The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia

• Published in: Blood Vol. 129; no. 9; pp. 1124 - 1133
• Main Authors: Sanchez-Martin, Marta, Ferrando, Adolfo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.03.2017
• Subjects: Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Humans; Mutation; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Receptor, Notch1 - genetics; Receptor, Notch1 - metabolism

T-cell acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy that results from the transformation of immature T-cell progenitors. Aberrant cell growth and proliferation in T-ALL lymphoblasts are sustained by activation of strong oncogenic drivers promoting cell anabol...