Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

• Published in: Science translational medicine Vol. 9; no. 392
• Main Authors: Shi, Qiaoqiao, Chowdhury, Saba, Ma, Rong, Le, Kevin X, Hong, Soyon, Caldarone, Barbara J, Stevens, Beth, Lemere, Cynthia A
• Format: Journal Article
• Language: English
• Published: United States 31.05.2017
• Subjects: Aging - pathology; Amyloid beta-Protein Precursor - metabolism; Animals; Astrocytes - pathology; Cognitive Dysfunction; Complement C3 - deficiency; Cytokines - metabolism; Gliosis - pathology; Hippocampus - metabolism; Hippocampus - pathology; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration - pathology; Nerve Degeneration - prevention & control; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Presenilin-1 - metabolism; Solubility; Synapses - metabolism; Synapses - pathology

The complement cascade not only is an innate immune response that enables removal of pathogens but also plays an important role in microglia-mediated synaptic refinement during brain development. Complement C3 is elevated in Alzheimer's disease (AD), colocalizing with neuritic plaques, and appe...