Oligodendrocyte degeneration and concomitant microglia activation directs peripheral immune cells into the forebrain

• Published in: Neurochemistry international Vol. 126; pp. 139 - 153
• Main Authors: Chrzanowski, Uta, Bhattarai, Sudip, Scheld, Miriam, Clarner, Tim, Fallier-Becker, Petra, Beyer, Cordian, Rohr, Sven Olaf, Schmitz, Christoph, Hochstrasser, Tanja, Schweiger, Felix, Amor, Sandra, Horn-Bochtler, Anja, Denecke, Bernd, Nyamoya, Stella, Kipp, Markus
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2019
• Subjects: Animals; Cuprizone; Cuprizone - toxicity; Encephalomyelitis, Autoimmune, Experimental - chemically induced; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - pathology; Experimental autoimmune encephalomyelitis; Female; Immunity, Cellular - drug effects; Immunity, Cellular - physiology; Male; Mice; Mice, Inbred C57BL; Microglia - drug effects; Microglia - immunology; Microglia - pathology; Moesin; Multiple sclerosis; Multiple Sclerosis - chemically induced; Multiple Sclerosis - immunology; Multiple Sclerosis - pathology; Myelin-Oligodendrocyte Glycoprotein - toxicity; Oligodendroglia - drug effects; Oligodendroglia - immunology; Oligodendroglia - pathology; Peptide Fragments - toxicity; Prosencephalon - drug effects; Prosencephalon - immunology; Prosencephalon - pathology; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Cuprizone; Moesin

Brain-intrinsic degenerative cascades are a proposed factor driving inflammatory lesion formation in multiple sclerosis (MS) patients. We recently showed that encephalitogenic lymphocytes are recruited to the sites of active demyelination induced by cuprizone. Here, we investigated whether cuprizone...