Therapeutic potential of neurotrophic factors in Alzheimer’s Disease

Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is accompanied with the dysregulation of specific neurotrophic factors (NTFs) and their receptors, which plays a critical role in neuronal deg...

Full description

Saved in:
Bibliographic Details
Published inMolecular biology reports Vol. 49; no. 3; pp. 2345 - 2357
Main Authors Nasrolahi, Ava, Javaherforooshzadeh, Fatemeh, Jafarzadeh-Gharehziaaddin, Mohsen, Mahmoudi, Javad, Asl, Khadijeh Dizaji, Shabani, Zahra
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.03.2022
Springer Nature B.V
Subjects
Aged
Alzheimer disease
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Alzheimer's disease
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
brain
Cell death
Cognitive ability
cognitive disorders
Dementia disorders
dopamine
elderly
Glial cells
Growth factors
Histology
Humans
Life Sciences
ligands
molecular biology
Morphology
Nerve Growth Factors - metabolism
Nerve Growth Factors - therapeutic use
Neurodegeneration
Neurodegenerative diseases
neuroglia
Neuronal-glial interactions
neurons
Neurotrophic factors
neurotrophins
Older people
Review
therapeutics
Alzheimer’s disease
GDNF
Neurotrophic factors
NGF
BDNF
Online AccessGet full text

Cover

Abstract Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is accompanied with the dysregulation of specific neurotrophic factors (NTFs) and their receptors, which plays a critical role in neuronal degeneration. NTFs are small proteins with therapeutic potential for human neurodegenerative diseases. These growth factors are categorized into four families: neurotrophins, neurokines, the glial cell line-derived NTF family of ligands, and the newly discovered cerebral dopamine NTF/mesencephalic astrocyte-derived NTF family. NTFs are capable of preventing cell death in degenerative conditions and can increase the neuronal growth and function in these disorders. Nevertheless, the adverse side effects of NTFs delivery and poor diffusion of these factors in the brain restrict the efficacy of NTFs therapy in clinical situations. Materials and methods In this review, we focus on the current advances in the use of NTFs to treat AD and summarize previous experimental and clinical studies for supporting the protective and therapeutic effects of these factors. Conclusion Based on reports, NTFs are considered as new and promising candidates for treating AD and AD-associated cognitive impairment.
AbstractList Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is accompanied with the dysregulation of specific neurotrophic factors (NTFs) and their receptors, which plays a critical role in neuronal degeneration. NTFs are small proteins with therapeutic potential for human neurodegenerative diseases. These growth factors are categorized into four families: neurotrophins, neurokines, the glial cell line-derived NTF family of ligands, and the newly discovered cerebral dopamine NTF/mesencephalic astrocyte-derived NTF family. NTFs are capable of preventing cell death in degenerative conditions and can increase the neuronal growth and function in these disorders. Nevertheless, the adverse side effects of NTFs delivery and poor diffusion of these factors in the brain restrict the efficacy of NTFs therapy in clinical situations. In this review, we focus on the current advances in the use of NTFs to treat AD and summarize previous experimental and clinical studies for supporting the protective and therapeutic effects of these factors. Based on reports, NTFs are considered as new and promising candidates for treating AD and AD-associated cognitive impairment.
IntroductionAlzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is accompanied with the dysregulation of specific neurotrophic factors (NTFs) and their receptors, which plays a critical role in neuronal degeneration. NTFs are small proteins with therapeutic potential for human neurodegenerative diseases. These growth factors are categorized into four families: neurotrophins, neurokines, the glial cell line-derived NTF family of ligands, and the newly discovered cerebral dopamine NTF/mesencephalic astrocyte-derived NTF family. NTFs are capable of preventing cell death in degenerative conditions and can increase the neuronal growth and function in these disorders. Nevertheless, the adverse side effects of NTFs delivery and poor diffusion of these factors in the brain restrict the efficacy of NTFs therapy in clinical situations.Materials and methodsIn this review, we focus on the current advances in the use of NTFs to treat AD and summarize previous experimental and clinical studies for supporting the protective and therapeutic effects of these factors.ConclusionBased on reports, NTFs are considered as new and promising candidates for treating AD and AD-associated cognitive impairment.
Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is accompanied with the dysregulation of specific neurotrophic factors (NTFs) and their receptors, which plays a critical role in neuronal degeneration. NTFs are small proteins with therapeutic potential for human neurodegenerative diseases. These growth factors are categorized into four families: neurotrophins, neurokines, the glial cell line-derived NTF family of ligands, and the newly discovered cerebral dopamine NTF/mesencephalic astrocyte-derived NTF family. NTFs are capable of preventing cell death in degenerative conditions and can increase the neuronal growth and function in these disorders. Nevertheless, the adverse side effects of NTFs delivery and poor diffusion of these factors in the brain restrict the efficacy of NTFs therapy in clinical situations. Materials and methods In this review, we focus on the current advances in the use of NTFs to treat AD and summarize previous experimental and clinical studies for supporting the protective and therapeutic effects of these factors. Conclusion Based on reports, NTFs are considered as new and promising candidates for treating AD and AD-associated cognitive impairment.
INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is accompanied with the dysregulation of specific neurotrophic factors (NTFs) and their receptors, which plays a critical role in neuronal degeneration. NTFs are small proteins with therapeutic potential for human neurodegenerative diseases. These growth factors are categorized into four families: neurotrophins, neurokines, the glial cell line-derived NTF family of ligands, and the newly discovered cerebral dopamine NTF/mesencephalic astrocyte-derived NTF family. NTFs are capable of preventing cell death in degenerative conditions and can increase the neuronal growth and function in these disorders. Nevertheless, the adverse side effects of NTFs delivery and poor diffusion of these factors in the brain restrict the efficacy of NTFs therapy in clinical situations. MATERIALS AND METHODS: In this review, we focus on the current advances in the use of NTFs to treat AD and summarize previous experimental and clinical studies for supporting the protective and therapeutic effects of these factors. CONCLUSION: Based on reports, NTFs are considered as new and promising candidates for treating AD and AD-associated cognitive impairment.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is accompanied with the dysregulation of specific neurotrophic factors (NTFs) and their receptors, which plays a critical role in neuronal degeneration. NTFs are small proteins with therapeutic potential for human neurodegenerative diseases. These growth factors are categorized into four families: neurotrophins, neurokines, the glial cell line-derived NTF family of ligands, and the newly discovered cerebral dopamine NTF/mesencephalic astrocyte-derived NTF family. NTFs are capable of preventing cell death in degenerative conditions and can increase the neuronal growth and function in these disorders. Nevertheless, the adverse side effects of NTFs delivery and poor diffusion of these factors in the brain restrict the efficacy of NTFs therapy in clinical situations.INTRODUCTIONAlzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is accompanied with the dysregulation of specific neurotrophic factors (NTFs) and their receptors, which plays a critical role in neuronal degeneration. NTFs are small proteins with therapeutic potential for human neurodegenerative diseases. These growth factors are categorized into four families: neurotrophins, neurokines, the glial cell line-derived NTF family of ligands, and the newly discovered cerebral dopamine NTF/mesencephalic astrocyte-derived NTF family. NTFs are capable of preventing cell death in degenerative conditions and can increase the neuronal growth and function in these disorders. Nevertheless, the adverse side effects of NTFs delivery and poor diffusion of these factors in the brain restrict the efficacy of NTFs therapy in clinical situations.In this review, we focus on the current advances in the use of NTFs to treat AD and summarize previous experimental and clinical studies for supporting the protective and therapeutic effects of these factors.MATERIALS AND METHODSIn this review, we focus on the current advances in the use of NTFs to treat AD and summarize previous experimental and clinical studies for supporting the protective and therapeutic effects of these factors.Based on reports, NTFs are considered as new and promising candidates for treating AD and AD-associated cognitive impairment.CONCLUSIONBased on reports, NTFs are considered as new and promising candidates for treating AD and AD-associated cognitive impairment.
Author Asl, Khadijeh Dizaji
Nasrolahi, Ava
Jafarzadeh-Gharehziaaddin, Mohsen
Shabani, Zahra
Javaherforooshzadeh, Fatemeh
Mahmoudi, Javad
Author_xml – sequence: 1
  givenname: Ava
  surname: Nasrolahi
  fullname: Nasrolahi, Ava
  organization: Infectious Ophthalmologic Research Center, Imam Khomeini Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Pain Research Center, Imam Khomeini Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences
– sequence: 2
  givenname: Fatemeh
  surname: Javaherforooshzadeh
  fullname: Javaherforooshzadeh, Fatemeh
  organization: Pain Research Center, Imam Khomeini Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences
– sequence: 3
  givenname: Mohsen
  surname: Jafarzadeh-Gharehziaaddin
  fullname: Jafarzadeh-Gharehziaaddin, Mohsen
  organization: Department of Education and Psychology, University of Aveiro
– sequence: 4
  givenname: Javad
  surname: Mahmoudi
  fullname: Mahmoudi, Javad
  organization: Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences
– sequence: 5
  givenname: Khadijeh Dizaji
  surname: Asl
  fullname: Asl, Khadijeh Dizaji
  organization: Department of Anatomical Science, Tabriz University of Medical Sciences
– sequence: 6
  givenname: Zahra
  orcidid: 0000-0003-4995-3024
  surname: Shabani
  fullname: Shabani, Zahra
  email: zh.shabani67@gmail.com
  organization: Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Department of Neuroscience, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34826049$$D View this record in MEDLINE/PubMed
BookMark eNqNkbFuFDEQhi0URC4JL0CBVqJJszBe22u7jEICSJHSJLXlW485R3v2YnsLUvEavB5Pwh6XCClFlGqK-b7RzPxH5CCmiIS8o_CRAshPhVJgrIWOttDrXrX6FVlRIVnLtVQHZAUMaMuVoIfkqJQ7AOBUijfkkHHV9cD1ilzebDDbCecahmZKFWMNdmySbyLOOdWcps3S8XaoKZcmxOZsvN9g2GL-8-t3aT6HgrbgCXnt7Vjw7UM9JreXFzfnX9ur6y_fzs-u2oGDqi0q75xfa-GAaes4Bb22sCtecIodrKnrfO_Aa47ovBXWUe8HPngtBWPsmJzu5045_ZixVLMNZcBxtBHTXEzXc6U47yV9AQocul5LvaAfnqB3ac5xOWShGOVSSBAL9f6BmtdbdGbKYWvzT_P4zAVQe2DIqZSM3gyh2hpSrNmG0VAwu9zMPjez5Gb-5WZ2avdEfZz-rMT2Ulng-B3z_7Wfsf4C55Wqfw
CitedBy_id crossref_primary_10_3390_md20110708
crossref_primary_10_1016_j_neurot_2024_e00350
crossref_primary_10_2174_0118715249264888230920060941
crossref_primary_10_3390_ijms241310751
crossref_primary_10_1002_adfm_202416572
crossref_primary_10_3389_fphar_2024_1373660
crossref_primary_10_1016_j_neurol_2022_09_003
crossref_primary_10_4103_1673_5374_369096
crossref_primary_10_2174_1871527322666230607110617
crossref_primary_10_3390_ijms23094999
crossref_primary_10_1016_j_tifs_2023_104300
crossref_primary_10_1007_s12035_025_04776_x
crossref_primary_10_1111_cns_14560
crossref_primary_10_3390_antiox12051042
crossref_primary_10_3390_cells11203201
crossref_primary_10_3390_jpm12111884
crossref_primary_10_3233_JAD_231010
crossref_primary_10_4236_jbm_2023_111009
Cites_doi 10.1126/science.aan8821
10.1523/ENEURO.0419-17.2018
10.3389/fnagi.2021.714186
10.3389/fcell.2021.667412
10.1002/btm2.10264
10.1016/j.brainres.2018.12.034
10.1016/j.nbd.2016.03.026
10.1523/JNEUROSCI.3687-12.2013
10.1016/j.neurobiolaging.2009.03.011
10.1016/j.bbr.2015.05.002
10.1038/s41598-016-0001-8
10.1159/000017069
10.3727/096368912X638964
10.1016/j.biomaterials.2011.03.072
10.1186/s12929-019-0592-z
10.14336/AD.2015.0825
10.1006/nbdi.2001.0429
10.3390/ijms20020257
10.3390/ijms18030630
10.15562/bmj.v8i2.1460
10.1038/tp.2017.95
10.1001/archneur.57.6.846
10.1016/j.nbd.2016.03.027
10.1001/jamainternmed.2021.4607
10.1001/jamaneurol.2018.0233
10.3390/ijms18030548
10.1007/s11064-015-1535-z
10.1089/hum.2015.065
10.1007/s10072-020-04909-1
10.1515/revneuro-2017-0040
10.1038/mp.2014.123
10.1038/srep28646
10.1006/exnr.2002.7869
10.1159/000438701
10.1159/000450601
10.1111/cns.12312
10.1093/brain/aww200
10.1016/j.neurobiolaging.2012.07.018
10.1016/j.omtm.2018.03.001
10.1007/s11011-018-0303-6
10.1523/JNEUROSCI.4182-09.2010
10.3389/fnmol.2019.00123
10.1097/00001756-199611250-00024
10.1016/j.yexcr.2018.08.007
10.3390/ijms21207777
10.1089/dna.2019.5308
10.1074/jbc.M111.310250
10.1016/j.neuropharm.2014.01.037
10.1089/hum.2019.367
10.1159/000089137
10.1016/S0014-4886(03)00044-X
10.1016/j.ejphar.2008.06.109
10.1038/nm1239
10.3389/fnins.2019.00790
10.3233/JAD-190150
10.1016/j.neulet.2016.09.008
10.1016/S0896-6273(00)80853-3
10.1007/978-1-4939-7571-6_1
10.1080/00207454.2019.1667794
10.1038/jcbfm.2009.75
10.1186/s13195-016-0175-0
10.1186/s12906-017-1775-3
10.1002/(SICI)1097-4598(199908)22:8<983::AID-MUS1>3.0.CO;2-V
10.1002/cne.903600307
10.3233/JAD-131073
10.1016/j.jconrel.2015.03.024
10.3233/JAD-2009-1004
10.1007/BF02257624
10.2174/156720511798192754
10.1093/ijnp/pyw024
10.1038/s41380-019-0404-6
10.1186/2047-9158-1-14
10.1038/srep27358
10.1016/j.neurobiolaging.2019.07.018
10.1016/j.ajpath.2015.03.009
10.1159/000336051
10.1002/jnr.22830
10.1016/S0736-5748(00)00046-0
10.1016/S0165-3806(99)00047-4
10.3233/JAD-141068
10.1017/S1461145710000738
10.1016/j.lfs.2016.10.004
10.1016/j.pbb.2013.03.003
10.2174/1567205010666131120100743
10.1134/S0026893316040105
10.1016/j.jalz.2013.09.004
10.1007/978-3-030-74046-7_11
10.1016/j.exger.2017.03.007
10.1016/0166-4328(93)90141-C
10.1016/j.neurobiolaging.2016.08.020
10.1523/JNEUROSCI.12-11-04391.1992
10.1016/j.psyneuen.2018.09.038
10.1016/j.neulet.2008.05.107
10.1038/nn1855
10.1016/j.jfma.2015.04.001
10.1007/s00406-007-0764-9
10.3390/ijms22168814
10.1136/bmjopen-2016-015746
10.1007/s00401-005-1038-0
10.3389/fnins.2019.00062
ContentType Journal Article
Copyright The Author(s), under exclusive licence to Springer Nature B.V. 2021
2021. The Author(s), under exclusive licence to Springer Nature B.V.
The Author(s), under exclusive licence to Springer Nature B.V. 2021.
Copyright_xml – notice: The Author(s), under exclusive licence to Springer Nature B.V. 2021
– notice: 2021. The Author(s), under exclusive licence to Springer Nature B.V.
– notice: The Author(s), under exclusive licence to Springer Nature B.V. 2021.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7TK
7TM
7X7
7XB
88A
88E
88I
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
RC3
7X8
7S9
L.6
DOI 10.1007/s11033-021-06968-9
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Neurosciences Abstracts
Nucleic Acids Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials - QC
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Science Database
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
Genetics Abstracts
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Central Student
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList MEDLINE
ProQuest Central Student

AGRICOLA
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
Biology
EISSN 1573-4978
EndPage 2357
ExternalDocumentID 34826049
10_1007_s11033_021_06968_9
Genre Journal Article
Review
GroupedDBID ---
-4W
-56
-5G
-BR
-EM
-Y2
-~C
.86
.GJ
.VR
06C
06D
0R~
0VY
123
1SB
203
28-
29M
29~
2J2
2JN
2JY
2KG
2KM
2LR
2P1
2VQ
2~H
30V
3SX
3V.
4.4
406
408
409
40E
53G
5QI
5RE
5VS
67N
67Z
6NX
78A
7X7
88A
88E
88I
8AO
8FE
8FH
8FI
8FJ
8TC
8UJ
95-
95.
95~
96X
AAAVM
AABHQ
AACDK
AAHBH
AAHNG
AAIAL
AAJBT
AAJKR
AANXM
AANZL
AARHV
AARTL
AASML
AATNV
AATVU
AAUYE
AAWCG
AAYIU
AAYQN
AAYTO
AAYZH
ABBBX
ABBXA
ABDZT
ABECU
ABFTV
ABHLI
ABHQN
ABJNI
ABJOX
ABKCH
ABKTR
ABMNI
ABMQK
ABNWP
ABPLI
ABQBU
ABQSL
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABULA
ABUWG
ABWNU
ABXPI
ACAOD
ACBXY
ACDTI
ACGFS
ACGOD
ACHSB
ACHXU
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPIV
ACPRK
ACZOJ
ADBBV
ADHHG
ADHIR
ADIMF
ADINQ
ADKNI
ADKPE
ADRFC
ADTPH
ADURQ
ADYFF
ADYPR
ADZKW
AEBTG
AEFIE
AEFQL
AEGAL
AEGNC
AEJHL
AEJRE
AEKMD
AEMSY
AENEX
AEOHA
AEPYU
AESKC
AETLH
AEVLU
AEXYK
AFBBN
AFEXP
AFGCZ
AFKRA
AFLOW
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGGDS
AGJBK
AGMZJ
AGQEE
AGQMX
AGRTI
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHMBA
AHSBF
AHYZX
AIAKS
AIGIU
AIIXL
AILAN
AITGF
AJBLW
AJRNO
AJZVZ
AKMHD
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMXSW
AMYLF
AMYQR
AOCGG
ARMRJ
ASPBG
AVWKF
AXYYD
AZFZN
AZQEC
B-.
BA0
BBNVY
BBWZM
BDATZ
BENPR
BGNMA
BHPHI
BPHCQ
BSONS
BVXVI
CAG
CCPQU
COF
CS3
CSCUP
DDRTE
DL5
DNIVK
DPUIP
DU5
DWQXO
EBD
EBLON
EBS
EIOEI
EJD
EMOBN
EN4
EPAXT
ESBYG
F5P
FEDTE
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FWDCC
FYUFA
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GNUQQ
GNWQR
GQ6
GQ7
GQ8
GXS
H13
HCIFZ
HF~
HG5
HG6
HMCUK
HMJXF
HQYDN
HRMNR
HVGLF
HZ~
I09
IHE
IJ-
IKXTQ
ITM
IWAJR
IXC
IZIGR
IZQ
I~X
I~Z
J-C
J0Z
JBSCW
JCJTX
JZLTJ
KDC
KOV
KOW
KPH
LAK
LK8
LLZTM
M0L
M1P
M2P
M4Y
M7P
MA-
N2Q
NB0
NDZJH
NPVJJ
NQJWS
NU0
O9-
O93
O9G
O9I
O9J
OAM
OVD
P19
PF0
PQQKQ
PROAC
PSQYO
PT4
PT5
Q2X
QOK
QOR
QOS
R4E
R89
R9I
RHV
RIG
RNI
RNS
ROL
RPX
RRX
RSV
RZC
RZE
RZK
S16
S1Z
S26
S27
S28
S3A
S3B
SAP
SBL
SBY
SCLPG
SDH
SDM
SHX
SISQX
SJYHP
SNE
SNPRN
SNX
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
SV3
SZN
T13
T16
TEORI
TSG
TSK
TSV
TUC
TUS
U2A
U9L
UG4
UKHRP
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W23
W48
WH7
WJK
WK6
WK8
YLTOR
Z45
Z7U
Z7V
Z7W
Z7Y
Z82
Z83
Z87
Z8O
Z8P
Z8Q
Z8S
Z8V
Z8W
Z91
ZMTXR
ZOVNA
ZXP
~A9
~EX
~KM
AAPKM
AAYXX
ABAKF
ABBRH
ABDBE
ABFSG
ACSTC
ADHKG
AEZWR
AFDZB
AFHIU
AFOHR
AGQPQ
AHPBZ
AHWEU
AIXLP
ATHPR
AYFIA
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7TK
7TM
7XB
8FD
8FK
ABRTQ
FR3
K9.
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
Q9U
RC3
7X8
7S9
L.6
ID FETCH-LOGICAL-c408t-e8fddfb95d039ad4109ba04109f541e20b1d2f6d0f94eedfa5ad1ffc4cf975333
IEDL.DBID U2A
ISSN 0301-4851
1573-4978
IngestDate Thu Jul 10 22:58:47 EDT 2025
Fri Jul 11 01:24:27 EDT 2025
Wed Aug 13 04:46:26 EDT 2025
Thu Apr 03 06:56:34 EDT 2025
Tue Jul 01 03:18:19 EDT 2025
Thu Apr 24 23:13:32 EDT 2025
Fri Feb 21 02:47:07 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords Alzheimer’s disease
GDNF
Neurotrophic factors
NGF
BDNF
Language English
License 2021. The Author(s), under exclusive licence to Springer Nature B.V.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c408t-e8fddfb95d039ad4109ba04109f541e20b1d2f6d0f94eedfa5ad1ffc4cf975333
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0003-4995-3024
PMID 34826049
PQID 2631475705
PQPubID 54080
PageCount 13
ParticipantIDs proquest_miscellaneous_2648844671
proquest_miscellaneous_2604026979
proquest_journals_2631475705
pubmed_primary_34826049
crossref_citationtrail_10_1007_s11033_021_06968_9
crossref_primary_10_1007_s11033_021_06968_9
springer_journals_10_1007_s11033_021_06968_9
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20220300
2022-03-00
2022-Mar
20220301
PublicationDateYYYYMMDD 2022-03-01
PublicationDate_xml – month: 3
  year: 2022
  text: 20220300
PublicationDecade 2020
PublicationPlace Dordrecht
PublicationPlace_xml – name: Dordrecht
– name: Netherlands
PublicationSubtitle An International Journal on Molecular and Cellular Biology
PublicationTitle Molecular biology reports
PublicationTitleAbbrev Mol Biol Rep
PublicationTitleAlternate Mol Biol Rep
PublicationYear 2022
Publisher Springer Netherlands
Springer Nature B.V
Publisher_xml – name: Springer Netherlands
– name: Springer Nature B.V
References Zheng (CR67) 2018; 33
Shabani (CR21) 2021
Falcicchia (CR65) 2018; 9
Leyhe (CR68) 2009; 16
Sidorova, Saarma (CR90) 2016; 50
Scharfman (CR61) 2002; 174
Eriksdotter-Jönhagen (CR33) 2012; 33
Gao (CR70) 2018; 22
Jia (CR80) 2019; 100
Wang (CR87) 2013; 107
Mitsumoto, Tsuzaka (CR83) 1999; 22
Narisawa-Saito (CR75) 1996; 7
Yan (CR78) 2016; 166
Petukhova (CR103) 2019; 69
Bhardwaj, Deshmukh (CR24) 2018; 7
Alvarez (CR69) 2016; 19
Franzmeier (CR46) 2021; 26
Colucci-D’Amato, Speranza, Volpicelli (CR45) 2020; 21
Leyhe (CR66) 2008; 258
Mitra (CR93) 2021
Nasrolahi (CR7) 2019; 18
Garcia (CR84) 2010; 30
Bartus, Johnson (CR12) 2017; 97
Revilla (CR99) 2014; 81
Eyjolfsdottir (CR19) 2016; 8
Henriques, Pitzer, Schneider (CR110) 2010; 4
Rafii (CR39) 2018; 75
Yang (CR44) 2017; 7
Mitra (CR31) 2021
Rafii (CR38) 2015; 2015
Marksteiner (CR96) 2011; 32
Borba (CR49) 2016; 6
Coelho (CR52) 2014; 39
Budni (CR91) 2015; 6
Li, Shi, Zhao (CR4) 2018
Blasko (CR50) 2006; 21
Bi (CR86) 2018; 11
Ferreira (CR41) 2015; 43
Ng (CR48) 2019; 20
Kemppainen (CR108) 2015; 291
Airavaara (CR94) 2011; 286
Ledda (CR97) 2007; 10
Xia (CR54) 2017; 9
Seiger (CR35) 1993; 57
Lim (CR56) 2015; 20
Straten (CR102) 2011; 8
Nasrolahi (CR107) 2018; 29
Castle (CR40) 2020; 31
Revilla (CR100) 2014; 20
Wu (CR63) 2016; 6
Minichiello (CR59) 1999; 24
Choi (CR71) 2018
Naegelin (CR14) 2018
Lee (CR17) 2012; 21
Ahn (CR9) 2016; 6
Hashimoto (CR81) 1999; 115
Huang, Chao, Hu (CR1) 2020; 27
Qu (CR82) 2008; 594
Baydyuk (CR74) 2013; 33
Wang (CR88) 2015; 40
Han (CR18) 2011; 32
Yan (CR73) 2021; 15
Hiramatsu (CR105) 2015; 185
Lee (CR30) 2018; 18
Durany (CR76) 2000; 18
Olson (CR34) 1992; 4
Krashia, Nobili, D’Amelio (CR92) 2019; 12
Baazaoui (CR85) 2016
Dunn, Stein, Cavazzoni (CR6) 2021; 181
Shekari, Fahnestock (CR29) 2019; 84
Sopova (CR8) 2014; 11
Knusel (CR60) 1992; 12
Ribeiro (CR72) 2021; 22
Rosa (CR57) 2016; 48
Klein (CR53) 2011; 14
McBride (CR111) 2003; 181
Zhu (CR112) 2009; 29
Domanskyi, Saarma, Airavaara (CR10) 2015; 26
Hu (CR58) 2019; 1710
Weissmiller, Wu (CR25) 2012; 1
Zhou (CR109) 2016; 633
Keefe, Sheikh, Smith (CR27) 2017; 18
Lauterborn (CR47) 1995; 360
Qing (CR104) 2020; 39
Bature (CR3) 2017; 7
Lim (CR55) 2016; 139
Silakarma, Sudewi (CR43) 2019; 8
Chakraborty, Diwan (CR2) 2020; 1
Staudt (CR79) 2016; 62
Rafii (CR32) 2014; 10
Skaper (CR22) 2018; 1727
Kumar (CR5) 2016; 115
Jönhagen (CR15) 1998; 9
Hoozemans (CR106) 2005; 110
Lauzon (CR16) 2015; 206
Xie (CR51) 2019; 130
Wu (CR64) 2016; 6
Sharif, Noroozian, Hashemian (CR95) 2021; 42
Hock (CR77) 2000; 57
Houlton (CR11) 2019; 13
Tuszynski (CR37) 2005; 11
Wang (CR89) 2017; 92
Zhou (CR26) 2021
Petukhova (CR101) 2019; 69
Iwasaki (CR20) 2012; 90
Bartus (CR13) 2013; 34
Sánchez-Sánchez, Arévalo (CR23) 2017; 18
Eriksdotter (CR42) 2018; 371
Cuello, Pentz, Hall (CR28) 2019; 13
Xuan (CR62) 2008; 440
Bartus, Johnson (CR36) 2017; 97
Ghribi (CR98) 2001; 8
A Chakraborty (6968_CR2) 2020; 1
W Hu (6968_CR58) 2019; 1710
Y Hashimoto (6968_CR81) 1999; 115
B Dunn (6968_CR6) 2021; 181
AC Cuello (6968_CR28) 2019; 13
D Ferreira (6968_CR41) 2015; 43
A Henriques (6968_CR110) 2010; 4
C-C Wu (6968_CR63) 2016; 6
S Kemppainen (6968_CR108) 2015; 291
RT Bartus (6968_CR36) 2017; 97
E Rosa (6968_CR57) 2016; 48
T Leyhe (6968_CR66) 2008; 258
SM Ahn (6968_CR9) 2016; 6
M-A Lauzon (6968_CR16) 2015; 206
HA Lee (6968_CR30) 2018; 18
N Durany (6968_CR76) 2000; 18
S Mitra (6968_CR93) 2021
YY Lim (6968_CR55) 2016; 139
J Qing (6968_CR104) 2020; 39
à Seiger (6968_CR35) 1993; 57
C-C Wu (6968_CR64) 2016; 6
MJ Castle (6968_CR40) 2020; 31
M Airavaara (6968_CR94) 2011; 286
EO Petukhova (6968_CR103) 2019; 69
L Minichiello (6968_CR59) 1999; 24
D Wang (6968_CR88) 2015; 40
B Yang (6968_CR44) 2017; 7
KM Keefe (6968_CR27) 2017; 18
SH Choi (6968_CR71) 2018
Y Iwasaki (6968_CR20) 2012; 90
XA Alvarez (6968_CR69) 2016; 19
Z Yan (6968_CR73) 2021; 15
M Eriksdotter-Jönhagen (6968_CR33) 2012; 33
K Sopova (6968_CR8) 2014; 11
A Domanskyi (6968_CR10) 2015; 26
N Franzmeier (6968_CR46) 2021; 26
Y Naegelin (6968_CR14) 2018
L-T Zhou (6968_CR26) 2021
A Kumar (6968_CR5) 2016; 115
O Ghribi (6968_CR98) 2001; 8
S Revilla (6968_CR99) 2014; 81
B Xie (6968_CR51) 2019; 130
R Bhardwaj (6968_CR24) 2018; 7
D-Y Xia (6968_CR54) 2017; 9
W Zhu (6968_CR112) 2009; 29
C Falcicchia (6968_CR65) 2018; 9
F Bature (6968_CR3) 2017; 7
A Nasrolahi (6968_CR107) 2018; 29
AM Weissmiller (6968_CR25) 2012; 1
D Ribeiro (6968_CR72) 2021; 22
MS Rafii (6968_CR32) 2014; 10
FGdM Coelho (6968_CR52) 2014; 39
RT Bartus (6968_CR12) 2017; 97
EO Petukhova (6968_CR101) 2019; 69
P Krashia (6968_CR92) 2019; 12
T Li (6968_CR4) 2018
H Eyjolfsdottir (6968_CR19) 2016; 8
YY Lim (6968_CR56) 2015; 20
HE Scharfman (6968_CR61) 2002; 174
S Mitra (6968_CR31) 2021
L Olson (6968_CR34) 1992; 4
HJ Lee (6968_CR17) 2012; 21
Z Shabani (6968_CR21) 2021
L-K Huang (6968_CR1) 2020; 27
M-l Gao (6968_CR70) 2018; 22
G Bi (6968_CR86) 2018; 11
S Revilla (6968_CR100) 2014; 20
H Zheng (6968_CR67) 2018; 33
C Jia (6968_CR80) 2019; 100
M Sharif (6968_CR95) 2021; 42
RT Bartus (6968_CR13) 2013; 34
F Ledda (6968_CR97) 2007; 10
G Straten (6968_CR102) 2011; 8
JC Lauterborn (6968_CR47) 1995; 360
D Wang (6968_CR89) 2017; 92
I Blasko (6968_CR50) 2006; 21
Q Han (6968_CR18) 2011; 32
SD Skaper (6968_CR22) 2018; 1727
D Wang (6968_CR87) 2013; 107
MS Rafii (6968_CR39) 2018; 75
N Baazaoui (6968_CR85) 2016
H Mitsumoto (6968_CR83) 1999; 22
HY Qu (6968_CR82) 2008; 594
J Marksteiner (6968_CR96) 2011; 32
P Garcia (6968_CR84) 2010; 30
TKS Ng (6968_CR48) 2019; 20
AB Klein (6968_CR53) 2011; 14
A Nasrolahi (6968_CR7) 2019; 18
M Baydyuk (6968_CR74) 2013; 33
A Xuan (6968_CR62) 2008; 440
T Leyhe (6968_CR68) 2009; 16
ME Jönhagen (6968_CR15) 1998; 9
L Colucci-D’Amato (6968_CR45) 2020; 21
N Hiramatsu (6968_CR105) 2015; 185
EM Borba (6968_CR49) 2016; 6
W Zhou (6968_CR109) 2016; 633
JL McBride (6968_CR111) 2003; 181
C Hock (6968_CR77) 2000; 57
J Houlton (6968_CR11) 2019; 13
MD Staudt (6968_CR79) 2016; 62
A Shekari (6968_CR29) 2019; 84
J Budni (6968_CR91) 2015; 6
M Rafii (6968_CR38) 2015; 2015
Y-h Yan (6968_CR78) 2016; 166
Y Sidorova (6968_CR90) 2016; 50
MH Tuszynski (6968_CR37) 2005; 11
J Sánchez-Sánchez (6968_CR23) 2017; 18
J Hoozemans (6968_CR106) 2005; 110
D Silakarma (6968_CR43) 2019; 8
M Narisawa-Saito (6968_CR75) 1996; 7
M Eriksdotter (6968_CR42) 2018; 371
B Knusel (6968_CR60) 1992; 12
References_xml – volume: 12
  start-page: 4391
  issue: 11
  year: 1992
  end-page: 4402
  ident: CR60
  article-title: Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat brain
  publication-title: J Neurosci
– volume: 39
  start-page: 401
  issue: 2
  year: 2014
  end-page: 408
  ident: CR52
  article-title: Acute aerobic exercise increases brain-derived neurotrophic factor levels in elderly with Alzheimer’s disease
  publication-title: J Alzheimers Dis
– year: 2018
  ident: CR71
  article-title: Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model
  publication-title: Science
  doi: 10.1126/science.aan8821
– volume: 92
  start-page: 42
  year: 2017
  end-page: 45
  ident: CR89
  article-title: Treatment effects of Cardiotrophin-1 (CT-1) on streptozotocin-induced memory deficits in mice
  publication-title: Exp Gerontol
– volume: 21
  start-page: 9
  issue: 1
  year: 2006
  end-page: 15
  ident: CR50
  article-title: Measurement of thirteen biological markers in CSF of patients with Alzheimer’s disease and other dementias
  publication-title: Dement Geriatr Cogn Disord
– volume: 18
  start-page: 630
  issue: 3
  year: 2017
  ident: CR23
  article-title: A review on ubiquitination of neurotrophin receptors: facts and perspectives
  publication-title: Int J Mol Sci
– volume: 1710
  start-page: 61
  year: 2019
  end-page: 73
  ident: CR58
  article-title: Brain-derived neurotrophic factor modified human umbilical cord mesenchymal stem cells-derived cholinergic-like neurons improve spatial learning and memory ability in Alzheimer’s disease rats
  publication-title: Brain Res
– volume: 206
  start-page: 187
  year: 2015
  end-page: 205
  ident: CR16
  article-title: Nanoparticle-mediated growth factor delivery systems: a new way to treat Alzheimer’s disease
  publication-title: J Controlled Release
– volume: 440
  start-page: 331
  issue: 3
  year: 2008
  end-page: 335
  ident: CR62
  article-title: BDNF improves the effects of neural stem cells on the rat model of Alzheimer’s disease with unilateral lesion of fimbria-fornix
  publication-title: Neurosci Lett
– year: 2016
  ident: CR85
  publication-title: Effect of CNTF derived peptide, P021 on cognition and pathology in 3xTG-AD mouse model of Alzheimer’s disease
– volume: 8
  start-page: 764
  issue: 5
  year: 2001
  end-page: 773
  ident: CR98
  article-title: GDNF protects against aluminum-induced apoptosis in rabbits by upregulating Bcl-2 and Bcl-XL and inhibiting mitochondrial Bax translocation
  publication-title: Neurobiol Dis
– volume: 31
  start-page: 415
  issue: 7–8
  year: 2020
  end-page: 422
  ident: CR40
  article-title: Postmortem analysis in a clinical trial of AAV2-NGF gene therapy for Alzheimer’s disease identifies a need for improved vector delivery
  publication-title: Hum Gene Ther
– volume: 14
  start-page: 347
  issue: 3
  year: 2011
  end-page: 353
  ident: CR53
  article-title: Blood BDNF concentrations reflect brain-tissue BDNF levels across species
  publication-title: Int J Neuropsychopharmacol
– volume: 29
  start-page: 1528
  issue: 9
  year: 2009
  end-page: 1537
  ident: CR112
  article-title: Postischemic IGF-1 gene transfer promotes neurovascular regeneration after experimental stroke
  publication-title: J Cereb Blood Flow Metab
– volume: 20
  start-page: 1322
  issue: 11
  year: 2015
  ident: CR56
  article-title: APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer’s disease
  publication-title: Mol Psychiatry
– volume: 633
  start-page: 40
  year: 2016
  end-page: 46
  ident: CR109
  article-title: Cerebral dopamine neurotrophic factor alleviates Aβ25-35-induced endoplasmic reticulum stress and early synaptotoxicity in rat hippocampal cells
  publication-title: Neurosci Lett
– volume: 50
  start-page: 521
  issue: 4
  year: 2016
  end-page: 531
  ident: CR90
  article-title: Glial cell line-derived neurotrophic factor family ligands and their therapeutic potential
  publication-title: Mol Biol
– volume: 181
  start-page: 213
  issue: 2
  year: 2003
  end-page: 223
  ident: CR111
  article-title: Structural and functional neuroprotection in a rat model of Huntington’s disease by viral gene transfer of GDNF
  publication-title: Exp Neurol
– volume: 33
  start-page: 1961
  issue: 6
  year: 2018
  end-page: 1974
  ident: CR67
  article-title: Donepezil improves the cognitive impairment in a tree shrew model of Alzheimer’s disease induced by amyloid-β 1–40 via activating the BDNF/TrkB signal pathway
  publication-title: Metab Brain Dis
– volume: 40
  start-page: 843
  issue: 4
  year: 2015
  end-page: 853
  ident: CR88
  article-title: Cardiotrophin-1 (CT-1) improves high fat diet-induced cognitive deficits in mice
  publication-title: Neurochem Res
– volume: 9
  start-page: 246
  issue: 5
  year: 1998
  end-page: 257
  ident: CR15
  article-title: Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer’s disease
  publication-title: Dement Geriatr Cogn Disord
– volume: 6
  start-page: 331
  issue: 5
  year: 2015
  ident: CR91
  article-title: The involvement of BDNF, NGF and GDNF in aging and Alzheimer’s disease
  publication-title: Aging Dis
– volume: 166
  start-page: 131
  year: 2016
  end-page: 138
  ident: CR78
  article-title: Neurotrophin-3 promotes proliferation and cholinergic neuronal differentiation of bone marrow-derived neural stem cells via notch signaling pathway
  publication-title: Life Sci
– volume: 12
  start-page: 123
  year: 2019
  ident: CR92
  article-title: Unifying hypothesis of dopamine neuron loss in neurodegenerative diseases: focusing on Alzheimer’s disease
  publication-title: Front Mol Neurosci
– volume: 16
  start-page: 649
  issue: 3
  year: 2009
  end-page: 656
  ident: CR68
  article-title: Increase of BDNF serum concentration in lithium treated patients with early Alzheimer’s disease
  publication-title: J Alzheimers Dis
– year: 2018
  ident: CR14
  article-title: Measuring and validating the levels of brain-derived neurotrophic factor in human serum
  publication-title: Eneuro
  doi: 10.1523/ENEURO.0419-17.2018
– volume: 7
  start-page: 2925
  issue: 18
  year: 1996
  end-page: 2928
  ident: CR75
  article-title: Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer’s disease
  publication-title: NeuroReport
– volume: 107
  start-page: 48
  year: 2013
  end-page: 57
  ident: CR87
  article-title: Cardiotrophin-1 (CTF1) ameliorates glucose-uptake defects and improves memory and learning deficits in a transgenic mouse model of Alzheimer’s disease
  publication-title: Pharmacol Biochem Behav
– volume: 130
  start-page: 218
  issue: 3
  year: 2019
  end-page: 230
  ident: CR51
  article-title: Evaluation of the diagnostic value of peripheral BDNF levels for Alzheimer’s disease and mild cognitive impairment: results of a meta-analysis
  publication-title: Int J Neurosci
– volume: 8
  start-page: 853
  issue: 8
  year: 2011
  end-page: 859
  ident: CR102
  article-title: Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer’s disease
  publication-title: Curr Alzheimer Res
– volume: 291
  start-page: 1
  year: 2015
  end-page: 11
  ident: CR108
  article-title: Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer’s disease as well as in wild-type mice
  publication-title: Behav Brain Res
– volume: 6
  start-page: 559
  issue: 3
  year: 2016
  end-page: 567
  ident: CR49
  article-title: Brain-derived neurotrophic factor serum levels and hippocampal volume in mild cognitive impairment and dementia due to Alzheimer disease
  publication-title: Dementia and geriatric cognitive disorders extra
– volume: 6
  start-page: 28646
  year: 2016
  ident: CR9
  article-title: Electroacupuncture ameliorates memory impairments by enhancing oligodendrocyte regeneration in a mouse model of prolonged cerebral hypoperfusion
  publication-title: Sci Rep
– volume: 27
  start-page: 1
  issue: 1
  year: 2020
  end-page: 13
  ident: CR1
  article-title: Clinical trials of new drugs for Alzheimer disease
  publication-title: J Biomed Sci
– volume: 10
  start-page: 293
  issue: 3
  year: 2007
  ident: CR97
  article-title: GDNF and GFRα1 promote formation of neuronal synapses by ligand-induced cell adhesion
  publication-title: Nat Neurosci
– volume: 174
  start-page: 201
  issue: 2
  year: 2002
  end-page: 214
  ident: CR61
  article-title: Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor
  publication-title: Exp Neurol
– volume: 18
  start-page: 139
  year: 2019
  ident: CR7
  article-title: Effect of cerebral dopamine neurotrophic factor on endogenous neural progenitor cell migration in a rat model of Parkinson’s disease
  publication-title: EXCLI J
– volume: 8
  start-page: 1
  year: 2016
  end-page: 111
  ident: CR19
  article-title: Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer’s disease patients: application of a second-generation encapsulated cell biodelivery device
  publication-title: Alzheimer’s Res Ther
– volume: 11
  start-page: 551
  issue: 5
  year: 2005
  ident: CR37
  article-title: A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
  publication-title: Nat Med
– year: 2018
  ident: CR4
  publication-title: Phosphorylation of microtubule-associated protein tau by mitogen-activated protein kinase in Alzheimer’s disease
– volume: 7
  start-page: 53
  issue: 4
  year: 2018
  end-page: 62
  ident: CR24
  article-title: Neurotrophic factors and Parkinson’s disease
  publication-title: Clin Invest
– volume: 115
  start-page: 3
  issue: 1
  year: 2016
  end-page: 10
  ident: CR5
  article-title: Current and novel therapeutic molecules and targets in Alzheimer’s disease
  publication-title: J Formos Med Assoc
– volume: 84
  start-page: 131
  year: 2019
  end-page: 140
  ident: CR29
  article-title: Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons
  publication-title: Neurobiol Aging
– volume: 62
  start-page: 371
  issue: 3
  year: 2016
  end-page: 380
  ident: CR79
  article-title: Advances in neurotrophic factor and cell-based therapies for Parkinson’s disease: a mini-review
  publication-title: Gerontology
– volume: 20
  start-page: 257
  issue: 2
  year: 2019
  ident: CR48
  article-title: Decreased serum brain-derived neurotrophic factor (BDNF) levels in patients with Alzheimer’s disease (AD): a systematic review and meta-analysis
  publication-title: Int J Mol Sci
– volume: 2015
  start-page: 274
  year: 2015
  end-page: 275
  ident: CR38
  article-title: A Phase II trial of AAV2-NGF in mild to moderate Alzheimer’s disease
  publication-title: J Prev Alzheimers Dis
– volume: 39
  start-page: 1064
  issue: 6
  year: 2020
  end-page: 1071
  ident: CR104
  article-title: Hippo/YAP Pathway Plays a Critical Role in Effect of GDNF Against Aβ-Induced Inflammation in Microglial Cells
  publication-title: DNA Cell Biol
– volume: 32
  start-page: 5077
  issue: 22
  year: 2011
  end-page: 5085
  ident: CR18
  article-title: The promotion of cerebral ischemia recovery in rats by laminin-binding BDNF
  publication-title: Biomaterials
– volume: 24
  start-page: 401
  issue: 2
  year: 1999
  end-page: 414
  ident: CR59
  article-title: Essential role for TrkB receptors in hippocampus-mediated learning
  publication-title: Neuron
– volume: 57
  start-page: 846
  issue: 6
  year: 2000
  end-page: 851
  ident: CR77
  article-title: Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas
  publication-title: Arch Neurol
– volume: 34
  start-page: 35
  issue: 1
  year: 2013
  end-page: 61
  ident: CR13
  article-title: Advancing neurotrophic factors as treatments for age-related neurodegenerative diseases: developing and demonstrating “clinical proof-of-concept” for AAV-neurturin (CERE-120) in Parkinson’s disease
  publication-title: Neurobiol Aging
– volume: 594
  start-page: 93
  issue: 1–3
  year: 2008
  end-page: 100
  ident: CR82
  article-title: Transducible P11-CNTF rescues the learning and memory impairments induced by amyloid-beta peptide in mice
  publication-title: Eur J Pharmacol
– volume: 6
  start-page: 1
  issue: 1
  year: 2016
  end-page: 16
  ident: CR64
  article-title: Gain of BDNF function in engrafted neural stem cells promotes the therapeutic potential for Alzheimer’s disease
  publication-title: Sci Rep
– volume: 8
  start-page: 427
  issue: 2
  year: 2019
  end-page: 434
  ident: CR43
  article-title: The role of brain-derived neurotrophic factor (BDNF) in cognitive functions
  publication-title: Bali Medical Journal
– volume: 33
  start-page: 18
  issue: 1
  year: 2012
  end-page: 28
  ident: CR33
  article-title: Encapsulated cell biodelivery of nerve growth factor to the basal forebrain in patients with Alzheimer’s disease
  publication-title: Dement Geriatr Cogn Disord
– volume: 43
  start-page: 1059
  issue: 3
  year: 2015
  end-page: 1072
  ident: CR41
  article-title: Brain changes in Alzheimer’s disease patients with implanted encapsulated cells releasing nerve growth factor
  publication-title: J Alzheimers Dis
– volume: 33
  start-page: 3363
  issue: 8
  year: 2013
  end-page: 3369
  ident: CR74
  article-title: Midbrain-derived neurotrophins support survival of immature striatal projection neurons
  publication-title: J Neurosci
– volume: 48
  start-page: 135
  year: 2016
  end-page: 142
  ident: CR57
  article-title: Tau downregulates BDNF expression in animal and cellular models of Alzheimer’s disease
  publication-title: Neurobiol Aging
– volume: 57
  start-page: 255
  issue: 2
  year: 1993
  end-page: 261
  ident: CR35
  article-title: Intracranial infusion of purified nerve growth factor to an Alzheimer patient: the first attempt of a possible future treatment strategy
  publication-title: Behav Brain Res
– volume: 42
  start-page: 2865
  issue: 7
  year: 2021
  end-page: 2872
  ident: CR95
  article-title: Do serum GDNF levels correlate with severity of Alzheimer’s disease?
  publication-title: Neurol Sci
– volume: 69
  start-page: 443
  issue: 2
  year: 2019
  end-page: 453
  ident: CR103
  article-title: Effects of transplanted umbilical cord blood mononuclear cells overexpressing GDNF on spatial memory and hippocampal synaptic proteins in a mouse model of Alzheimer’s disease
  publication-title: J Alzheimers Dis
– volume: 181
  start-page: 1276
  issue: 10
  year: 2021
  end-page: 1278
  ident: CR6
  article-title: Approval of dducanumab for Alzheimer disease—the FDA’s perspective
  publication-title: JAMA Internal Med
– volume: 75
  start-page: 834
  issue: 7
  year: 2018
  end-page: 841
  ident: CR39
  article-title: Adeno-associated viral vector (serotype 2)–nerve growth factor for patients with Alzheimer disease: a randomized clinical trial
  publication-title: JAMA Neurol
– volume: 19
  start-page: pyw024
  issue: 6
  year: 2016
  ident: CR69
  article-title: Synergistic increase of serum BDNF in Alzheimer patients treated with cerebrolysin and donepezil: association with cognitive improvement in ApoE4 cases
  publication-title: Int J Neuropsychopharmacol
– volume: 90
  start-page: 981
  issue: 5
  year: 2012
  end-page: 989
  ident: CR20
  article-title: Sendai virus vector-mediated brain‐derived neurotrophic factor expression ameliorates memory deficits and synaptic degeneration in a transgenic mouse model of Alzheimer’s disease
  publication-title: J Neurosci Res
– volume: 18
  start-page: 548
  issue: 3
  year: 2017
  ident: CR27
  article-title: Targeting neurotrophins to specific populations of neurons: NGF, BDNF, and NT-3 and their relevance for treatment of spinal cord injury
  publication-title: Int J Mol Sci
– volume: 9
  start-page: 211
  year: 2018
  end-page: 224
  ident: CR65
  article-title: Seizure-suppressant and neuroprotective effects of encapsulated BDNF-producing cells in a rat model of temporal lobe epilepsy
  publication-title: Mol Ther-Methods Clin Dev
– volume: 22
  start-page: 8814
  issue: 16
  year: 2021
  ident: CR72
  article-title: The impact of physical exercise on the circulating levels of BDNF and NT 4/5: a review
  publication-title: Int J Mol Sci
– volume: 115
  start-page: 25
  issue: 1
  year: 1999
  end-page: 32
  ident: CR81
  article-title: Synergistic effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on cultured basal forebrain cholinergic neurons from postnatal 2-week-old rats
  publication-title: Dev Brain Res
– volume: 139
  start-page: 2766
  issue: 10
  year: 2016
  end-page: 2777
  ident: CR55
  article-title: BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer’s disease
  publication-title: Brain
– volume: 22
  start-page: 1419
  issue: 9
  year: 2018
  end-page: 1424
  ident: CR70
  article-title: Effects of braln-derived neurotrophic factor-modified human amniotic membrane-derived mesenchymal stem cell transplantation on learning and memory abilities of alzheimer’s disease rats
  publication-title: Chin J Tissue Eng Res
– volume: 18
  start-page: 125
  issue: 1
  year: 2018
  ident: CR30
  article-title: Asparagus cochinchinensis stimulates release of nerve growth factor and abrogates oxidative stress in the Tg2576 model for Alzheimer’s disease
  publication-title: BMC Complement Altern Med
– volume: 371
  start-page: 175
  issue: 1
  year: 2018
  end-page: 184
  ident: CR42
  article-title: Cerebrospinal fluid from Alzheimer patients affects cell-mediated nerve growth factor production and cell survival in vitro
  publication-title: Exp Cell Res
– volume: 7
  start-page: e1128
  issue: 5
  year: 2017
  end-page: e1128
  ident: CR44
  article-title: Altered expression of BDNF, BDNF pro-peptide and their precursor proBDNF in brain and liver tissues from psychiatric disorders: rethinking the brain–liver axis
  publication-title: Transl Psychiatry
– volume: 11
  start-page: 1855
  issue: 4
  year: 2018
  ident: CR86
  article-title: Therapeutic effect of transmembrane TAT-tCNTF via Erk and Akt activation using in vitro and in vivo models of Alzheimer’s disease
  publication-title: Int J Clin Exp Pathol
– volume: 20
  start-page: 961
  issue: 11
  year: 2014
  end-page: 972
  ident: CR100
  article-title: Lenti-GDNF gene therapy protects against Alzheimer’s disease‐like neuropathology in 3xTg‐AD mice and MC65 cells
  publication-title: CNS Neurosci Ther
– volume: 11
  start-page: 27
  issue: 1
  year: 2014
  end-page: 39
  ident: CR8
  article-title: Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer’s disease: from pathophysiology to novel treatment strategies
  publication-title: Curr Alzheimer Res
– volume: 7
  start-page: e015746
  issue: 8
  year: 2017
  ident: CR3
  article-title: Signs and symptoms preceding the diagnosis of Alzheimer’s disease: a systematic scoping review of literature from 1937 to 2016
  publication-title: BMJ Open
– volume: 97
  start-page: 169
  year: 2017
  end-page: 178
  ident: CR36
  article-title: Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 2: Where do we stand and where must we go next?
  publication-title: Neurobiol Dis
– volume: 4
  start-page: 32
  year: 2010
  ident: CR110
  article-title: Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand?
  publication-title: Front NeuroSci
– volume: 6
  start-page: 27358
  year: 2016
  ident: CR63
  article-title: Gain of BDNF function in engrafted neural stem cells promotes the therapeutic potential for Alzheimer’s disease
  publication-title: Sci Rep
– volume: 26
  start-page: 550
  issue: 8
  year: 2015
  end-page: 559
  ident: CR10
  article-title: Prospects of neurotrophic factors for Parkinson’s disease: comparison of protein and gene therapy
  publication-title: Hum Gene Ther
– volume: 100
  start-page: 96
  year: 2019
  end-page: 105
  ident: CR80
  article-title: Ciliary neurotrophic factor is a key sex-specific regulator of depressive-like behavior in mice
  publication-title: Psychoneuroendocrinology
– year: 2021
  ident: CR93
  article-title: Increased endogenous GDNF in mice protects against age-related decline in neuronal cholinergic markers
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2021.714186
– volume: 69
  start-page: 443
  issue: 2
  year: 2019
  end-page: 453
  ident: CR101
  article-title: Effects of transplanted umbilical cord blood mononuclear cells overexpressing GDNF on spatial memory and hippocampal synaptic proteins in a mouse model of Alzheimer’s disease
  publication-title: J Alzheimer’s Dis
– volume: 286
  start-page: 45093
  issue: 52
  year: 2011
  end-page: 45102
  ident: CR94
  article-title: Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease
  publication-title: J Biol Chem
– volume: 32
  start-page: 539
  issue: 3
  year: 2011
  end-page: 540
  ident: CR96
  article-title: Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer’s disease
  publication-title: Neurobiol Aging
– volume: 30
  start-page: 7516
  issue: 22
  year: 2010
  end-page: 7527
  ident: CR84
  article-title: Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer’s disease
  publication-title: J Neurosci
– volume: 22
  start-page: 983
  issue: 8
  year: 1999
  end-page: 999
  ident: CR83
  article-title: Neurotrophic factors and neuromuscular disease: I. General comments, the neurotrophin family, and neuropoietic cytokines
  publication-title: Muscle Nerve: Off J Am Assoc Electrodiagn Med
– volume: 1727
  start-page: 1
  year: 2018
  end-page: 17
  ident: CR22
  article-title: Neurotrophic factors: an overview
  publication-title: Neurotrop Factors
– volume: 9
  start-page: 65
  year: 2017
  ident: CR54
  article-title: PGC-1α or FNDC5 is involved in modulating the effects of Aβ1– 42 oligomers on suppressing the expression of BDNF, a beneficial factor for inhibiting neuronal apoptosis, Aβ deposition and cognitive decline of APP/PS1 Tg mice
  publication-title: Front Aging Neurosci
– start-page: 167
  year: 2021
  end-page: 191
  ident: CR31
  article-title: A review of techniques for biodelivery of nerve growth factor (NGF) to the brain in relation to Alzheimer’s disease
  publication-title: Recent advances in NGF and related molecules
– volume: 81
  start-page: 55
  year: 2014
  end-page: 63
  ident: CR99
  article-title: Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain
  publication-title: Neuropharmacology
– volume: 29
  start-page: 475
  issue: 5
  year: 2018
  end-page: 489
  ident: CR107
  article-title: Neurotrophic factors hold promise for the future of Parkinson’s disease treatment: is there a light at the end of the tunnel?
  publication-title: Rev Neurosci
– volume: 18
  start-page: 807
  issue: 8
  year: 2000
  end-page: 813
  ident: CR76
  article-title: Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer’s disease brains
  publication-title: Int J Dev Neurosci
– volume: 258
  start-page: 124
  issue: 2
  year: 2008
  end-page: 128
  ident: CR66
  article-title: Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer’s disease
  publication-title: Eur Arch Psychiatry Clin NeuroSci
– volume: 110
  start-page: 165
  issue: 2
  year: 2005
  end-page: 172
  ident: CR106
  article-title: The unfolded protein response is activated in Alzheimer’s disease
  publication-title: Acta Neuropathol
– volume: 21
  start-page: 2487
  issue: 11
  year: 2012
  end-page: 2496
  ident: CR17
  article-title: Human neural stem cells genetically modified to express human nerve growth factor (NGF) gene restore cognition in the mouse with ibotenic acid-induced cognitive dysfunction
  publication-title: Cell Transplant
– volume: 15
  start-page: 18
  year: 2021
  ident: CR73
  article-title: Neurotrophin-3 promotes the neuronal differentiation of BMSCs and improves cognitive function in a rat model of Alzheimer’s disease
  publication-title: Front Cell Neurosci
– volume: 1
  start-page: 115
  issue: 4
  year: 2020
  end-page: 122
  ident: CR2
  article-title: Alzheimer and it’s possible therapy: a review
  publication-title: J Exp Neurol
– volume: 21
  start-page: 7777
  issue: 20
  year: 2020
  ident: CR45
  article-title: Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer
  publication-title: Int J Mol Sci
– volume: 4
  start-page: 79
  issue: 1
  year: 1992
  end-page: 95
  ident: CR34
  article-title: Nerve growth factor affects 11 C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (case report)
  publication-title: Journal of Neural Transmission-Parkinson’s Disease and Dementia Section
– volume: 1
  start-page: 1
  issue: 1
  year: 2012
  end-page: 9
  ident: CR25
  article-title: Current advances in using neurotrophic factors to treat neurodegenerative disorders
  publication-title: Translational neurodegeneration
– year: 2021
  ident: CR26
  article-title: Elevated levels of miR-144-3p induce cholinergic degeneration by impairing the maturation of NGF in Alzheimer’s disease
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2021.667412
– volume: 10
  start-page: 571
  issue: 5
  year: 2014
  end-page: 581
  ident: CR32
  article-title: A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer’s disease
  publication-title: Alzheimer’s Dement
– year: 2021
  ident: CR21
  article-title: Transplantation of bioengineered Reelin-loaded PLGA/PEG micelles can accelerate neural tissue regeneration in photothrombotic stroke model of mouse
  publication-title: Bioeng Transl Med
  doi: 10.1002/btm2.10264
– volume: 360
  start-page: 454
  issue: 3
  year: 1995
  end-page: 462
  ident: CR47
  article-title: NGF mRNA is expressed by GABAergic but not cholinergic neurons in rat basal forebrain
  publication-title: Journal of Comparative Neurology
– volume: 185
  start-page: 1800
  issue: 7
  year: 2015
  end-page: 1808
  ident: CR105
  article-title: Multiple mechanisms of unfolded protein response–induced cell death
  publication-title: Am J Pathol
– volume: 97
  start-page: 156
  year: 2017
  end-page: 168
  ident: CR12
  article-title: Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 1: where have we been and what have we learned?
  publication-title: Neurobiol Dis
– volume: 13
  start-page: 62
  year: 2019
  ident: CR28
  article-title: The brain NGF metabolic pathway in health and in Alzheimer’s pathology
  publication-title: Front NeuroSci
– volume: 13
  start-page: 790
  year: 2019
  ident: CR11
  article-title: Therapeutic potential of neurotrophins for repair after brain injury: a helping hand from biomaterials
  publication-title: Front NeuroSci
– volume: 26
  start-page: 614
  issue: 2
  year: 2021
  end-page: 628
  ident: CR46
  article-title: The BDNF Val66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease
  publication-title: Mol Psychiatry
– volume: 1
  start-page: 115
  issue: 4
  year: 2020
  ident: 6968_CR2
  publication-title: J Exp Neurol
– volume: 1710
  start-page: 61
  year: 2019
  ident: 6968_CR58
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2018.12.034
– volume: 22
  start-page: 1419
  issue: 9
  year: 2018
  ident: 6968_CR70
  publication-title: Chin J Tissue Eng Res
– volume-title: Effect of CNTF derived peptide, P021 on cognition and pathology in 3xTG-AD mouse model of Alzheimer’s disease
  year: 2016
  ident: 6968_CR85
– volume: 97
  start-page: 169
  year: 2017
  ident: 6968_CR36
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2016.03.026
– volume: 33
  start-page: 3363
  issue: 8
  year: 2013
  ident: 6968_CR74
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3687-12.2013
– volume: 32
  start-page: 539
  issue: 3
  year: 2011
  ident: 6968_CR96
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2009.03.011
– volume: 291
  start-page: 1
  year: 2015
  ident: 6968_CR108
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2015.05.002
– volume: 6
  start-page: 1
  issue: 1
  year: 2016
  ident: 6968_CR64
  publication-title: Sci Rep
  doi: 10.1038/s41598-016-0001-8
– volume: 9
  start-page: 246
  issue: 5
  year: 1998
  ident: 6968_CR15
  publication-title: Dement Geriatr Cogn Disord
  doi: 10.1159/000017069
– volume: 21
  start-page: 2487
  issue: 11
  year: 2012
  ident: 6968_CR17
  publication-title: Cell Transplant
  doi: 10.3727/096368912X638964
– volume: 32
  start-page: 5077
  issue: 22
  year: 2011
  ident: 6968_CR18
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2011.03.072
– volume: 27
  start-page: 1
  issue: 1
  year: 2020
  ident: 6968_CR1
  publication-title: J Biomed Sci
  doi: 10.1186/s12929-019-0592-z
– volume: 6
  start-page: 331
  issue: 5
  year: 2015
  ident: 6968_CR91
  publication-title: Aging Dis
  doi: 10.14336/AD.2015.0825
– volume: 8
  start-page: 764
  issue: 5
  year: 2001
  ident: 6968_CR98
  publication-title: Neurobiol Dis
  doi: 10.1006/nbdi.2001.0429
– volume: 20
  start-page: 257
  issue: 2
  year: 2019
  ident: 6968_CR48
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms20020257
– volume: 18
  start-page: 630
  issue: 3
  year: 2017
  ident: 6968_CR23
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms18030630
– volume: 8
  start-page: 427
  issue: 2
  year: 2019
  ident: 6968_CR43
  publication-title: Bali Medical Journal
  doi: 10.15562/bmj.v8i2.1460
– volume: 7
  start-page: e1128
  issue: 5
  year: 2017
  ident: 6968_CR44
  publication-title: Transl Psychiatry
  doi: 10.1038/tp.2017.95
– volume: 2015
  start-page: 274
  year: 2015
  ident: 6968_CR38
  publication-title: J Prev Alzheimers Dis
– volume: 57
  start-page: 846
  issue: 6
  year: 2000
  ident: 6968_CR77
  publication-title: Arch Neurol
  doi: 10.1001/archneur.57.6.846
– volume: 97
  start-page: 156
  year: 2017
  ident: 6968_CR12
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2016.03.027
– volume: 181
  start-page: 1276
  issue: 10
  year: 2021
  ident: 6968_CR6
  publication-title: JAMA Internal Med
  doi: 10.1001/jamainternmed.2021.4607
– volume: 75
  start-page: 834
  issue: 7
  year: 2018
  ident: 6968_CR39
  publication-title: JAMA Neurol
  doi: 10.1001/jamaneurol.2018.0233
– volume: 18
  start-page: 548
  issue: 3
  year: 2017
  ident: 6968_CR27
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms18030548
– volume: 40
  start-page: 843
  issue: 4
  year: 2015
  ident: 6968_CR88
  publication-title: Neurochem Res
  doi: 10.1007/s11064-015-1535-z
– volume: 26
  start-page: 550
  issue: 8
  year: 2015
  ident: 6968_CR10
  publication-title: Hum Gene Ther
  doi: 10.1089/hum.2015.065
– year: 2021
  ident: 6968_CR26
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2021.667412
– volume: 42
  start-page: 2865
  issue: 7
  year: 2021
  ident: 6968_CR95
  publication-title: Neurol Sci
  doi: 10.1007/s10072-020-04909-1
– volume: 29
  start-page: 475
  issue: 5
  year: 2018
  ident: 6968_CR107
  publication-title: Rev Neurosci
  doi: 10.1515/revneuro-2017-0040
– volume: 20
  start-page: 1322
  issue: 11
  year: 2015
  ident: 6968_CR56
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2014.123
– volume: 6
  start-page: 28646
  year: 2016
  ident: 6968_CR9
  publication-title: Sci Rep
  doi: 10.1038/srep28646
– year: 2018
  ident: 6968_CR14
  publication-title: Eneuro
  doi: 10.1523/ENEURO.0419-17.2018
– volume: 174
  start-page: 201
  issue: 2
  year: 2002
  ident: 6968_CR61
  publication-title: Exp Neurol
  doi: 10.1006/exnr.2002.7869
– volume: 62
  start-page: 371
  issue: 3
  year: 2016
  ident: 6968_CR79
  publication-title: Gerontology
  doi: 10.1159/000438701
– volume: 6
  start-page: 559
  issue: 3
  year: 2016
  ident: 6968_CR49
  publication-title: Dementia and geriatric cognitive disorders extra
  doi: 10.1159/000450601
– volume: 20
  start-page: 961
  issue: 11
  year: 2014
  ident: 6968_CR100
  publication-title: CNS Neurosci Ther
  doi: 10.1111/cns.12312
– volume: 15
  start-page: 18
  year: 2021
  ident: 6968_CR73
  publication-title: Front Cell Neurosci
– volume: 139
  start-page: 2766
  issue: 10
  year: 2016
  ident: 6968_CR55
  publication-title: Brain
  doi: 10.1093/brain/aww200
– volume: 34
  start-page: 35
  issue: 1
  year: 2013
  ident: 6968_CR13
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2012.07.018
– volume: 9
  start-page: 211
  year: 2018
  ident: 6968_CR65
  publication-title: Mol Ther-Methods Clin Dev
  doi: 10.1016/j.omtm.2018.03.001
– volume: 33
  start-page: 1961
  issue: 6
  year: 2018
  ident: 6968_CR67
  publication-title: Metab Brain Dis
  doi: 10.1007/s11011-018-0303-6
– volume: 30
  start-page: 7516
  issue: 22
  year: 2010
  ident: 6968_CR84
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4182-09.2010
– volume: 12
  start-page: 123
  year: 2019
  ident: 6968_CR92
  publication-title: Front Mol Neurosci
  doi: 10.3389/fnmol.2019.00123
– volume: 7
  start-page: 2925
  issue: 18
  year: 1996
  ident: 6968_CR75
  publication-title: NeuroReport
  doi: 10.1097/00001756-199611250-00024
– volume: 371
  start-page: 175
  issue: 1
  year: 2018
  ident: 6968_CR42
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2018.08.007
– volume: 21
  start-page: 7777
  issue: 20
  year: 2020
  ident: 6968_CR45
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21207777
– volume: 39
  start-page: 1064
  issue: 6
  year: 2020
  ident: 6968_CR104
  publication-title: DNA Cell Biol
  doi: 10.1089/dna.2019.5308
– volume: 11
  start-page: 1855
  issue: 4
  year: 2018
  ident: 6968_CR86
  publication-title: Int J Clin Exp Pathol
– volume: 286
  start-page: 45093
  issue: 52
  year: 2011
  ident: 6968_CR94
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.310250
– volume: 81
  start-page: 55
  year: 2014
  ident: 6968_CR99
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2014.01.037
– volume: 18
  start-page: 139
  year: 2019
  ident: 6968_CR7
  publication-title: EXCLI J
– volume: 31
  start-page: 415
  issue: 7–8
  year: 2020
  ident: 6968_CR40
  publication-title: Hum Gene Ther
  doi: 10.1089/hum.2019.367
– volume: 21
  start-page: 9
  issue: 1
  year: 2006
  ident: 6968_CR50
  publication-title: Dement Geriatr Cogn Disord
  doi: 10.1159/000089137
– volume: 181
  start-page: 213
  issue: 2
  year: 2003
  ident: 6968_CR111
  publication-title: Exp Neurol
  doi: 10.1016/S0014-4886(03)00044-X
– volume: 594
  start-page: 93
  issue: 1–3
  year: 2008
  ident: 6968_CR82
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2008.06.109
– volume: 11
  start-page: 551
  issue: 5
  year: 2005
  ident: 6968_CR37
  publication-title: Nat Med
  doi: 10.1038/nm1239
– volume: 13
  start-page: 790
  year: 2019
  ident: 6968_CR11
  publication-title: Front NeuroSci
  doi: 10.3389/fnins.2019.00790
– volume: 69
  start-page: 443
  issue: 2
  year: 2019
  ident: 6968_CR101
  publication-title: J Alzheimer’s Dis
  doi: 10.3233/JAD-190150
– volume: 633
  start-page: 40
  year: 2016
  ident: 6968_CR109
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2016.09.008
– volume: 24
  start-page: 401
  issue: 2
  year: 1999
  ident: 6968_CR59
  publication-title: Neuron
  doi: 10.1016/S0896-6273(00)80853-3
– volume: 1727
  start-page: 1
  year: 2018
  ident: 6968_CR22
  publication-title: Neurotrop Factors
  doi: 10.1007/978-1-4939-7571-6_1
– volume: 130
  start-page: 218
  issue: 3
  year: 2019
  ident: 6968_CR51
  publication-title: Int J Neurosci
  doi: 10.1080/00207454.2019.1667794
– volume: 29
  start-page: 1528
  issue: 9
  year: 2009
  ident: 6968_CR112
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/jcbfm.2009.75
– volume: 8
  start-page: 1
  year: 2016
  ident: 6968_CR19
  publication-title: Alzheimer’s Res Ther
  doi: 10.1186/s13195-016-0175-0
– volume: 18
  start-page: 125
  issue: 1
  year: 2018
  ident: 6968_CR30
  publication-title: BMC Complement Altern Med
  doi: 10.1186/s12906-017-1775-3
– volume: 22
  start-page: 983
  issue: 8
  year: 1999
  ident: 6968_CR83
  publication-title: Muscle Nerve: Off J Am Assoc Electrodiagn Med
  doi: 10.1002/(SICI)1097-4598(199908)22:8<983::AID-MUS1>3.0.CO;2-V
– volume: 360
  start-page: 454
  issue: 3
  year: 1995
  ident: 6968_CR47
  publication-title: Journal of Comparative Neurology
  doi: 10.1002/cne.903600307
– volume: 39
  start-page: 401
  issue: 2
  year: 2014
  ident: 6968_CR52
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-131073
– volume: 206
  start-page: 187
  year: 2015
  ident: 6968_CR16
  publication-title: J Controlled Release
  doi: 10.1016/j.jconrel.2015.03.024
– volume: 16
  start-page: 649
  issue: 3
  year: 2009
  ident: 6968_CR68
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-2009-1004
– volume: 4
  start-page: 79
  issue: 1
  year: 1992
  ident: 6968_CR34
  publication-title: Journal of Neural Transmission-Parkinson’s Disease and Dementia Section
  doi: 10.1007/BF02257624
– volume: 8
  start-page: 853
  issue: 8
  year: 2011
  ident: 6968_CR102
  publication-title: Curr Alzheimer Res
  doi: 10.2174/156720511798192754
– volume: 19
  start-page: pyw024
  issue: 6
  year: 2016
  ident: 6968_CR69
  publication-title: Int J Neuropsychopharmacol
  doi: 10.1093/ijnp/pyw024
– volume: 7
  start-page: 53
  issue: 4
  year: 2018
  ident: 6968_CR24
  publication-title: Clin Invest
– volume: 26
  start-page: 614
  issue: 2
  year: 2021
  ident: 6968_CR46
  publication-title: Mol Psychiatry
  doi: 10.1038/s41380-019-0404-6
– year: 2021
  ident: 6968_CR21
  publication-title: Bioeng Transl Med
  doi: 10.1002/btm2.10264
– volume: 9
  start-page: 65
  year: 2017
  ident: 6968_CR54
  publication-title: Front Aging Neurosci
– volume: 1
  start-page: 1
  issue: 1
  year: 2012
  ident: 6968_CR25
  publication-title: Translational neurodegeneration
  doi: 10.1186/2047-9158-1-14
– volume: 6
  start-page: 27358
  year: 2016
  ident: 6968_CR63
  publication-title: Sci Rep
  doi: 10.1038/srep27358
– volume: 84
  start-page: 131
  year: 2019
  ident: 6968_CR29
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2019.07.018
– volume: 185
  start-page: 1800
  issue: 7
  year: 2015
  ident: 6968_CR105
  publication-title: Am J Pathol
  doi: 10.1016/j.ajpath.2015.03.009
– volume: 33
  start-page: 18
  issue: 1
  year: 2012
  ident: 6968_CR33
  publication-title: Dement Geriatr Cogn Disord
  doi: 10.1159/000336051
– volume: 90
  start-page: 981
  issue: 5
  year: 2012
  ident: 6968_CR20
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.22830
– volume: 4
  start-page: 32
  year: 2010
  ident: 6968_CR110
  publication-title: Front NeuroSci
– volume: 18
  start-page: 807
  issue: 8
  year: 2000
  ident: 6968_CR76
  publication-title: Int J Dev Neurosci
  doi: 10.1016/S0736-5748(00)00046-0
– volume: 115
  start-page: 25
  issue: 1
  year: 1999
  ident: 6968_CR81
  publication-title: Dev Brain Res
  doi: 10.1016/S0165-3806(99)00047-4
– volume: 43
  start-page: 1059
  issue: 3
  year: 2015
  ident: 6968_CR41
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-141068
– volume: 14
  start-page: 347
  issue: 3
  year: 2011
  ident: 6968_CR53
  publication-title: Int J Neuropsychopharmacol
  doi: 10.1017/S1461145710000738
– volume: 166
  start-page: 131
  year: 2016
  ident: 6968_CR78
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2016.10.004
– volume: 107
  start-page: 48
  year: 2013
  ident: 6968_CR87
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/j.pbb.2013.03.003
– volume: 11
  start-page: 27
  issue: 1
  year: 2014
  ident: 6968_CR8
  publication-title: Curr Alzheimer Res
  doi: 10.2174/1567205010666131120100743
– volume: 50
  start-page: 521
  issue: 4
  year: 2016
  ident: 6968_CR90
  publication-title: Mol Biol
  doi: 10.1134/S0026893316040105
– year: 2018
  ident: 6968_CR71
  publication-title: Science
  doi: 10.1126/science.aan8821
– volume: 10
  start-page: 571
  issue: 5
  year: 2014
  ident: 6968_CR32
  publication-title: Alzheimer’s Dement
  doi: 10.1016/j.jalz.2013.09.004
– start-page: 167
  volume-title: Recent advances in NGF and related molecules
  year: 2021
  ident: 6968_CR31
  doi: 10.1007/978-3-030-74046-7_11
– volume: 92
  start-page: 42
  year: 2017
  ident: 6968_CR89
  publication-title: Exp Gerontol
  doi: 10.1016/j.exger.2017.03.007
– volume: 57
  start-page: 255
  issue: 2
  year: 1993
  ident: 6968_CR35
  publication-title: Behav Brain Res
  doi: 10.1016/0166-4328(93)90141-C
– volume: 48
  start-page: 135
  year: 2016
  ident: 6968_CR57
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2016.08.020
– volume: 12
  start-page: 4391
  issue: 11
  year: 1992
  ident: 6968_CR60
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.12-11-04391.1992
– volume: 100
  start-page: 96
  year: 2019
  ident: 6968_CR80
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2018.09.038
– volume: 440
  start-page: 331
  issue: 3
  year: 2008
  ident: 6968_CR62
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2008.05.107
– volume: 69
  start-page: 443
  issue: 2
  year: 2019
  ident: 6968_CR103
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-190150
– volume-title: Phosphorylation of microtubule-associated protein tau by mitogen-activated protein kinase in Alzheimer’s disease
  year: 2018
  ident: 6968_CR4
– volume: 10
  start-page: 293
  issue: 3
  year: 2007
  ident: 6968_CR97
  publication-title: Nat Neurosci
  doi: 10.1038/nn1855
– volume: 115
  start-page: 3
  issue: 1
  year: 2016
  ident: 6968_CR5
  publication-title: J Formos Med Assoc
  doi: 10.1016/j.jfma.2015.04.001
– volume: 258
  start-page: 124
  issue: 2
  year: 2008
  ident: 6968_CR66
  publication-title: Eur Arch Psychiatry Clin NeuroSci
  doi: 10.1007/s00406-007-0764-9
– volume: 22
  start-page: 8814
  issue: 16
  year: 2021
  ident: 6968_CR72
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms22168814
– volume: 7
  start-page: e015746
  issue: 8
  year: 2017
  ident: 6968_CR3
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2016-015746
– volume: 110
  start-page: 165
  issue: 2
  year: 2005
  ident: 6968_CR106
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-005-1038-0
– volume: 13
  start-page: 62
  year: 2019
  ident: 6968_CR28
  publication-title: Front NeuroSci
  doi: 10.3389/fnins.2019.00062
– year: 2021
  ident: 6968_CR93
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2021.714186
SSID ssj0004175
Score 2.4124455
SecondaryResourceType review_article
Snippet Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is accompanied with...
IntroductionAlzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is...
INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is...
SourceID proquest
pubmed
crossref
springer
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 2345
SubjectTerms Aged
Alzheimer disease
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Alzheimer's disease
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
brain
Cell death
Cognitive ability
cognitive disorders
Dementia disorders
dopamine
elderly
Glial cells
Growth factors
Histology
Humans
Life Sciences
ligands
molecular biology
Morphology
Nerve Growth Factors - metabolism
Nerve Growth Factors - therapeutic use
Neurodegeneration
Neurodegenerative diseases
neuroglia
Neuronal-glial interactions
neurons
Neurotrophic factors
neurotrophins
Older people
Review
therapeutics
SummonAdditionalLinks – databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NTtwwEB5RECoXVOgPC9sqSNyKVTtxNvEJrYAVQmpPIO0timNbIEGy3Q0HOPEavB5PwkzibFSh7ikHe6zRjD0zjme-ATjCA4aXAG1Yrl3BZBIbplMpWZobdBdcGyep3vn3n9HFtbycxlP_w23h0yo7m9gYalMV9I_8VziKBC6V8Phk9pdR1yh6XfUtND7ABkGXUUpXMk36ukjRAO1S1M8khha-aKYtnRPUxYwSFDjhwzD1r2N6F22-eyltHNDkE2z7yDEYt6regTVb7sJm20vycRc-nnat2z7D5KqvqgpmVU0ZQUhauaCBr6zn1ewGR3yvneC2DMZ3Tzf29t7OX59fFsFZ-2rzBa4n51enF8w3TGCF5GnNbOqMcVrFhkeKhM2Vzjl9XCyFDbkWJnQjw52S6BtdHudGOFfIwlF9bRR9hfWyKu0eBJFwIcF3RQbvU1rkqcLTjQSFlcakRTwA0UkrKzyaODW1uMt6HGSScIYSzhoJZ2oAP5c0sxZLY-XsYaeEzJ-rRdbvggEcLodRuvTMkZe2eqA5aJjCkUrUqjlouPAmnIgBfGsVvGSJ4H5wCaQ-7jTeM_B_fvdX83sAWyFVTjTpa0NYr-cP9jvGM7X-0WzaN8Ka8A0
  priority: 102
  providerName: ProQuest
Title Therapeutic potential of neurotrophic factors in Alzheimer’s Disease
URI https://link.springer.com/article/10.1007/s11033-021-06968-9
https://www.ncbi.nlm.nih.gov/pubmed/34826049
https://www.proquest.com/docview/2631475705
https://www.proquest.com/docview/2604026979
https://www.proquest.com/docview/2648844671
Volume 49
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlR3LTtwwcMRDVbmgQlvYQlep1FtryU6cTXzcwi4IVIQQK21PURzbAgmS1W44wInf6O_xJZ3JY6OKFomTD56xRjO2Z0bzAviKDwydAG1Yql3GZBQapmMpWZwaVBdcGyep3vnn2eB4Ik-m4bQpClu02e5tSLL6qbtiN0FzxyilgFNHF6ZWYT0k3x1v8cQfdtWQomqvS7Y-k2hQNKUy_z7jb3X0zMZ8Fh-t1M74HWw29qI3rAW8BSs234Y39QTJ-214e9AObHsP48uulsqbFSXlASFq4byqaWU5L2ZXuNNM2PGuc29483Blr2_t_Onx98I7rGM1H2AyHl0eHLNmTALLJI9LZmNnjNMqNDxQxGKudMppcaEU1udaGN8NDHdKokZ0aZga4VwmM0dVtUHwEdbyIre74AXC-dS0KzDoRWmRxgrfNCJkVhoTZ2EPRMutJGt6iNMoi5uk635MHE6Qw0nF4UT14NsSZ1Z30HgRer8VQtK8pkXiDwKB1yjiSMCX5TZyl4IbaW6LO4LB78gfqEi9BIPfFfq_kejBTi3gJUnU5AePQOzvrcQ7Av5P76fXge_Bhk_1E1US2z6slfM7-xmtmlL3YTWaRn1YHx79Oh3h-mN0dn7Rr672H5Gt8RU
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtQwcFRtVZULglLoQoEgwQms2omzGx8Q6mu1pe2qQluptzSObbVSSZbdVKic-A1-go_iSzqTx0ZVxd56ysEeazQznkfGMwPwHi8YBgHasES7lMl-aJiOpGRRYtBccG2cpHrn41FveCq_noVnS_C3qYWhZ5WNTiwVtclT-ke-5fcCgUf1efhl8oPR1CjKrjYjNCqxOLQ3PzFkm30-2EP-fvD9wf54d8jqqQIslTwqmI2cMU6r0PBAEUZc6YTTx4VSWJ9rYXzXM9wpiQbEJWFihHOpTB0VodIPUFT5yzLAUKYDyzv7o5NvbSWmKFv7UpzBJDozdZlOVawnaG4aPYng1JGGqbum8J5_ey83W5q8wRN4XPuq3nYlXE9hyWZrsFJNr7xZg9XdZljcMxiM2zoub5IX9AYJQXPnlQ0zi2k-ucCVerqPd5l521e_Luzldzv99_vPzNur8kTrcPogxHwOnSzP7AZ4gXA-NQwLDEZwWiSRQn2CAKmVxkRp2AXRUCtO6_7lNEbjKm47LxOFY6RwXFI4Vl34OIeZVN07Fu7ebJgQ1zd5Frdy14V382WkLiVWkszm17QHVaHfU321aA-qSoy9-6ILLyoGz1GiBkN4BEJ_ajjeIvB_fF8uxvctrA7Hx0fx0cHo8BU88qluo3w8twmdYnptX6M3Veg3tQh7cP7Qt-YWGYUwVQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LTtwwcIRApVxQS19LaZtK7alY2ImziQ-oQmxXUFrUA0h7C3FsCyRIlt0gBKf-Rn-ln8OXdCaPjRDq3jjlYI81Gs8zngfAJxQwDAK0Yal2GZNRaJiOpWRxatBccG2cpHrnn4f9vWP5fRSOFuBvWwtDaZWtTqwUtSky-ke-5fcDgUdFPNxyTVrEr8Hw6_iS0QQpemltx2nULHJgb64xfJtu7w_wrj_7_vDb0e4eayYMsEzyuGQ2dsY4rULDA0XYcaVTTh8XSmF9roXxXd9wpyQaE5eGqRHOZTJzVJBKP0NR_S9FQShIxqJR1NVkiqrJL0UcTKJb0xTs1GV7giaoUXIEp940TN03ig883QevtJXxGz6D1cZr9XZqNnsOCzZfgyf1HMubNXi6246NewHDo66iyxsXJWUjIWjhvKp1Zjkpxqe40sz58c5yb-f89tSeXdjJ3e8_U29Qvxi9hONHIeUrWMyL3L4BLxDOp9ZhgcFYTos0VqhZECCz0pg4C3sgWmolWdPJnAZqnCddD2aicIIUTioKJ6oHX2Yw47qPx9zdG-0lJI1MT5OOA3vwcbaM1KUnljS3xRXtQaXo91Wk5u1BpYlReCR68Lq-4BlK1GoIj0DozfbGOwT-j-_6fHw_wDLKSvJj__DgLaz4VMBRZdFtwGI5ubLv0K0q9fuKfz04eWyB-QcKbTMl
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Therapeutic+potential+of+neurotrophic+factors+in+Alzheimer%E2%80%99s+Disease&rft.jtitle=Molecular+biology+reports&rft.au=Nasrolahi%2C+Ava&rft.au=Javaherforooshzadeh%2C+Fatemeh&rft.au=Jafarzadeh-Gharehziaaddin%2C+Mohsen&rft.au=Mahmoudi%2C+Javad&rft.date=2022-03-01&rft.issn=0301-4851&rft.volume=49&rft.issue=3+p.2345-2357&rft.spage=2345&rft.epage=2357&rft_id=info:doi/10.1007%2Fs11033-021-06968-9&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0301-4851&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0301-4851&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0301-4851&client=summon