Grafting Segments from the Extracellular Surface of CCR5 onto a Bacteriorhodopsin Transmembrane Scaffold Confers HIV-1 Coreceptor Activity
Components from the extracellular surface of CCR5 interact with certain macrophage-tropic strains of human immunodeficiency virus type 1 (HIV-1) to mediate viral fusion and entry. To mimic these viral interacting site(s), the amino-terminal and extracellular loop segments of CCR5 were linked in tand...
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| Published in | Structure (London) Vol. 10; no. 4; pp. 515 - 525 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.04.2002
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Components from the extracellular surface of CCR5 interact with certain macrophage-tropic strains of human immunodeficiency virus type 1 (HIV-1) to mediate viral fusion and entry. To mimic these viral interacting site(s), the amino-terminal and extracellular loop segments of CCR5 were linked in tandem to form concatenated polypeptides, or grafted onto a seven-transmembrane bacteriorhodopsin scaffold to generate several chimeras. The chimera studies identified specific regions in CCR5 that confer HIV-1 coreceptor function, structural rearrangements in the transmembrane region that may modulate this activity, and a role for the extracellular surface in folding and assembly. Methods developed here may be applicable to the dissection of functional domains from other seven-transmembrane receptors and form a basis for future structural studies. |
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| AbstractList | Components from the extracellular surface of CCR5 interact with certain macrophage-tropic strains of human immunodeficiency virus type 1 (HIV-1) to mediate viral fusion and entry. To mimic these viral interacting site(s), the amino-terminal and extracellular loop segments of CCR5 were linked in tandem to form concatenated polypeptides, or grafted onto a seven-transmembrane bacteriorhodopsin scaffold to generate several chimeras. The chimera studies identified specific regions in CCR5 that confer HIV-1 coreceptor function, structural rearrangements in the transmembrane region that may modulate this activity, and a role for the extracellular surface in folding and assembly. Methods developed here may be applicable to the dissection of functional domains from other seven-transmembrane receptors and form a basis for future structural studies. |
| Author | Oprian, Daniel D Ngo, Tony Ridge, Kevin D Abdulaev, Najmoutin G Strassmaier, Timothy T Chen, Ruiwu Luecke, Hartmut |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11937056$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0021-9258(18)69178-1 10.1074/jbc.272.11.6854 10.1074/jbc.272.32.19771 10.1021/bi00272a020 10.1016/S0022-2836(05)80271-2 10.1074/jbc.274.40.28413 10.1128/JVI.72.4.3464-3468.1998 10.1126/science.280.5371.1934 10.1084/jem.186.8.1373 10.1073/pnas.90.5.1987 10.1146/annurev.biochem.69.1.881 10.1128/JVI.72.1.279-285.1998 10.1016/S0092-8674(00)80577-2 10.1128/JVI.71.7.5003-5011.1997 10.1099/0022-1317-82-8-1807 10.1016/S0021-9258(19)50491-4 10.1016/S0969-2126(00)00151-9 10.1074/jbc.272.40.24934 10.1126/science.289.5480.739 10.1146/annurev.immunol.17.1.657 10.1074/jbc.M005642200 10.1038/348411a0 10.1006/jmbi.2001.4603 10.1016/S0021-9258(19)81043-8 10.1073/pnas.94.10.5061 10.1016/S0021-9258(18)48074-X 10.1038/381661a0 10.1074/jbc.274.49.34719 10.1073/pnas.94.20.10571 10.1074/jbc.M007228200 10.1016/S0021-9258(18)34529-0 10.1016/0003-2697(77)90043-4 10.1073/pnas.84.24.8874 10.1023/A:1022411806090 10.1016/S0092-8674(00)81313-6 10.1128/JVI.73.4.3443-3448.1999 10.1016/S0092-8674(00)81364-1 10.1038/13324 10.1006/jmbi.2001.4604 10.1074/jbc.271.9.5059 10.1126/science.272.5270.1955 10.1126/science.277.5332.1676 10.1073/pnas.97.11.5762 10.1128/JVI.71.9.6305-6314.1997 10.1016/0378-1119(90)90456-2 10.1126/science.274.5294.1924 10.1093/emboj/16.10.2599 10.1074/jbc.271.29.17161 10.1038/31405 10.1074/jbc.273.28.17299 10.1074/jbc.274.14.9617 10.1073/pnas.87.13.4991 10.1128/JVI.73.5.4145-4155.1999 10.1016/S0014-5793(99)01685-3 10.1074/jbc.274.40.28745 10.1128/JVI.73.2.1645-1648.1999 10.1001/archopht.117.7.929 10.1016/S0092-8674(00)81314-8 10.1038/381667a0 10.1021/bi952950g 10.1073/pnas.95.20.11673 10.1128/JVI.72.2.1160-1164.1998 10.1006/jmbi.1999.3027 10.1126/science.272.5263.872 10.1016/S0021-9258(17)32083-5 10.1038/348419a0 10.1074/jbc.274.27.18902 |
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| Keywords | chimera G protein-coupled receptor HIV-1 CCR5 bacteriorhodopsin membrane protein folding |
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| References | Farzan, Mirzabekov, Kolchinsky, Wyatt, Cayabyab, Gerard, Gerard, Sodroski, Choe (BIB31) 1999; 96 Olson, Rabut, Nagashima, Tran, Anselma, Monard, Segal, Thompson, Kajumo, Guo (BIB25) 1999; 73 Luecke, Richter, Lanyi (BIB38) 1998; 280 Krebs, Mollaaghababa, Khorana (BIB41) 1993; 90 Henderson, Baldwin, Ceska, Zemlin, Beckmann, Downing (BIB36) 1990; 213 Dragic, Litwin, Allaway, Martin, Huang, Nagashima, Cayanan, Maddon, Koup, Moore, Paxton (BIB7) 1996; 381 Kimura, Mason, Khorana (BIB60) 1982; 257 Berger, Murphy, Farber (BIB10) 1999; 17 Raport, Gosling, Schweickart, Gray, Charo (BIB3) 1996; 271 Choe, Farzan, Sun, Sullivan, Rollins, Ponath, Wu, Mackay, LaRosa, Newman (BIB4) 1996; 85 Ferrer, Kapoor, Strassmaier, Weissenhorn, Skehel, Oprian, Schreiber, Wiley, Harrison (BIB64) 1999; 6 Rucker, Samson, Doranz, Libert, Berson, Yi, Smyth, Collman, Broder, Vassart (BIB17) 1996; 87 Doi, Molday, Khorana (BIB51) 1990; 87 Franke, Sakmar, Oprian, Khorana (BIB54) 1988; 263 London, Khorana (BIB63) 1982; 257 Palczewski, Kumasaka, Hori, Behnke, Motoshima, Fox, Le Trong, Teller, Okada, Stenkamp (BIB12) 2000; 289 Wang, Lee, Murray, Bonneau, Sun, Schweickart, Zhang, Peiper (BIB23) 1999; 274 Alkhatib, Combadiere, Broder, Feng, Kennedy, Murphy, Berger (BIB8) 1996; 272 Kwong, Wyatt, Robinson, Sweet, Sodroski, Hendrickson (BIB67) 1998; 393 Dragic, Trkola, Lin, Nagashima, Kajumo, Zhao, Olson, Wu, Mackay, Allaway (BIB26) 1998; 72 Ni, Chang, Duschl, Lanyi, Needleman (BIB40) 1990; 90 Essen, Siegert, Lehmann, Oesterhelt (BIB39) 1998; 95 Blanpain, Lee, Vakili, Doranz, Govaerts, Migeotte, Sharron, Dupriez, Vassart, Doms, Parmentier (BIB33) 1999; 274 Feng, Broder, Kennedy, Berger (BIB1) 1996; 272 Cormier, Persuh, Thompson, Lin, Sakmar, Olson, Dragic (BIB46) 2000; 97 Mirzabekov, Bannert, Farzan, Hofmann, Kolchinsky, Wu, Wyatt, Sodroski (BIB45) 1999; 274 Hwa, Garriga, Liu, Khorana (BIB53) 1997; 94 Abdulaev, Ngo, Chen, Lu, Ridge (BIB34) 2000; 275 Lu, DiBlasio-Smith, Grant, Warne, LaVallie, Collins-Racie, Follettie, Williamson, McCoy (BIB57) 1996; 271 Deng, Liu, Ellmeier, Choe, Unutmaz, Burkhart, Di Marzio, Marmon, Sutton, Hill (BIB6) 1996; 381 Wang, Yan, Garrett, Liu, Rodgers, Garlick, Tarr, Husain, Reinherz, Harrison (BIB65) 1990; 348 Rabut, Konner, Kajumo, Moore, Dragic (BIB28) 1998; 72 Alkhatib, Ahuja, Light, Mummidi, Berger, Ahuja (BIB22) 1997; 272 Kim, Booth, Allen, Khorana (BIB48) 2001; 308 Anukanth, Khorana (BIB52) 1994; 269 Zhang, Moore (BIB9) 1999; 73 Oprian, Molday, Kaufmann, Khorana (BIB58) 1987; 84 Pebay-Peyroula, Rummel, Rosenbusch, Landau (BIB37) 1997; 277 Ji, Grossman, Ji (BIB11) 1998; 273 Wu, LaRosa, Kassam, Gordon, Heath, Ruffing, Chen, Humblias, Samson, Parmentier (BIB19) 1997; 186 Farzan, Choe, Vaca, Martin, Sun, Desjardins, Ruffing, Wu, Wyatt, Gerard (BIB27) 1998; 72 Guy, Qi, Muzyczka, Hauswirth (BIB56) 1999; 117 Bieniasz, Fridell, Aramori, Ferguson, Caron, Cullen (BIB20) 1997; 16 Farzan, Choe, Martin, Sun, Sidelko, Mackay, Gerard, Sodroski, Gerard (BIB15) 1997; 272 Samson, LaRosa, Libert, Paindavoine, Detheux, Vassart, Parmentier (BIB32) 1997; 272 Farzan, Vasilieva, Schnitzler, Chung, Robinson, Gerard, Gerard, Choe, Sodroski (BIB47) 2000; 275 Picard, Simmons, Power, Meyer, Weiss, Clapham (BIB21) 1997; 71 Genoud, Kajumo, Guo, Thompson, Dragic (BIB29) 1999; 73 Peterson (BIB61) 1977; 83 Doranz, Lu, Rucker, Zhang, Sharron, Cen, Wang, Guo, Du, Accavitti (BIB18) 1997; 71 Lanyi (BIB35) 1999; 464 Heymann, Jager, Subramaniam (BIB44) 1997; 29 Doranz, Rucker, Yi, Smyth, Samson, Peiper, Parmentier, Collman, Doms (BIB5) 1996; 85 Dragic (BIB13) 2001; 82 Molday, McKenzie (BIB59) 1983; 22 Lee, Sharron, Blanpain, Doranz, Vakili, Setoh, Berg, Liu, Guy, Durell (BIB24) 1999; 274 Heymann, Pfeiffer, Hildebrandt, Kaback, Fotiadis, Groot, Engel, Oesterhelt, Muller (BIB42) 2000; 8 Allen, Kim, Khorana, Lu, Booth (BIB49) 2001; 308 Atchison, Gosling, Monteclaro, Franci, Digilio, Charo, Goldsmith (BIB14) 1996; 274 Bhattacharya, Ridge, Knox, Khorana (BIB62) 1992; 267 Ryu, Kwong, Truneh, Porter, Arthos, Rosenberg, Dai, Xuong, Axel, Sweet (BIB66) 1990; 348 Blanpain, Doranz, Vakili, Rucker, Govaerts, Baik, Lorthioir, Migeotte, Libert, Baleux (BIB30) 1999; 274 Popot, Engelman (BIB50) 2000; 69 Karnik, Nassal, Doi, Jay, Sgaramella, Khorana (BIB55) 1987; 262 Samson, Labbe, Mollereau, Vassart, Parmentier (BIB2) 1996; 35 Gosling, Monteclaro, Atchison, Arai, Tsou, Goldsmith, Charo (BIB16) 1997; 94 Luecke, Schobert, Richter, Cartailler, Lanyi (BIB43) 1999; 291 Franke (10.1016/S0969-2126(02)00752-9_BIB54) 1988; 263 Cormier (10.1016/S0969-2126(02)00752-9_BIB46) 2000; 97 Doi (10.1016/S0969-2126(02)00752-9_BIB51) 1990; 87 Karnik (10.1016/S0969-2126(02)00752-9_BIB55) 1987; 262 Luecke (10.1016/S0969-2126(02)00752-9_BIB38) 1998; 280 Doranz (10.1016/S0969-2126(02)00752-9_BIB5) 1996; 85 Kimura (10.1016/S0969-2126(02)00752-9_BIB60) 1982; 257 Ferrer (10.1016/S0969-2126(02)00752-9_BIB64) 1999; 6 Doranz (10.1016/S0969-2126(02)00752-9_BIB18) 1997; 71 Farzan (10.1016/S0969-2126(02)00752-9_BIB31) 1999; 96 Peterson (10.1016/S0969-2126(02)00752-9_BIB61) 1977; 83 Bhattacharya (10.1016/S0969-2126(02)00752-9_BIB62) 1992; 267 Ji (10.1016/S0969-2126(02)00752-9_BIB11) 1998; 273 Krebs (10.1016/S0969-2126(02)00752-9_BIB41) 1993; 90 Hwa (10.1016/S0969-2126(02)00752-9_BIB53) 1997; 94 Choe (10.1016/S0969-2126(02)00752-9_BIB4) 1996; 85 Dragic (10.1016/S0969-2126(02)00752-9_BIB7) 1996; 381 Molday (10.1016/S0969-2126(02)00752-9_BIB59) 1983; 22 Kim (10.1016/S0969-2126(02)00752-9_BIB48) 2001; 308 Dragic (10.1016/S0969-2126(02)00752-9_BIB26) 1998; 72 Essen (10.1016/S0969-2126(02)00752-9_BIB39) 1998; 95 Bieniasz (10.1016/S0969-2126(02)00752-9_BIB20) 1997; 16 Henderson (10.1016/S0969-2126(02)00752-9_BIB36) 1990; 213 Heymann (10.1016/S0969-2126(02)00752-9_BIB42) 2000; 8 Deng (10.1016/S0969-2126(02)00752-9_BIB6) 1996; 381 Picard (10.1016/S0969-2126(02)00752-9_BIB21) 1997; 71 Lee (10.1016/S0969-2126(02)00752-9_BIB24) 1999; 274 Anukanth (10.1016/S0969-2126(02)00752-9_BIB52) 1994; 269 Oprian (10.1016/S0969-2126(02)00752-9_BIB58) 1987; 84 Berger (10.1016/S0969-2126(02)00752-9_BIB10) 1999; 17 London (10.1016/S0969-2126(02)00752-9_BIB63) 1982; 257 Ryu (10.1016/S0969-2126(02)00752-9_BIB66) 1990; 348 Zhang (10.1016/S0969-2126(02)00752-9_BIB9) 1999; 73 Blanpain (10.1016/S0969-2126(02)00752-9_BIB30) 1999; 274 Farzan (10.1016/S0969-2126(02)00752-9_BIB47) 2000; 275 Heymann (10.1016/S0969-2126(02)00752-9_BIB44) 1997; 29 Atchison (10.1016/S0969-2126(02)00752-9_BIB14) 1996; 274 Palczewski (10.1016/S0969-2126(02)00752-9_BIB12) 2000; 289 Dragic (10.1016/S0969-2126(02)00752-9_BIB13) 2001; 82 Rabut (10.1016/S0969-2126(02)00752-9_BIB28) 1998; 72 Guy (10.1016/S0969-2126(02)00752-9_BIB56) 1999; 117 Farzan (10.1016/S0969-2126(02)00752-9_BIB27) 1998; 72 Abdulaev (10.1016/S0969-2126(02)00752-9_BIB34) 2000; 275 Luecke (10.1016/S0969-2126(02)00752-9_BIB43) 1999; 291 Samson (10.1016/S0969-2126(02)00752-9_BIB2) 1996; 35 Rucker (10.1016/S0969-2126(02)00752-9_BIB17) 1996; 87 Gosling (10.1016/S0969-2126(02)00752-9_BIB16) 1997; 94 Blanpain (10.1016/S0969-2126(02)00752-9_BIB33) 1999; 274 Wu (10.1016/S0969-2126(02)00752-9_BIB19) 1997; 186 Feng (10.1016/S0969-2126(02)00752-9_BIB1) 1996; 272 Wang (10.1016/S0969-2126(02)00752-9_BIB65) 1990; 348 Alkhatib (10.1016/S0969-2126(02)00752-9_BIB22) 1997; 272 Samson (10.1016/S0969-2126(02)00752-9_BIB32) 1997; 272 Popot (10.1016/S0969-2126(02)00752-9_BIB50) 2000; 69 Lanyi (10.1016/S0969-2126(02)00752-9_BIB35) 1999; 464 Raport (10.1016/S0969-2126(02)00752-9_BIB3) 1996; 271 Allen (10.1016/S0969-2126(02)00752-9_BIB49) 2001; 308 Farzan (10.1016/S0969-2126(02)00752-9_BIB15) 1997; 272 Kwong (10.1016/S0969-2126(02)00752-9_BIB67) 1998; 393 Olson (10.1016/S0969-2126(02)00752-9_BIB25) 1999; 73 Wang (10.1016/S0969-2126(02)00752-9_BIB23) 1999; 274 Ni (10.1016/S0969-2126(02)00752-9_BIB40) 1990; 90 Pebay-Peyroula (10.1016/S0969-2126(02)00752-9_BIB37) 1997; 277 Alkhatib (10.1016/S0969-2126(02)00752-9_BIB8) 1996; 272 Lu (10.1016/S0969-2126(02)00752-9_BIB57) 1996; 271 Genoud (10.1016/S0969-2126(02)00752-9_BIB29) 1999; 73 Mirzabekov (10.1016/S0969-2126(02)00752-9_BIB45) 1999; 274 |
| References_xml | – volume: 274 start-page: 34719 year: 1999 end-page: 34727 ident: BIB30 article-title: Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein publication-title: J. Biol. Chem. contributor: fullname: Baleux – volume: 96 start-page: 667 year: 1999 end-page: 676 ident: BIB31 article-title: Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry publication-title: Cell contributor: fullname: Choe – volume: 348 start-page: 411 year: 1990 end-page: 418 ident: BIB65 article-title: Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains publication-title: Nature contributor: fullname: Harrison – volume: 71 start-page: 5003 year: 1997 end-page: 5011 ident: BIB21 article-title: Multiple extracellular domains of CCR-5 contribute to human immunodeficiency virus type 1 entry and fusion publication-title: J. Virol. contributor: fullname: Clapham – volume: 381 start-page: 667 year: 1996 end-page: 673 ident: BIB7 article-title: HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5 publication-title: Nature contributor: fullname: Paxton – volume: 272 start-page: 872 year: 1996 end-page: 877 ident: BIB1 article-title: HIV-1 entry cofactor publication-title: Science contributor: fullname: Berger – volume: 82 start-page: 1807 year: 2001 end-page: 1814 ident: BIB13 article-title: An overview of the determinants of CCR5 and CXCR4 co-receptor function publication-title: J. Gen. Virol. contributor: fullname: Dragic – volume: 186 start-page: 1373 year: 1997 end-page: 1381 ident: BIB19 article-title: Interaction of chemokine receptor CCR5 with its ligands publication-title: J. Exp. Med. contributor: fullname: Parmentier – volume: 275 start-page: 39354 year: 2000 end-page: 39363 ident: BIB34 article-title: Functionally discrete mimics of light-activated rhodopsin identified through expression of soluble cytoplasmic domains publication-title: J. Biol. Chem. contributor: fullname: Ridge – volume: 262 start-page: 9255 year: 1987 end-page: 9263 ident: BIB55 article-title: Structure-function studies on bacteriorhodopsin. II. Improved expression of the bacterio-opsin gene in publication-title: J. Biol. Chem. contributor: fullname: Khorana – volume: 274 start-page: 1924 year: 1996 end-page: 1926 ident: BIB14 article-title: Multiple extracellular elements of CCR5 and HIV-1 entry publication-title: Science contributor: fullname: Goldsmith – volume: 213 start-page: 899 year: 1990 end-page: 929 ident: BIB36 article-title: Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy publication-title: J. Mol. Biol. contributor: fullname: Downing – volume: 257 start-page: 7003 year: 1982 end-page: 7011 ident: BIB63 article-title: Denaturation and renaturation of bacteriorhodopsin in detergents and lipid-detergent mixtures publication-title: J. Biol. Chem. contributor: fullname: Khorana – volume: 97 start-page: 5762 year: 2000 end-page: 5767 ident: BIB46 article-title: Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Dragic – volume: 94 start-page: 10571 year: 1997 end-page: 10576 ident: BIB53 article-title: Structure and function in rhodopsin publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Khorana – volume: 95 start-page: 11673 year: 1998 end-page: 11678 ident: BIB39 article-title: Lipid patches in membrane protein oligomers publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Oesterhelt – volume: 83 start-page: 346 year: 1977 end-page: 356 ident: BIB61 article-title: A simplification of the protein assay method of Lowry et al. which is more generally applicable publication-title: Anal. Biochem. contributor: fullname: Peterson – volume: 381 start-page: 661 year: 1996 end-page: 666 ident: BIB6 article-title: Identification of a major co-receptor for primary isolates of HIV-1 publication-title: Nature contributor: fullname: Hill – volume: 272 start-page: 6854 year: 1997 end-page: 6857 ident: BIB15 article-title: HIV-1 entry and macrophage inflammatory protein-1β-mediated signaling are independent functions of the chemokine receptor CCR5 publication-title: J. Biol. Chem. contributor: fullname: Gerard – volume: 274 start-page: 28413 year: 1999 end-page: 28419 ident: BIB23 article-title: CCR5 HIV-1 coreceptor activity. Role of cooperativity between residues in N-terminal extracellular and intracellular domains publication-title: J. Biol. Chem. contributor: fullname: Peiper – volume: 87 start-page: 4991 year: 1990 end-page: 4995 ident: BIB51 article-title: Role of the intradiscal domain in rhodopsin assembly and function publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Khorana – volume: 69 start-page: 881 year: 2000 end-page: 922 ident: BIB50 article-title: Helical membrane protein folding, stability, and evolution publication-title: Annu. Rev. Biochem. contributor: fullname: Engelman – volume: 73 start-page: 3443 year: 1999 end-page: 3448 ident: BIB9 article-title: Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry? publication-title: J. Virol. contributor: fullname: Moore – volume: 87 start-page: 437 year: 1996 end-page: 446 ident: BIB17 article-title: Regions in β-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity publication-title: Cell contributor: fullname: Vassart – volume: 263 start-page: 2119 year: 1988 end-page: 2122 ident: BIB54 article-title: A single amino acid substitution in rhodopsin (lysine 248 to leucine) prevents activation of transducin publication-title: J. Biol. Chem. contributor: fullname: Khorana – volume: 291 start-page: 899 year: 1999 end-page: 911 ident: BIB43 article-title: Structure of bacteriorhodopsin at 1.55 Å resolution publication-title: J. Mol. Biol. contributor: fullname: Lanyi – volume: 308 start-page: 409 year: 2001 end-page: 422 ident: BIB48 article-title: Structure and function in bacteriorhodopsin publication-title: J. Mol. Biol. contributor: fullname: Khorana – volume: 22 start-page: 653 year: 1983 end-page: 660 ident: BIB59 article-title: Monoclonal antibodies to rhodopsin publication-title: Biochemistry contributor: fullname: McKenzie – volume: 71 start-page: 6305 year: 1997 end-page: 6314 ident: BIB18 article-title: Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1 publication-title: J. Virol. contributor: fullname: Accavitti – volume: 72 start-page: 3464 year: 1998 end-page: 3468 ident: BIB28 article-title: Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage- and dualtropic isolates of human immunodeficiency virus type 1 publication-title: J. Virol. contributor: fullname: Dragic – volume: 272 start-page: 19771 year: 1997 end-page: 19776 ident: BIB22 article-title: CC chemokine receptor 5-mediated signaling and HIV-1 co-receptor activity share common structural determinants. Critical residues in the third extracellular loop support HIV-1 fusion publication-title: J. Biol. Chem. contributor: fullname: Ahuja – volume: 272 start-page: 1955 year: 1996 end-page: 1958 ident: BIB8 article-title: Cc CKR5 publication-title: Science contributor: fullname: Berger – volume: 90 start-page: 169 year: 1990 end-page: 172 ident: BIB40 article-title: An efficient system for the synthesis of bacteriorhodopsin in publication-title: Gene contributor: fullname: Needleman – volume: 73 start-page: 1645 year: 1999 end-page: 1648 ident: BIB29 article-title: CCR5-mediated human immunodeficiency virus entry depends on an amino-terminal gp120-binding site and on the conformational integrity of all four extracellular domains publication-title: J. Virol. contributor: fullname: Dragic – volume: 94 start-page: 5061 year: 1997 end-page: 5066 ident: BIB16 article-title: Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Charo – volume: 348 start-page: 419 year: 1990 end-page: 426 ident: BIB66 article-title: Crystal structure of an HIV-binding recombinant fragment of human CD4 publication-title: Nature contributor: fullname: Sweet – volume: 280 start-page: 1934 year: 1998 end-page: 1937 ident: BIB38 article-title: Proton transfer pathways in bacteriorhodopsin at 2.3 angstrom resolution publication-title: Science contributor: fullname: Lanyi – volume: 17 start-page: 657 year: 1999 end-page: 700 ident: BIB10 article-title: Chemokine receptors as HIV-1 coreceptors publication-title: Annu. Rev. Immunol. contributor: fullname: Farber – volume: 73 start-page: 4145 year: 1999 end-page: 4155 ident: BIB25 article-title: Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5 publication-title: J. Virol. contributor: fullname: Guo – volume: 72 start-page: 1160 year: 1998 end-page: 1164 ident: BIB27 article-title: A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5 publication-title: J. Virol. contributor: fullname: Gerard – volume: 393 start-page: 648 year: 1998 end-page: 659 ident: BIB67 article-title: Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody publication-title: Nature contributor: fullname: Hendrickson – volume: 271 start-page: 17161 year: 1996 end-page: 17166 ident: BIB3 article-title: Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1β, and MIP-1α publication-title: J. Biol. Chem. contributor: fullname: Charo – volume: 271 start-page: 5059 year: 1996 end-page: 5065 ident: BIB57 article-title: Histidine patch thioredoxins. Mutant forms of thioredoxin with metal chelating affinity that provide for convenient purifications of thioredoxin fusion proteins publication-title: J. Biol. Chem. contributor: fullname: McCoy – volume: 8 start-page: 643 year: 2000 end-page: 653 ident: BIB42 article-title: Conformations of the rhodopsin third cytoplasmic loop grafted onto bacteriorhodopsin publication-title: Structure Fold. Des. contributor: fullname: Muller – volume: 274 start-page: 28745 year: 1999 end-page: 28750 ident: BIB45 article-title: Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor publication-title: J. Biol. Chem. contributor: fullname: Sodroski – volume: 90 start-page: 1987 year: 1993 end-page: 1991 ident: BIB41 article-title: Gene replacement publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Khorana – volume: 267 start-page: 6763 year: 1992 end-page: 6769 ident: BIB62 article-title: Light-stable rhodopsin. I. A rhodopsin analog reconstituted with a nonisomerizable 11-cis retinal derivative publication-title: J. Biol. Chem. contributor: fullname: Khorana – volume: 85 start-page: 1149 year: 1996 end-page: 1158 ident: BIB5 article-title: A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors publication-title: Cell contributor: fullname: Doms – volume: 289 start-page: 739 year: 2000 end-page: 745 ident: BIB12 article-title: Crystal structure of rhodopsin publication-title: Science contributor: fullname: Stenkamp – volume: 16 start-page: 2599 year: 1997 end-page: 2609 ident: BIB20 article-title: HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor publication-title: EMBO J. contributor: fullname: Cullen – volume: 269 start-page: 19738 year: 1994 end-page: 19744 ident: BIB52 article-title: Structure and function in rhodopsin. Requirements of a specific structure for the intradiscal domain publication-title: J. Biol. Chem. contributor: fullname: Khorana – volume: 35 start-page: 3362 year: 1996 end-page: 3367 ident: BIB2 article-title: Molecular cloning and functional expression of a new human CC-chemokine receptor gene publication-title: Biochemistry contributor: fullname: Parmentier – volume: 274 start-page: 18902 year: 1999 end-page: 18908 ident: BIB33 article-title: Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity publication-title: J. Biol. Chem. contributor: fullname: Parmentier – volume: 117 start-page: 929 year: 1999 end-page: 937 ident: BIB56 article-title: Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve publication-title: Arch. Ophthalmol. contributor: fullname: Hauswirth – volume: 257 start-page: 2859 year: 1982 end-page: 2867 ident: BIB60 article-title: Immunological probes for bacteriorhodopsin. Identification of three distinct antigenic sites on the cytoplasmic surface publication-title: J. Biol. Chem. contributor: fullname: Khorana – volume: 275 start-page: 33516 year: 2000 end-page: 33521 ident: BIB47 article-title: A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry publication-title: J. Biol. Chem. contributor: fullname: Sodroski – volume: 85 start-page: 1135 year: 1996 end-page: 1148 ident: BIB4 article-title: The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates publication-title: Cell contributor: fullname: Newman – volume: 274 start-page: 9617 year: 1999 end-page: 9626 ident: BIB24 article-title: Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function publication-title: J. Biol. Chem. contributor: fullname: Durell – volume: 72 start-page: 279 year: 1998 end-page: 285 ident: BIB26 article-title: Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry publication-title: J. Virol. contributor: fullname: Allaway – volume: 272 start-page: 24934 year: 1997 end-page: 24941 ident: BIB32 article-title: The second extracellular loop of CCR5 is the major determinant of ligand specificity publication-title: J. Biol. Chem. contributor: fullname: Parmentier – volume: 29 start-page: 55 year: 1997 end-page: 59 ident: BIB44 article-title: Expression of bacteriorhodopsin in Sf9 and COS-1 cells publication-title: J. Bioenerg. Biomembr. contributor: fullname: Subramaniam – volume: 308 start-page: 423 year: 2001 end-page: 435 ident: BIB49 article-title: Structure and function in bacteriorhodopsin publication-title: J. Mol. Biol. contributor: fullname: Booth – volume: 277 start-page: 1676 year: 1997 end-page: 1681 ident: BIB37 article-title: X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases publication-title: Science contributor: fullname: Landau – volume: 464 start-page: 103 year: 1999 end-page: 107 ident: BIB35 article-title: Progress toward an explicit mechanistic model for the light-driven pump, bacteriorhodopsin publication-title: FEBS Lett. contributor: fullname: Lanyi – volume: 273 start-page: 17299 year: 1998 end-page: 17302 ident: BIB11 article-title: G protein-coupled receptors. I. Diversity of receptor-ligand interactions publication-title: J. Biol. Chem. contributor: fullname: Ji – volume: 84 start-page: 8874 year: 1987 end-page: 8878 ident: BIB58 article-title: Expression of a synthetic bovine rhodopsin gene in monkey kidney cells publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Khorana – volume: 6 start-page: 953 year: 1999 end-page: 960 ident: BIB64 article-title: Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements publication-title: Nat. Struct. Biol. contributor: fullname: Harrison – volume: 263 start-page: 2119 year: 1988 ident: 10.1016/S0969-2126(02)00752-9_BIB54 article-title: A single amino acid substitution in rhodopsin (lysine 248 to leucine) prevents activation of transducin publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)69178-1 contributor: fullname: Franke – volume: 272 start-page: 6854 year: 1997 ident: 10.1016/S0969-2126(02)00752-9_BIB15 article-title: HIV-1 entry and macrophage inflammatory protein-1β-mediated signaling are independent functions of the chemokine receptor CCR5 publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.11.6854 contributor: fullname: Farzan – volume: 272 start-page: 19771 year: 1997 ident: 10.1016/S0969-2126(02)00752-9_BIB22 article-title: CC chemokine receptor 5-mediated signaling and HIV-1 co-receptor activity share common structural determinants. Critical residues in the third extracellular loop support HIV-1 fusion publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.32.19771 contributor: fullname: Alkhatib – volume: 22 start-page: 653 year: 1983 ident: 10.1016/S0969-2126(02)00752-9_BIB59 article-title: Monoclonal antibodies to rhodopsin publication-title: Biochemistry doi: 10.1021/bi00272a020 contributor: fullname: Molday – volume: 213 start-page: 899 year: 1990 ident: 10.1016/S0969-2126(02)00752-9_BIB36 article-title: Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy publication-title: J. Mol. Biol. doi: 10.1016/S0022-2836(05)80271-2 contributor: fullname: Henderson – volume: 274 start-page: 28413 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB23 article-title: CCR5 HIV-1 coreceptor activity. Role of cooperativity between residues in N-terminal extracellular and intracellular domains publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.40.28413 contributor: fullname: Wang – volume: 72 start-page: 3464 year: 1998 ident: 10.1016/S0969-2126(02)00752-9_BIB28 article-title: Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage- and dualtropic isolates of human immunodeficiency virus type 1 publication-title: J. Virol. doi: 10.1128/JVI.72.4.3464-3468.1998 contributor: fullname: Rabut – volume: 280 start-page: 1934 year: 1998 ident: 10.1016/S0969-2126(02)00752-9_BIB38 article-title: Proton transfer pathways in bacteriorhodopsin at 2.3 angstrom resolution publication-title: Science doi: 10.1126/science.280.5371.1934 contributor: fullname: Luecke – volume: 186 start-page: 1373 year: 1997 ident: 10.1016/S0969-2126(02)00752-9_BIB19 article-title: Interaction of chemokine receptor CCR5 with its ligands publication-title: J. Exp. Med. doi: 10.1084/jem.186.8.1373 contributor: fullname: Wu – volume: 90 start-page: 1987 year: 1993 ident: 10.1016/S0969-2126(02)00752-9_BIB41 article-title: Gene replacement in Halobacterium halobium and expression of bacteriorhodopsin mutants publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.90.5.1987 contributor: fullname: Krebs – volume: 69 start-page: 881 year: 2000 ident: 10.1016/S0969-2126(02)00752-9_BIB50 article-title: Helical membrane protein folding, stability, and evolution publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.69.1.881 contributor: fullname: Popot – volume: 72 start-page: 279 year: 1998 ident: 10.1016/S0969-2126(02)00752-9_BIB26 article-title: Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry publication-title: J. Virol. doi: 10.1128/JVI.72.1.279-285.1998 contributor: fullname: Dragic – volume: 96 start-page: 667 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB31 article-title: Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry publication-title: Cell doi: 10.1016/S0092-8674(00)80577-2 contributor: fullname: Farzan – volume: 71 start-page: 5003 year: 1997 ident: 10.1016/S0969-2126(02)00752-9_BIB21 article-title: Multiple extracellular domains of CCR-5 contribute to human immunodeficiency virus type 1 entry and fusion publication-title: J. Virol. doi: 10.1128/JVI.71.7.5003-5011.1997 contributor: fullname: Picard – volume: 82 start-page: 1807 year: 2001 ident: 10.1016/S0969-2126(02)00752-9_BIB13 article-title: An overview of the determinants of CCR5 and CXCR4 co-receptor function publication-title: J. Gen. Virol. doi: 10.1099/0022-1317-82-8-1807 contributor: fullname: Dragic – volume: 267 start-page: 6763 year: 1992 ident: 10.1016/S0969-2126(02)00752-9_BIB62 article-title: Light-stable rhodopsin. I. A rhodopsin analog reconstituted with a nonisomerizable 11-cis retinal derivative publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)50491-4 contributor: fullname: Bhattacharya – volume: 8 start-page: 643 year: 2000 ident: 10.1016/S0969-2126(02)00752-9_BIB42 article-title: Conformations of the rhodopsin third cytoplasmic loop grafted onto bacteriorhodopsin publication-title: Structure Fold. Des. doi: 10.1016/S0969-2126(00)00151-9 contributor: fullname: Heymann – volume: 272 start-page: 24934 year: 1997 ident: 10.1016/S0969-2126(02)00752-9_BIB32 article-title: The second extracellular loop of CCR5 is the major determinant of ligand specificity publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.40.24934 contributor: fullname: Samson – volume: 289 start-page: 739 year: 2000 ident: 10.1016/S0969-2126(02)00752-9_BIB12 article-title: Crystal structure of rhodopsin publication-title: Science doi: 10.1126/science.289.5480.739 contributor: fullname: Palczewski – volume: 17 start-page: 657 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB10 article-title: Chemokine receptors as HIV-1 coreceptors publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.17.1.657 contributor: fullname: Berger – volume: 275 start-page: 39354 year: 2000 ident: 10.1016/S0969-2126(02)00752-9_BIB34 article-title: Functionally discrete mimics of light-activated rhodopsin identified through expression of soluble cytoplasmic domains publication-title: J. Biol. Chem. doi: 10.1074/jbc.M005642200 contributor: fullname: Abdulaev – volume: 348 start-page: 411 year: 1990 ident: 10.1016/S0969-2126(02)00752-9_BIB65 article-title: Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains publication-title: Nature doi: 10.1038/348411a0 contributor: fullname: Wang – volume: 308 start-page: 409 year: 2001 ident: 10.1016/S0969-2126(02)00752-9_BIB48 article-title: Structure and function in bacteriorhodopsin publication-title: J. Mol. Biol. doi: 10.1006/jmbi.2001.4603 contributor: fullname: Kim – volume: 257 start-page: 2859 year: 1982 ident: 10.1016/S0969-2126(02)00752-9_BIB60 article-title: Immunological probes for bacteriorhodopsin. Identification of three distinct antigenic sites on the cytoplasmic surface publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)81043-8 contributor: fullname: Kimura – volume: 94 start-page: 5061 year: 1997 ident: 10.1016/S0969-2126(02)00752-9_BIB16 article-title: Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.94.10.5061 contributor: fullname: Gosling – volume: 262 start-page: 9255 year: 1987 ident: 10.1016/S0969-2126(02)00752-9_BIB55 article-title: Structure-function studies on bacteriorhodopsin. II. Improved expression of the bacterio-opsin gene in Escherichia coli publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)48074-X contributor: fullname: Karnik – volume: 381 start-page: 661 year: 1996 ident: 10.1016/S0969-2126(02)00752-9_BIB6 article-title: Identification of a major co-receptor for primary isolates of HIV-1 publication-title: Nature doi: 10.1038/381661a0 contributor: fullname: Deng – volume: 274 start-page: 34719 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB30 article-title: Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.49.34719 contributor: fullname: Blanpain – volume: 94 start-page: 10571 year: 1997 ident: 10.1016/S0969-2126(02)00752-9_BIB53 article-title: Structure and function in rhodopsin publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.94.20.10571 contributor: fullname: Hwa – volume: 275 start-page: 33516 year: 2000 ident: 10.1016/S0969-2126(02)00752-9_BIB47 article-title: A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry publication-title: J. Biol. Chem. doi: 10.1074/jbc.M007228200 contributor: fullname: Farzan – volume: 257 start-page: 7003 year: 1982 ident: 10.1016/S0969-2126(02)00752-9_BIB63 article-title: Denaturation and renaturation of bacteriorhodopsin in detergents and lipid-detergent mixtures publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)34529-0 contributor: fullname: London – volume: 83 start-page: 346 year: 1977 ident: 10.1016/S0969-2126(02)00752-9_BIB61 article-title: A simplification of the protein assay method of Lowry et al. which is more generally applicable publication-title: Anal. Biochem. doi: 10.1016/0003-2697(77)90043-4 contributor: fullname: Peterson – volume: 84 start-page: 8874 year: 1987 ident: 10.1016/S0969-2126(02)00752-9_BIB58 article-title: Expression of a synthetic bovine rhodopsin gene in monkey kidney cells publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.84.24.8874 contributor: fullname: Oprian – volume: 29 start-page: 55 year: 1997 ident: 10.1016/S0969-2126(02)00752-9_BIB44 article-title: Expression of bacteriorhodopsin in Sf9 and COS-1 cells publication-title: J. Bioenerg. Biomembr. doi: 10.1023/A:1022411806090 contributor: fullname: Heymann – volume: 85 start-page: 1135 year: 1996 ident: 10.1016/S0969-2126(02)00752-9_BIB4 article-title: The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates publication-title: Cell doi: 10.1016/S0092-8674(00)81313-6 contributor: fullname: Choe – volume: 73 start-page: 3443 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB9 article-title: Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry? publication-title: J. Virol. doi: 10.1128/JVI.73.4.3443-3448.1999 contributor: fullname: Zhang – volume: 87 start-page: 437 year: 1996 ident: 10.1016/S0969-2126(02)00752-9_BIB17 article-title: Regions in β-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity publication-title: Cell doi: 10.1016/S0092-8674(00)81364-1 contributor: fullname: Rucker – volume: 6 start-page: 953 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB64 article-title: Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements publication-title: Nat. Struct. Biol. doi: 10.1038/13324 contributor: fullname: Ferrer – volume: 308 start-page: 423 year: 2001 ident: 10.1016/S0969-2126(02)00752-9_BIB49 article-title: Structure and function in bacteriorhodopsin publication-title: J. Mol. Biol. doi: 10.1006/jmbi.2001.4604 contributor: fullname: Allen – volume: 271 start-page: 5059 year: 1996 ident: 10.1016/S0969-2126(02)00752-9_BIB57 article-title: Histidine patch thioredoxins. Mutant forms of thioredoxin with metal chelating affinity that provide for convenient purifications of thioredoxin fusion proteins publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.9.5059 contributor: fullname: Lu – volume: 272 start-page: 1955 year: 1996 ident: 10.1016/S0969-2126(02)00752-9_BIB8 article-title: Cc CKR5 publication-title: Science doi: 10.1126/science.272.5270.1955 contributor: fullname: Alkhatib – volume: 277 start-page: 1676 year: 1997 ident: 10.1016/S0969-2126(02)00752-9_BIB37 article-title: X-ray structure of bacteriorhodopsin at 2.5 angstroms from microcrystals grown in lipidic cubic phases publication-title: Science doi: 10.1126/science.277.5332.1676 contributor: fullname: Pebay-Peyroula – volume: 97 start-page: 5762 year: 2000 ident: 10.1016/S0969-2126(02)00752-9_BIB46 article-title: Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.97.11.5762 contributor: fullname: Cormier – volume: 71 start-page: 6305 year: 1997 ident: 10.1016/S0969-2126(02)00752-9_BIB18 article-title: Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1 publication-title: J. Virol. doi: 10.1128/JVI.71.9.6305-6314.1997 contributor: fullname: Doranz – volume: 90 start-page: 169 year: 1990 ident: 10.1016/S0969-2126(02)00752-9_BIB40 article-title: An efficient system for the synthesis of bacteriorhodopsin in Halobacterium halobium publication-title: Gene doi: 10.1016/0378-1119(90)90456-2 contributor: fullname: Ni – volume: 274 start-page: 1924 year: 1996 ident: 10.1016/S0969-2126(02)00752-9_BIB14 article-title: Multiple extracellular elements of CCR5 and HIV-1 entry publication-title: Science doi: 10.1126/science.274.5294.1924 contributor: fullname: Atchison – volume: 16 start-page: 2599 year: 1997 ident: 10.1016/S0969-2126(02)00752-9_BIB20 article-title: HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor publication-title: EMBO J. doi: 10.1093/emboj/16.10.2599 contributor: fullname: Bieniasz – volume: 271 start-page: 17161 year: 1996 ident: 10.1016/S0969-2126(02)00752-9_BIB3 article-title: Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1β, and MIP-1α publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.29.17161 contributor: fullname: Raport – volume: 393 start-page: 648 year: 1998 ident: 10.1016/S0969-2126(02)00752-9_BIB67 article-title: Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody publication-title: Nature doi: 10.1038/31405 contributor: fullname: Kwong – volume: 273 start-page: 17299 year: 1998 ident: 10.1016/S0969-2126(02)00752-9_BIB11 article-title: G protein-coupled receptors. I. Diversity of receptor-ligand interactions publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.28.17299 contributor: fullname: Ji – volume: 274 start-page: 9617 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB24 article-title: Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.14.9617 contributor: fullname: Lee – volume: 87 start-page: 4991 year: 1990 ident: 10.1016/S0969-2126(02)00752-9_BIB51 article-title: Role of the intradiscal domain in rhodopsin assembly and function publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.87.13.4991 contributor: fullname: Doi – volume: 73 start-page: 4145 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB25 article-title: Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5 publication-title: J. Virol. doi: 10.1128/JVI.73.5.4145-4155.1999 contributor: fullname: Olson – volume: 464 start-page: 103 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB35 article-title: Progress toward an explicit mechanistic model for the light-driven pump, bacteriorhodopsin publication-title: FEBS Lett. doi: 10.1016/S0014-5793(99)01685-3 contributor: fullname: Lanyi – volume: 274 start-page: 28745 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB45 article-title: Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.40.28745 contributor: fullname: Mirzabekov – volume: 73 start-page: 1645 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB29 article-title: CCR5-mediated human immunodeficiency virus entry depends on an amino-terminal gp120-binding site and on the conformational integrity of all four extracellular domains publication-title: J. Virol. doi: 10.1128/JVI.73.2.1645-1648.1999 contributor: fullname: Genoud – volume: 117 start-page: 929 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB56 article-title: Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve publication-title: Arch. Ophthalmol. doi: 10.1001/archopht.117.7.929 contributor: fullname: Guy – volume: 85 start-page: 1149 year: 1996 ident: 10.1016/S0969-2126(02)00752-9_BIB5 article-title: A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors publication-title: Cell doi: 10.1016/S0092-8674(00)81314-8 contributor: fullname: Doranz – volume: 381 start-page: 667 year: 1996 ident: 10.1016/S0969-2126(02)00752-9_BIB7 article-title: HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5 publication-title: Nature doi: 10.1038/381667a0 contributor: fullname: Dragic – volume: 35 start-page: 3362 year: 1996 ident: 10.1016/S0969-2126(02)00752-9_BIB2 article-title: Molecular cloning and functional expression of a new human CC-chemokine receptor gene publication-title: Biochemistry doi: 10.1021/bi952950g contributor: fullname: Samson – volume: 95 start-page: 11673 year: 1998 ident: 10.1016/S0969-2126(02)00752-9_BIB39 article-title: Lipid patches in membrane protein oligomers publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.95.20.11673 contributor: fullname: Essen – volume: 72 start-page: 1160 year: 1998 ident: 10.1016/S0969-2126(02)00752-9_BIB27 article-title: A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5 publication-title: J. Virol. doi: 10.1128/JVI.72.2.1160-1164.1998 contributor: fullname: Farzan – volume: 291 start-page: 899 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB43 article-title: Structure of bacteriorhodopsin at 1.55 Å resolution publication-title: J. Mol. Biol. doi: 10.1006/jmbi.1999.3027 contributor: fullname: Luecke – volume: 272 start-page: 872 year: 1996 ident: 10.1016/S0969-2126(02)00752-9_BIB1 article-title: HIV-1 entry cofactor publication-title: Science doi: 10.1126/science.272.5263.872 contributor: fullname: Feng – volume: 269 start-page: 19738 year: 1994 ident: 10.1016/S0969-2126(02)00752-9_BIB52 article-title: Structure and function in rhodopsin. Requirements of a specific structure for the intradiscal domain publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)32083-5 contributor: fullname: Anukanth – volume: 348 start-page: 419 year: 1990 ident: 10.1016/S0969-2126(02)00752-9_BIB66 article-title: Crystal structure of an HIV-binding recombinant fragment of human CD4 publication-title: Nature doi: 10.1038/348419a0 contributor: fullname: Ryu – volume: 274 start-page: 18902 year: 1999 ident: 10.1016/S0969-2126(02)00752-9_BIB33 article-title: Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.27.18902 contributor: fullname: Blanpain |
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| SubjectTerms | Amino Acid Sequence Animals bacteriorhodopsin Bacteriorhodopsins - chemistry Bacteriorhodopsins - genetics Bacteriorhodopsins - metabolism Cattle CCR5 chimera COS Cells G protein-coupled receptor Genes, Reporter HIV-1 HIV-1 - chemistry HIV-1 - metabolism Humans membrane protein folding Molecular Sequence Data Protein Structure, Secondary Receptors, CCR5 - chemistry Receptors, CCR5 - genetics Receptors, CCR5 - metabolism Receptors, HIV - chemistry Receptors, HIV - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Spectrum Analysis |
| Title | Grafting Segments from the Extracellular Surface of CCR5 onto a Bacteriorhodopsin Transmembrane Scaffold Confers HIV-1 Coreceptor Activity |
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