Whole Recombinant Saccharomyces cerevisiae Yeast Expressing Ras Mutations as Treatment for Patients With Solid Tumors Bearing Ras Mutations: Results From a Phase 1 Trial

• Published in: Journal of immunotherapy (1997) Vol. 41; no. 3; p. 141
• Main Authors: Cohn, Allen, Morse, Michael A, O'Neil, Bert, Whiting, Samuel, Coeshott, Claire, Ferraro, John, Bellgrau, Donald, Apelian, David, Rodell, Timothy C
• Format: Journal Article
• Language: English
• Published: United States 01.04.2018
• Subjects: Adult; Aged; Biological Therapy - methods; Biomarkers, Tumor; Complement Activation; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Immunity; Male; Middle Aged; Mutation; Neoplasms - genetics; Neoplasms - immunology; Neoplasms - pathology; Neoplasms - therapy; ras Proteins - genetics; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - immunology

We are developing whole, heat-killed, recombinant Saccharomyces cerevisiae yeast, engineered to encode target proteins, which stimulate immune responses against malignant cells expressing those targets. This phase 1 trial, enrolling patients with advanced colorectal or pancreas cancer, was designed...