Impact of red blood cell transfusion on platelet activation and aggregation in healthy volunteers: results of the TRANSFUSION study

• Published in: European heart journal Vol. 31; no. 22; pp. 2816 - 2821
• Main Authors: Silvain, Johanne, Pena, Ana, Cayla, Guillaume, Brieger, David, Bellemain-Appaix, Anne, Chastre, Thomas, Vignalou, Jean-Baptiste, Beygui, Farzin, Barthelemy, Olivier, Collet, Jean-Philippe, Montalescot, Gilles
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.11.2010
• Subjects: ACS; Adult; Biological and medical sciences; Cardiology. Vascular system; Cell Adhesion Molecules - metabolism; Clopidogrel; Erythrocyte Transfusion; Female; Flow Cytometry; Hematocrit - methods; Hemoglobins - metabolism; Humans; Male; Medical sciences; Microfilament Proteins - metabolism; P-Selectin - metabolism; Phosphoproteins - metabolism; Phosphorylation - physiology; Platelet Activation - drug effects; Platelet Activation - physiology; Platelet Aggregation - drug effects; Platelet Aggregation - physiology; Platelet Aggregation Inhibitors - pharmacology; Platelet response; Transfusion; Human; Transfusion; Healthy subject; Red blood cell; Activation; Antiplatelet agent; Result; Response; ACS; Platelet; Platelet response; Clopidogrel; Circulatory system; Cardiology

Aims The underlying mechanisms leading to recurrent ischaemic events or mortality after red blood cell (RBC) transfusion in anaemic acute coronary syndrome patients are poorly understood. The aim of this paper is to determine whether RBC transfusion increases platelet activation and aggregation. Met...