Cryptococcus gattii Infection as the Major Clinical Manifestation in Patients with Autoantibodies Against Granulocyte–Macrophage Colony-Stimulating Factor

• Published in: Journal of clinical immunology Vol. 42; no. 8; pp. 1730 - 1741
• Main Authors: Wang, Shang-Yu, Lo, Yu-Fang, Shih, Han-Po, Ho, Mao-Wang, Yeh, Chun-Fu, Peng, Jhan-Jie, Ting, He-Ting, Lin, Kuo-Hsi, Huang, Wen-Chi, Chen, Yi-Chun, Chiu, Yu-Hsin, Hsu, Chien-Wei, Tseng, Yu-Ting, Wang, Lih-Shinn, Lei, Wei-Yi, Lin, Chen-Yuan, Aoh, Yu, Chou, Chia-Huei, Wu, Tsai-Yi, Ding, Jing-Ya, Lo, Chia-Chi, Lin, You-Ning, Tu, Kun-Hua, Lei, Wei-Te, Kuo, Chen-Yen, Chi, Chih-Yu, Ku, Cheng-Lung
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2022; Springer Nature B.V
• Subjects: Alveoli; Autoantibodies; Biomedical and Life Sciences; Biomedicine; blood; Central nervous system; Colonies; Colony-stimulating factor; Cryptococcosis; Cryptococcosis - diagnosis; Cryptococcosis - epidemiology; Cryptococcus gattii; Epidemiology; Fungal infections; Granulocyte-macrophage colony-stimulating factor; Granulocyte-Macrophage Colony-Stimulating Factor - immunology; Granulocytes; health insurance; Histocompatibility antigen HLA; Humans; Immunology; Infectious Diseases; Internal Medicine; Investigations; Medical Microbiology; Medical records; Original Article; pathogenesis; Patients; Pulmonary Alveolar Proteinosis - diagnosis; Pulmonary Alveolar Proteinosis - etiology; Taiwan; Taiwan; Autoantibody; Anti-cytokine; Anti-GM-CSF; Pulmonary alveolar proteinosis; Cryptococcus gattii

Purpose Anti-granulocyte–macrophage colony-stimulating factor autoantibodies (anti-GM-CSF Abs) are a predisposing factor for pulmonary alveolar proteinosis (PAP) and Cryptococcus gattii cryptococcosis. This study aimed to investigate clinical manifestations in anti-GM-CSF Ab-positive patients with C...