Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidines

• Published in: European journal of medicinal chemistry Vol. 75; pp. 195 - 202
• Main Authors: Kotaiah, Y., Nagaraju, K., Harikrishna, N., Venkata Rao, C., Yamini, L., Vijjulatha, M.
• Format: Journal Article
• Language: English
• Published: ISSY-LES-MOULINEAUX Elsevier Masson SAS 21.03.2014; Elsevier
• Subjects: Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antimicrobial activities; Antioxidant properties; Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - pharmacology; Bacteria - drug effects; Bacterial Infections - drug therapy; Benzene Derivatives - chemical synthesis; Benzene Derivatives - chemistry; Benzene Derivatives - pharmacology; Chemistry, Medicinal; Fungi - drug effects; Humans; Life Sciences & Biomedicine; Microbial Sensitivity Tests; Molecular docking; Molecular Docking Simulation; Mycoses - drug therapy; Organoselenium Compounds - chemical synthesis; Organoselenium Compounds - chemistry; Organoselenium Compounds - pharmacology; Pharmacology & Pharmacy; Pyrimidines - chemical synthesis; Pyrimidines - chemistry; Pyrimidines - pharmacology; Science & Technology; Selenopheno[2,3-d]pyrimidines; Synthesis; Thiadiazoles - chemical synthesis; Thiadiazoles - chemistry; Thiadiazoles - pharmacology; Triazolothiadiazoles; Selenopheno[2,3-d]pyrimidines; Antioxidant properties; Synthesis; Antimicrobial activities; Triazolothiadiazoles; Molecular docking; SCAVENGING PROPERTIES; FACILE SYNTHESIS; PHARMACOLOGICAL-ACTIVITIES; CANCER; SELENIUM

A series of 1,2,4-(triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidines (10a–j) were synthesized with various substituted anilines and benzoic acids. Structures of newly synthesized compounds were established by IR, 1H &13C NMR and LC–MS spectral data. The antioxidant activity of...