Emicizumab, a bispecific antibody recognizing coagulation factors IX and X: how does it actually compare to factor VIII? - Lenting, Peter J.; Denis, Cécile V.; Christophe, Olivier D. (Blood, 2017)
Keywords: Animals; Antibodies, Bispecific - chemistry; Antibodies, Bispecific - metabolism; Antibodies, Bispecific - pharmacology; Antibodies, Bispecific - therapeutic use; Antibodies, Monoclonal, Humanized - chemistry; Antibodies, Monoclonal, Humanized - metabolism; Antibodies, Monoclonal, Humanized - pharmacology; Antibodies, Monoclonal, Humanized - therapeutic use; Blood Coagulation - drug effects; Drug Discovery; Enzyme Activation; Factor IX - chemistry; Factor IX - metabolism; Factor VIII - chemistry; Factor VIII - metabolism; Factor VIII - pharmacology; Factor VIII - therapeutic use; Factor X - chemistry; Factor X - metabolism; Factor XIIIa - metabolism; Hemophilia A - blood; Hemophilia A - drug therapy; Humans; Multiprotein Complexes - metabolism; Protein Binding; Substrate Specificity