Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice - Shi, Qiaoqiao; Chowdhury, Saba; Ma, Rong; Le, Kevin X; Hong, Soyon; Caldarone, Barbara J; Stevens, Beth; Lemere, Cynthia A (Science translational medicine, 2017)
Keywords: Aging - pathology; Amyloid beta-Protein Precursor - metabolism; Animals; Astrocytes - pathology; Cognitive Dysfunction; Complement C3 - deficiency; Cytokines - metabolism; Gliosis - pathology; Hippocampus - metabolism; Hippocampus - pathology; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration - pathology; Nerve Degeneration - prevention & control; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Presenilin-1 - metabolism; Solubility; Synapses - metabolism; Synapses - pathology