A Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in Healthy Adult Subjects

• Published in: Drug design, development and therapy Vol. 19; pp. 97 - 110
• Main Authors: Lee, Hae Won, Kang, Woo Youl, Park, Ji Seo, Lee, Jae Hwa, Park, Jin Ju, Gwon, Mi-Ri, Yoon, Young-Ran, Seong, Sook Jin
• Format: Journal Article
• Language: English
• Published: New Zealand Dove 01.01.2025; Dove Medical Press
• Subjects: Administration, Oral; Adult; Cross-Over Studies; Delayed-Action Preparations - administration & dosage; Delayed-Action Preparations - pharmacokinetics; dual delayed-release formulation; esomeprazole; Esomeprazole - administration & dosage; Esomeprazole - pharmacokinetics; Esomeprazole - pharmacology; Female; Gastric Acid - metabolism; Healthy Volunteers; Humans; Male; Middle Aged; Original Research; pharmacodynamics; pharmacokinetics; Proton Pump Inhibitors - administration & dosage; Proton Pump Inhibitors - pharmacokinetics; Proton Pump Inhibitors - pharmacology; Young Adult; pharmacokinetics; esomeprazole; dual delayed-release formulation; pharmacodynamics

YYD601 is a new dual delayed-release formulation of esomeprazole, developed to enhance plasma exposure and prolong the duration of acid suppression. This study aimed to evaluate the safety, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of YYD601 20 mg following single and multiple oral adm...