Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection

• Published in: Immunity (Cambridge, Mass.) Vol. 56; no. 4; pp. 864 - 878.e4
• Main Authors: Gao, Fei, Mallajosyula, Vamsee, Arunachalam, Prabhu S., van der Ploeg, Kattria, Manohar, Monali, Röltgen, Katharina, Yang, Fan, Wirz, Oliver, Hoh, Ramona, Haraguchi, Emily, Lee, Ji-Yeun, Willis, Richard, Ramachandiran, Vasanthi, Li, Jiefu, Kathuria, Karan Raj, Li, Chunfeng, Lee, Alexandra S., Shah, Mihir M., Sindher, Sayantani B., Gonzalez, Joseph, Altman, John D., Wang, Taia T., Boyd, Scott D., Pulendran, Bali, Jagannathan, Prasanna, Nadeau, Kari C., Davis, Mark.M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.04.2023
• Subjects: Antibodies, Viral; antigen-specific T cell responses; BNT162 Vaccine; CD8-Positive T-Lymphocytes; COVID-19; Humans; peptide-MHC multimer; peripheral CD4+ T cell responses; peripheral CD8+ T cell responses; Pfizer/BioNTech mRNA vaccine; SARS-CoV-2; SARS-CoV-2 variants of concern; spheromer; Vaccination; Vaccines; COVID-19; peripheral CD8+ T cell responses; peptide-MHC multimer; SARS-CoV-2; antigen-specific T cell responses; SARS-CoV-2 variants of concern; peripheral CD4+ T cell responses; Pfizer/BioNTech mRNA vaccine; spheromer; peripheral CD4(+) T cell responses; peripheral CD8(+) T cell responses

T cells are a critical component of the response to SARS-CoV-2, but their kinetics after infection and vaccination are insufficiently understood. Using “spheromer” peptide-MHC multimer reagents, we analyzed healthy subjects receiving two doses of the Pfizer/BioNTech BNT162b2 vaccine. Vaccination res...