bbamem.2015.09.010_bb0220 article-title: Solid-phase peptide synthesis at elevated temperatures: a search for and optimized synthesis condition of unsulfated cholecystokinin-12 publication-title: J. Pept. Res. doi: 10.1111/j.1399-3011.1997.tb01175.x contributor: fullname: Varanda – volume: 30 start-page: 131 year: 2009 ident: 10.1016/j.bbamem.2015.09.010_bb0085 article-title: AMPedup immunity: how antimicrobial peptides have multiple roles in immune defense publication-title: Trends Immunol. doi: 10.1016/j.it.2008.12.003 contributor: fullname: Lai – volume: 282 start-page: 18831 year: 2007 ident: 10.1016/j.bbamem.2015.09.010_bb0295 article-title: Energy depletion protects Candida albicans against antimicrobial peptides by rigidifying its cell membrane publication-title: J. Biol. Chem. doi: 10.1074/jbc.M610555200 contributor: fullname: Veerman – volume: 278 start-page: 3942 year: 2011 ident: 10.1016/j.bbamem.2015.09.010_bb0100 article-title: Antimicrobial peptides important in innate immunity publication-title: FEBS J. doi: 10.1111/j.1742-4658.2011.08302.x contributor: fullname: Cederlund – volume: 1768 start-page: 2667 year: 2007 ident: 10.1016/j.bbamem.2015.09.010_bb0245 article-title: Antimicrobial activity of histidine-rich peptides is dependent on acidic conditions publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamem.2007.06.020 contributor: fullname: Kacprzy – volume: 275 start-page: G514 year: 1998 ident: 10.1016/j.bbamem.2015.09.010_bb0300 article-title: Adsorptive-mediated endocytosis of a basic peptide in enterocyte-like caco-2 cells publication-title: Am. J. Phys. contributor: fullname: Sai – volume: 279 start-page: 14784 year: 2004 ident: 10.1016/j.bbamem.2015.09.010_bb0210 article-title: Systematic peptide engineering and structural characterization to search for the shortest antimicrobial peptide analogue of gaegurin 5 publication-title: J. Biolumin. Chemilumin. contributor: fullname: Won – volume: 13 start-page: 6859 year: 2008 ident: 10.1016/j.bbamem.2015.09.010_bb0110 article-title: Hemocidins in a functional and structural context of juman antimicrobial peptides publication-title: Front. Biosci. doi: 10.2741/3194 contributor: fullname: Mak – volume: 40 start-page: 78 year: 2003 ident: 10.1016/j.bbamem.2015.09.010_bb0165 article-title: Antibacterial hemoglobin fragments from the midgut of the soft tick, Ornithodoros moubata (Acari: Argasidae) publication-title: J. Med. Entomol. doi: 10.1603/0022-2585-40.1.78 contributor: fullname: Nakajima – volume: 27 start-page: 1794 year: 2006 ident: 10.1016/j.bbamem.2015.09.010_bb0180 article-title: A hemoglobin fragment found in cervicovaginal fluid from women in labor potentiates the action of agents that promote contraction of smooth muscle cells publication-title: Peptides doi: 10.1016/j.peptides.2006.03.015 contributor: fullname: Brown – volume: 6 start-page: 468 year: 2006 ident: 10.1016/j.bbamem.2015.09.010_bb0090 article-title: Antibacterial peptides for the therapeutic use: obstacles and realistic outlook publication-title: Curr. Opin. Pharmacol. doi: 10.1016/j.coph.2006.04.006 contributor: fullname: Marr – volume: 34 start-page: 896 year: 2012 ident: 10.1016/j.bbamem.2015.09.010_bb0115 article-title: Antimicrobial properties of hemoglobin publication-title: Immunopharmacol. Immunotoxicol. doi: 10.3109/08923973.2012.692380 contributor: fullname: Sheshadri – volume: 491 start-page: 159 year: 2001 ident: 10.1016/j.bbamem.2015.09.010_bb0130 article-title: Antibacterial activity of a pepsin-derived bovine hemoglobin fragment publication-title: FEBS Lett. doi: 10.1016/S0014-5793(01)02171-8 contributor: fullname: Froidevaux – volume: 27 start-page: 2082 year: 2006 ident: 10.1016/j.bbamem.2015.09.010_bb0140 article-title: Isolation and characterization of four antibacterial peptides from bovine hemoglobin publication-title: Peptides doi: 10.1016/j.peptides.2006.03.033 contributor: fullname: Nedjar-Arroume – volume: 14 start-page: 15739 year: 2012 ident: 10.1016/j.bbamem.2015.09.010_bb0310 article-title: The antimicrobial peptide aurein 1.2 disrupts model membranes via the carpet mechanism publication-title: Phys. Chem. Chem. Phys. doi: 10.1039/c2cp43099a contributor: fullname: Fernandez – volume: 20 start-page: 133 year: 2007 ident: 10.1016/j.bbamem.2015.09.010_bb0010 article-title: Epidemiology of invasive candidiasis a persistent public health problem publication-title: Clin. Microbiol. Rev. doi: 10.1128/CMR.00029-06 contributor: fullname: Pfaller – volume: 81 start-page: 571 year: 2009 ident: 10.1016/j.bbamem.2015.09.010_bb0020 article-title: Surveillance programs for detection and characterization of emergent pathogens and antimicrobial resistance publication-title: Annals Braz. Acad. Sci doi: 10.1590/S0001-37652009000300020 contributor: fullname: Colombo – volume: 77 start-page: 197 year: 2000 ident: 10.1016/j.bbamem.2015.09.010_bb0105 article-title: Antimicrobial peptides derived from heme-containing proteins: hemocidins publication-title: Antonie Van Leeuwenhoek doi: 10.1023/A:1002081605784 contributor: fullname: Mak – volume: 26 start-page: 713 year: 2005 ident: 10.1016/j.bbamem.2015.09.010_bb0135 article-title: New antibacterial peptide derived from bovine hemoglobin publication-title: Peptides doi: 10.1016/j.peptides.2004.12.008 contributor: fullname: Daoud – volume: 36 start-page: 1021 year: 2013 ident: 10.1016/j.bbamem.2015.09.010_bb0200 article-title: Hemocidins derived from hemoglobin: structures, properties and perspectives publication-title: Quim. Nova doi: 10.1590/S0100-40422013000700017 contributor: fullname: Carvalho – volume: 1798 start-page: 228 year: 2010 ident: 10.1016/j.bbamem.2015.09.010_bb0075 article-title: Can antimicrobial peptides scavenge around a cell in less than a Second? publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamem.2009.08.018 contributor: fullname: Chekmenev – volume: 49 start-page: 143 year: 2011 ident: 10.1016/j.bbamem.2015.09.010_bb0155 article-title: Obtaining antimicrobial peptides by controlled peptic hydrolysis of bovine hemoglobin publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2011.04.004 contributor: fullname: Adje – volume: 45 start-page: 6079 year: 2004 ident: 10.1016/j.bbamem.2015.09.010_bb0235 article-title: An efficient method for the solid-phase synthesis of fluorescently labelled peptides publication-title: Tetrahedron Lett. doi: 10.1016/j.tetlet.2004.05.081 contributor: fullname: Fernández-Carneado – volume: 32 start-page: 1463 year: 2011 ident: 10.1016/j.bbamem.2015.09.010_bb0150 article-title: RYH: a minimal peptidic sequence obtained from α-chain hemoglobin exhibiting an antimicrobial activity publication-title: Peptides doi: 10.1016/j.peptides.2011.05.021 contributor: fullname: Catiau – volume: 44 start-page: 2816 year: 2006 ident: 10.1016/j.bbamem.2015.09.010_bb0015 article-title: Epidemiology of candidemia in Brazil: a nation sentinel surveillance of candidemia in eleven medical centers publication-title: J. Clin. Microbiol. doi: 10.1128/JCM.00773-06 contributor: fullname: Colombo – volume: 88 start-page: 413 year: 2007 ident: 10.1016/j.bbamem.2015.09.010_bb0215 article-title: Truncation of amidated fragment 33–61 of bovine alpha-hemoglobin: effects on the structure and anticandidal activity publication-title: Biopolymers doi: 10.1002/bip.20688 contributor: fullname: Machado – volume: 3 start-page: 63 year: 2010 ident: 10.1016/j.bbamem.2015.09.010_bb0195 article-title: Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides publication-title: Parasit. Vectors doi: 10.1186/1756-3305-3-63 contributor: fullname: Cruz – volume: 65 start-page: 2898 year: 1997 ident: 10.1016/j.bbamem.2015.09.010_bb0280 article-title: Effects of pH and salinity on the antimicrobial properties of clavanins publication-title: Infect. Immun. doi: 10.1128/IAI.65.7.2898-2903.1997 contributor: fullname: Lee – volume: 131 start-page: 421 year: 1967 ident: 10.1016/j.bbamem.2015.09.010_bb0290 article-title: Azide inhibition of mitochondrial eletron transport. I. The aerobic steady state of succinate oxidation publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2728(67)90002-3 contributor: fullname: Wilson – volume: 611 start-page: 165 year: 2009 ident: 10.1016/j.bbamem.2015.09.010_bb0230 article-title: Further studies on peptide synthesis on high temperature. Peptides for Youth publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-0-387-73657-0_75 contributor: fullname: Loffredo – volume: 27 start-page: 767 year: 2011 ident: 10.1016/j.bbamem.2015.09.010_bb0190 article-title: Isolation and characterization of an antimicrobial peptide from bovine hemoglobin α-subunit publication-title: World J. Microbiol. Biotechnol. doi: 10.1007/s11274-010-0514-4 contributor: fullname: Hu – ident: 10.1016/j.bbamem.2015.09.010_bb0255 – volume: 54 start-page: 1110 year: 2012 ident: 10.1016/j.bbamem.2015.09.010_bb0025 article-title: Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials publication-title: Clin. Infect. Dis. doi: 10.1093/cid/cis021 contributor: fullname: Andes – volume: 108 start-page: 69 year: 1971 ident: 10.1016/j.bbamem.2015.09.010_bb0070 article-title: Nystatin-resistance mutants of yeast: alterations in sterol content publication-title: J. Bacteriol. doi: 10.1128/JB.108.1.69-73.1971 contributor: fullname: Woods – volume: 29 start-page: 978 year: 2008 ident: 10.1016/j.bbamem.2015.09.010_bb0005 article-title: Secular trends in candidiasis related hospitalization in the United States publication-title: Infect. Control Hosp. Epidemiol. doi: 10.1086/591033 contributor: fullname: Zilberberg – volume: 56 start-page: 5194 year: 2012 ident: 10.1016/j.bbamem.2015.09.010_bb0275 article-title: Intracellular toxicity of proline-rich antimicrobial peptides shuttled into mammalian cells by the cell-penetrating peptide penetratin publication-title: Antimicrob. Agents Chemother. doi: 10.1128/AAC.00585-12 contributor: fullname: Hansen – volume: 15 start-page: 51 year: 2009 ident: 10.1016/j.bbamem.2015.09.010_bb0320 article-title: On the physiology and pathophysiology of antimicrobial peptide publication-title: Mol. Med. doi: 10.2119/molmed.2008.00087 contributor: fullname: Pálffy |
SSID | ssj0016425 ssj0025309 |
Score | 2.2455077 |
Snippet | This study expands the knowledge on chemical synthesis and properties of Hb40-61a as well as provides results of the first steps given towards knowing how it... |
SourceID | crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 3140 |
SubjectTerms | Amino Acid Sequence Animals Antifungal Agents - chemistry Antifungal Agents - pharmacology Antimicrobial peptides Candida - drug effects Cattle Erythrocytes - drug effects Fluorescent Dyes - chemistry Fungicidal action Hemocidins Hemoglobin-derived peptides Hemoglobins - chemistry Humans Membrane permeabilization Membrane Potentials - drug effects Microbial Sensitivity Tests Molecular Sequence Data Peptide synthesis at 60 °C Peptides - chemistry Peptides - pharmacology |
Title | Hb40-61a: Novel analogues help expanding the knowledge on chemistry, properties and candidacidal action of this bovine α-hemoglobin-derived peptide |
URI | https://dx.doi.org/10.1016/j.bbamem.2015.09.010 https://www.ncbi.nlm.nih.gov/pubmed/26367061 |
Volume | 1848 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwEB6VVoheEC0_LbSrOXDE1HacTdJbu6LadmEPiMLeIie21UVtErVLBReeoi_Ci_BMeOJk215A4hBZiTRO5JmMR-P5vgF4ramLSKIzlimumZLc-8HUlmwohcmstyBjCJz8YTocn6qTWTxbgVGPhaGyys73B5_eeuvuyV63mnvNfE4YX07sYcRozmUWE-MncXsSiG92uDxJ8PF16GLACXtFR5U7tzVeRaEvLOHRRdyynRKO9q_b05295-gJPO6CRjwI37UBK7bahIehjeSPTXg06ru2PYWbcUGV9kLv47S-tueoq5CeucIze96g_d4EIAv6yA-XGTWsKyz7Wd5gQyn6S-Ja9fIGSxIxuvSXn7BFQmDtkHoZY0EpCYu_fzEvXhO_yLxixtv1tTXYUM2Msc_g9Ojdp9GYdZ0XWKl4umBORjpWQmcudVGhk4Qbx10iRCHpaNdJ66ifeqFkkvkAjjsXSd22Bo-0ViaOnsNqVVd2CzAlutU0Ui7mXsbF2v-WpSu9WzBCxWW0Daxf8LwJBBt5X3n2NQ8KyklBOc9yr6BtSHqt5PcMJfd7wD8kXwQlLt8jh0RfNxQv_3vOV7BOd6G-ZQdWF5ff7K6PUhbFAB68_SkGsHZw-HnynsbjyXhK4-Tjl8mgNdI_4kTqww |
link.rule.ids | 315,786,790,3525,4521,24144,27602,27957,27958,45620,45698,45714,45909 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwEB6VVqhcKtpCWyhlDhxr1XHsTcINVlTbvz210t4sJ7bFopJEZVuV9-BFeJE-E544WeACUg-5JBon8kzGI3u-7wN4Z0hFJDMFKyQ3TAoe8mDuKjYSiS1ciCBrCZx8MR1NruTpTM1WYDxgYaitss_9Mad32bq_c9TP5lE7nxPGlxN7GDGac1Go9AmsSVVwCu2T2cflUUIosKOMASfwFZ1V7v9u8ipL89URID1RHd0pAWn_uT79sfgcP4eNvmrED_HDNmHF1VvwNOpIft-C9fEg27YNPyYltdon5j1Omzt3jaaO-zPf8LO7btHdtxHJgqH0w-WWGjY1VsMoh9jSHv0Nka0Ge4sVmVhThSsM2EEhsPFIYsZY0p6Ew4efLJg3RDAyr5kNgX3nLLbUNGPdC7g6_nQ5nrBeeoFVkucL5kVqlExM4XOflibLuPXcZ0lSCjrb9cJ5ElQvpciKUMFx71NhOm3w1BhpVfoSVuumdruAOfGt5qn0igcbr0z4LytfhbxgE6mqdA_YMOG6jQwbemg9-6KjgzQ5SPNCBwftQTZ4Rf8VKTosAv-x3IlOXL5HjIi_bpS8evSYb2F9cnlxrs9Ppmev4Rk9ic0u-7C6uLl1b0LJsigPupD8BVZ-6Cg |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hb40-61a%3A+Novel+analogues+help+expanding+the+knowledge+on+chemistry%2C+properties+and+candidacidal+action+of+this+bovine+%CE%B1-hemoglobin-derived+peptide&rft.jtitle=Biochimica+et+biophysica+acta.+Biomembranes&rft.au=Carvalho%2C+L.A.C.&rft.au=Remuzgo%2C+C.&rft.au=Perez%2C+K.R.&rft.au=Machini%2C+M.T.&rft.date=2015-12-01&rft.issn=0005-2736&rft.volume=1848&rft.issue=12&rft.spage=3140&rft.epage=3149&rft_id=info:doi/10.1016%2Fj.bbamem.2015.09.010&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_bbamem_2015_09_010 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0005-2736&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0005-2736&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0005-2736&client=summon |