Faster Haplotype Frequency Estimation Using Unrelated Subjects

• Published in: Human heredity Vol. 53; no. 1; pp. 36 - 41
• Main Authors: Zhao, Jing Hua, Sham, Pak Chung
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2002
• Subjects: Alcoholism - genetics; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Gene Frequency; Genetic Markers; Haplotypes - genetics; HLA Antigens; Humans; Linkage Disequilibrium; Original Paper; Schizophrenia - genetics; Statistics as Topic - methods; Gene counting; Permutation tests; Case-control association analysis; EM algorithm; Linkage disequilibrium; Contingency table analysis

Linkage disequilibrium (LD) between tightly linked loci provides fine mapping information of disease-predisposing allelic variants. The most common method of LD analysis involves unrelated cases and controls. We have previously proposed model-free and permutation tests for diseases with unknown mode...