Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome

• Published in: Cell reports (Cambridge) Vol. 35; no. 8; p. 109161
• Main Authors: Qin, Qiang, Shou, Jia’nan, Li, Mengjie, Gu, Meidi, Meng, Zhuoxian, Xu, Pinglong, Meng, Hua, Wang, Xiaojian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.05.2021
• Subjects: adipose tissue macrophages; Animals; Humans; Inflammasomes - genetics; Inflammation - metabolism; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLRP3 inflammasome; Obesity - genetics; obesity-associated metabolic disorder; Protein Serine-Threonine Kinases - therapeutic use; serine\threonine protein kinase 24; Stk24; Stk24; NLRP3 inflammasome; serine\threonine protein kinase 24; adipose tissue macrophages; obesity-associated metabolic disorder

Adipose tissue macrophages (ATMs) regulate the occurrence of obesity and its related diseases. Here, we found that serine/threonine protein kinase 24 (Stk24) expression is downregulated significantly in ATMs in obese subjects or obese subjects with type 2 diabetes and mice fed a high-fat diet (HFD)....