Challenges and opportunities in the discovery, development, and commercialization of pathogen-targeted antibiotics

• Published in: Drug discovery today Vol. 26; no. 9; pp. 2084 - 2089
• Main Authors: Altarac, David, Gutch, Michael, Mueller, John, Ronsheim, Matthew, Tommasi, Ruben, Perros, Manos
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2021
• Subjects: Animals; Anti-Bacterial Agents - therapeutic use; Antimicrobial Stewardship; Bacteria - drug effects; Bacterial Infections - drug therapy; Biomedical Research; Drug Development; Drug Discovery; Humans; Technology Transfer

•Antimicrobial resistance is a direct result of antibiotic use.•Indiscriminate and excessive use of broad-spectrum antibiotics exacerbates the problem.•Rationally designed antibiotics can be optimized to target MDR pathogens.•Pathogen-targeted antibiotics enable streamlined development and regulator...