Cartilage biomechanics: A key factor for osteoarthritis regenerative medicine

Osteoarthritis (OA) is a joint disorder that is highly extended in the global population. Several researches and therapeutic strategies have been probed on OA but without satisfactory long-term results in joint replacement. Recent evidences show how the cartilage biomechanics plays a crucial role in...

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Published inBiochimica et biophysica acta. Molecular basis of disease Vol. 1865; no. 6; pp. 1067 - 1075
Main Authors Martínez-Moreno, D., Jiménez, G., Gálvez-Martín, P., Rus, G., Marchal, J.A.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2019
Subjects
Biomechanical Phenomena - physiology
Biomechanics
Cartilage, Articular - cytology
Cartilage, Articular - physiology
Chondrocytes - cytology
Extracellular Matrix - metabolism
Extracellular Matrix - physiology
Humans
Mechanotransduction
Models, Biological
Osteoarthritis
Osteoarthritis - physiopathology
Regenerative medicine
Regenerative Medicine - methods
Regenerative Medicine - trends
Tissue engineering
Tissue Engineering - methods
Tissue Engineering - trends
Ultrasound
Biomechanics
Mechanotransduction
Tissue engineering
Regenerative medicine
Osteoarthritis
Ultrasound
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Abstract Osteoarthritis (OA) is a joint disorder that is highly extended in the global population. Several researches and therapeutic strategies have been probed on OA but without satisfactory long-term results in joint replacement. Recent evidences show how the cartilage biomechanics plays a crucial role in tissue development. This review describes how physics alters cartilage and its extracellular matrix (ECM); and its role in OA development. The ECM of the articular cartilage (AC) is widely involved in cartilage turnover processes being crucial in regeneration and joint diseases. We also review the importance of physicochemical pathways following the external forces in AC. Moreover, new techniques probed in cartilage tissue engineering for biomechanical stimulation are reviewed. The final objective of these novel approaches is to create a cellular implant that maintains all the biochemical and biomechanical properties of the original tissue for long-term replacements in patients with OA. •Biomechanics plays a crucial role in healthy articular cartilage (AC).•Osteoarthritis (OA) is preceded by mechanical and biochemical derangements of AC.•Biomechanical stimuli are necessaries for tissue engineering of OA.•Biomechanics is essential for building medical devices useful in OA treatment.
AbstractList Osteoarthritis (OA) is a joint disorder that is highly extended in the global population. Several researches and therapeutic strategies have been probed on OA but without satisfactory long-term results in joint replacement. Recent evidences show how the cartilage biomechanics plays a crucial role in tissue development. This review describes how physics alters cartilage and its extracellular matrix (ECM); and its role in OA development. The ECM of the articular cartilage (AC) is widely involved in cartilage turnover processes being crucial in regeneration and joint diseases. We also review the importance of physicochemical pathways following the external forces in AC. Moreover, new techniques probed in cartilage tissue engineering for biomechanical stimulation are reviewed. The final objective of these novel approaches is to create a cellular implant that maintains all the biochemical and biomechanical properties of the original tissue for long-term replacements in patients with OA. •Biomechanics plays a crucial role in healthy articular cartilage (AC).•Osteoarthritis (OA) is preceded by mechanical and biochemical derangements of AC.•Biomechanical stimuli are necessaries for tissue engineering of OA.•Biomechanics is essential for building medical devices useful in OA treatment.
Osteoarthritis (OA) is a joint disorder that is highly extended in the global population. Several researches and therapeutic strategies have been probed on OA but without satisfactory long-term results in joint replacement. Recent evidences show how the cartilage biomechanics plays a crucial role in tissue development. This review describes how physics alters cartilage and its extracellular matrix (ECM); and its role in OA development. The ECM of the articular cartilage (AC) is widely involved in cartilage turnover processes being crucial in regeneration and joint diseases. We also review the importance of physicochemical pathways following the external forces in AC. Moreover, new techniques probed in cartilage tissue engineering for biomechanical stimulation are reviewed. The final objective of these novel approaches is to create a cellular implant that maintains all the biochemical and biomechanical properties of the original tissue for long-term replacements in patients with OA.
Author Jiménez, G.
Marchal, J.A.
Gálvez-Martín, P.
Rus, G.
Martínez-Moreno, D.
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Keywords Biomechanics
Mechanotransduction
Tissue engineering
Regenerative medicine
Osteoarthritis
Ultrasound
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SecondaryResourceType review_article
Snippet Osteoarthritis (OA) is a joint disorder that is highly extended in the global population. Several researches and therapeutic strategies have been probed on OA...
SourceID proquest
crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 1067
SubjectTerms Biomechanical Phenomena - physiology
Biomechanics
Cartilage, Articular - cytology
Cartilage, Articular - physiology
Chondrocytes - cytology
Extracellular Matrix - metabolism
Extracellular Matrix - physiology
Humans
Mechanotransduction
Models, Biological
Osteoarthritis
Osteoarthritis - physiopathology
Regenerative medicine
Regenerative Medicine - methods
Regenerative Medicine - trends
Tissue engineering
Tissue Engineering - methods
Tissue Engineering - trends
Ultrasound
Title Cartilage biomechanics: A key factor for osteoarthritis regenerative medicine
URI https://dx.doi.org/10.1016/j.bbadis.2019.03.011
https://www.ncbi.nlm.nih.gov/pubmed/30910703
https://search.proquest.com/docview/2197896602
Volume 1865
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