An ultrasensitive GSH-specific fluorescent probe unveils celastrol-induced ccRCC ferroptosis
[Display omitted] •GSH-specific fluorescent probe for GSH detection in clinical samples and live cell and tumor imaging.•Celastrol induces ferroptosis in ccRCC.•GSH-specific fluorescent probe tracks celastrol-induced ccRCC ferroptosis. Glutathione (GSH) is closely related to the occurrence and devel...
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Published in | Bioorganic chemistry Vol. 134; p. 106454 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
SAN DIEGO
Elsevier Inc
01.05.2023
Elsevier |
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Abstract | [Display omitted]
•GSH-specific fluorescent probe for GSH detection in clinical samples and live cell and tumor imaging.•Celastrol induces ferroptosis in ccRCC.•GSH-specific fluorescent probe tracks celastrol-induced ccRCC ferroptosis.
Glutathione (GSH) is closely related to the occurrence and development of tumors. The intracellular GSH levels are abnormally altered when tumor cells undergo programmed cell death. Therefore, real-time monitoring of the dynamic changes of intracellular GSH levels can better enable the early diagnosis of diseases and evaluate the effects of cell death-inducing drugs. In this study, a stable and highly selective fluorescent probe AR has been designed and synthesized for the fluorescence imaging and rapid detection of GSH in vitro and in vivo, as well as patient-derived tumor tissue. More importantly, the AR probe can be used to track changes in GSH levels and fluorescence imaging during the treatment of clear cell renal cell carcinoma (ccRCC) with celastrol (CeT) via inducing ferroptosis. These findings demonstrate that the developed fluorescent probe AR exhibits high selectivity and sensitivity, as well as good biocompatibility and long-term stability, which can be used to image endogenous GSH in living tumors and cells. Also, a significant decrease in GSH levels was observed by the fluorescent probe AR during the treatment of ccRCC with CeT-induced ferroptosis in vitro and in vivo. Overall, these findings will provide a novel strategy for celastrol targeting ferroptosis in the treatment of ccRCC and the application of fluorescent probes to help reveal the underlying mechanism of CeT in the treatment of ccRCC. |
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AbstractList | [Display omitted]
•GSH-specific fluorescent probe for GSH detection in clinical samples and live cell and tumor imaging.•Celastrol induces ferroptosis in ccRCC.•GSH-specific fluorescent probe tracks celastrol-induced ccRCC ferroptosis.
Glutathione (GSH) is closely related to the occurrence and development of tumors. The intracellular GSH levels are abnormally altered when tumor cells undergo programmed cell death. Therefore, real-time monitoring of the dynamic changes of intracellular GSH levels can better enable the early diagnosis of diseases and evaluate the effects of cell death-inducing drugs. In this study, a stable and highly selective fluorescent probe AR has been designed and synthesized for the fluorescence imaging and rapid detection of GSH in vitro and in vivo, as well as patient-derived tumor tissue. More importantly, the AR probe can be used to track changes in GSH levels and fluorescence imaging during the treatment of clear cell renal cell carcinoma (ccRCC) with celastrol (CeT) via inducing ferroptosis. These findings demonstrate that the developed fluorescent probe AR exhibits high selectivity and sensitivity, as well as good biocompatibility and long-term stability, which can be used to image endogenous GSH in living tumors and cells. Also, a significant decrease in GSH levels was observed by the fluorescent probe AR during the treatment of ccRCC with CeT-induced ferroptosis in vitro and in vivo. Overall, these findings will provide a novel strategy for celastrol targeting ferroptosis in the treatment of ccRCC and the application of fluorescent probes to help reveal the underlying mechanism of CeT in the treatment of ccRCC. Glutathione (GSH) is closely related to the occurrence and development of tumors. The intracellular GSH levels are abnormally altered when tumor cells undergo programmed cell death. Therefore, real-time monitoring of the dynamic changes of intracellular GSH levels can better enable the early diagnosis of diseases and evaluate the effects of cell death-inducing drugs. In this study, a stable and highly selective fluorescent probe AR has been designed and synthesized for the fluorescence imaging and rapid detection of GSH in vitro and in vivo, as well as patient-derived tumor tissue. More importantly, the AR probe can be used to track changes in GSH levels and fluorescence imaging during the treatment of clear cell renal cell carcinoma (ccRCC) with celastrol (CeT) via inducing ferroptosis. These findings demonstrate that the developed fluorescent probe AR exhibits high selectivity and sensitivity, as well as good biocompatibility and long-term stability, which can be used to image endogenous GSH in living tumors and cells. Also, a significant decrease in GSH levels was observed by the fluorescent probe AR during the treatment of ccRCC with CeT-induced ferroptosis in vitro and in vivo. Overall, these findings will provide a novel strategy for celastrol targeting ferroptosis in the treatment of ccRCC and the application of fluorescent probes to help reveal the underlying mechanism of CeT in the treatment of ccRCC. Glutathione (GSH) is closely related to the occurrence and development of tumors. The intracellular GSH levels are abnormally altered when tumor cells undergo programmed cell death. Therefore, real-time monitoring of the dynamic changes of intracellular GSH levels can better enable the early diagnosis of diseases and evaluate the effects of cell death-inducing drugs. In this study, a stable and highly selective fluorescent probe AR has been designed and synthesized for the fluorescence imaging and rapid detection of GSH in vitro and in vivo, as well as patient-derived tumor tissue. More importantly, the AR probe can be used to track changes in GSH levels and fluorescence imaging during the treatment of clear cell renal cell carcinoma (ccRCC) with celastrol (CeT) via inducing ferroptosis. These findings demonstrate that the developed fluorescent probe AR exhibits high selec-tivity and sensitivity, as well as good biocompatibility and long-term stability, which can be used to image endogenous GSH in living tumors and cells. Also, a significant decrease in GSH levels was observed by the fluorescent probe AR during the treatment of ccRCC with CeT-induced ferroptosis in vitro and in vivo. Overall, these findings will provide a novel strategy for celastrol targeting ferroptosis in the treatment of ccRCC and the application of fluorescent probes to help reveal the underlying mechanism of CeT in the treatment of ccRCC. |
ArticleNumber | 106454 |
Author | Zeng, Qing Deng, Changfeng Zhu, Neng Li, Hongfang Zhang, Chanjuan Qin, Li |
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Cites_doi | 10.1021/jacs.7b12545 10.1038/s41388-018-0315-z 10.1039/c5sc03817k 10.1016/j.cell.2015.05.011 10.1111/nph.15809 10.1039/c7sc02888a 10.3390/nu10060760 10.1073/pnas.1907122116 10.1002/elan.200704086 10.1016/j.cmet.2019.01.020 10.1194/jlr.C066712 10.1021/acssensors.9b02118 10.1080/15548627.2019.1687985 10.1016/j.aca.2010.01.009 10.1111/j.1365-2362.2009.02186.x 10.1016/j.apsb.2021.12.007 10.1039/c5sc02431e 10.1126/sciadv.aba8968 10.1126/sciadv.aat0351 10.1016/j.redox.2019.101410 10.1016/j.cell.2019.10.007 10.1016/j.bios.2010.05.005 10.1039/d0cs00718h 10.1021/acs.jproteome.8b00797 10.3389/fonc.2019.00002 10.3892/ijmm.2020.4770 10.1039/c5cc02788h 10.1126/sciadv.aay6350 10.1038/s41401-020-00572-6 10.2147/OTT.S250066 10.1038/s41467-020-16423-1 10.3892/ijo.2018.4648 10.1038/s41467-020-15730-x 10.1021/jacs.0c10840 10.3390/s120505940 10.1038/s41556-019-0356-8 10.3389/fphar.2021.658092 10.1016/j.cmet.2020.03.004 10.7150/thno.22252 10.1016/j.neuron.2019.04.017 10.1021/ja401360a 10.1039/C7SC02888A 10.1039/C5SC02431E 10.1126/sciadv.abc3687 10.1039/C5SC03817K 10.1016/S0003-2670(99)00610-8 10.1039/C5CC02788H 10.1039/D0CS00718H |
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Keywords | Ferroptosis Fluorescence probe Clear cell renal cell carcinoma Celastrol Glutathione METABOLISM DIRECT ELECTRON-TRANSFER |
Language | English |
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References | Wang, Chen, Lou, Kim, Fujitsuka, Yu, Majima (b0150) 2019; 116 Zhang, Liu, Liu, Li, Wang, Yao, Xu, Sun (b0165) 2016; 7 Jiang, Zhao, Huang, Li, Upputuri, Sun, Han, Pramanik, Miao, Duan, Pu, Zhang (b0215) 2020; 11 Lan, Wang, He, Ma, Bin, Chi, Chen, Cai (b0155) 2018; 10 Liu, Lee, Salazar Hernandez, Mazitschek, Ozcan (b0205) 2015; 161 Ma, Xie, Luo, Yin, Li, Wang, Xiong, Zhang, Jiang, Qi, Zhou, Yang, Wang, Ma, Gao, Yang (b0100) 2019; 54 Luo, Liu, Zhang, Yang, Wong, Xia, Zhang, Chen, Tian, Yang, Dai, Shen, Wang (b0130) 2022; 12 Kim, Shin, Kim, Lee, Jun, Park, Kim (b0195) 2009; 39 Wang, Ahn, Asmis (b0015) 2020; 31 Yan, Huo, Yue, Chao, Yin (b0170) 2021; 143 Zhang, Li, Dong, Meng, Zhi, Yuan, Yao (b0075) 2020; 13 Zhang, Zhao, Xiao, Yang, Hu, Zhu, Gonzalez, Li (b0115) 2019; 18 Panikkanvalappil, Hira, El-Sayed (b0180) 2016; 7 Yu, Li, Wang, Han (b0060) 2013; 135 Guo, Yang, Hakuna, Barve, Escobedo, Lowry, Strongin (b0135) 2012; 12 Gao, Li, Li, Zhou, Ma (b0140) 2015; 51 Savchenko, Cherkas, Liu, Braun, Kleschevnikov, Miller, Molokanova (b0160) 2018; 4 Afonso, Machado, Lavrador, Quintao, Moore, Lottenberg (b0085) 2018; 10 Zhang, Guo, Li, Shen, Kong, Shao, Ding, Tan, Chen, Zhang, Zheng (b0090) 2020; 16 Zou, Li, Xing, Duan, Zhou, Yu (b0055) 2020; 5 Madison (b0105) 2016; 57 Li, Li, Liu, Wu, Wu, Wang, Ye, Jia, Wang, Li, Zhu, Ding, Lai, Wang, Dick, Lu (b0145) 2020; 6 He, Liao, Song, Li, Liu, Xiong, Song, Yang (b0220) 2021; 47 Zhao, Meng, Shao, Wan, Jiao (b0045) 2008; 20 Lee, Kim, Han, Fan, Guo, Aziz, Nowsheen, Kim, Park, Luo, Chung, Choi, Aziz, Yin, Tong, Fiesel, Springer, Zhang, Lou (b0185) 2019; 21 Han, Song, Yu, Chen (b0175) 2017; 8 Zhang, Zhu, Wang, Liu, Zhao, Wu, Liao, Qin (b0120) 2021; 12 Xiong, Xiao, Li, Yang (b0070) 2021; 50 D.J. Clark, S.M. Dhanasekaran, F. Petralia, J. Pan, X. Song, Y. Hu, F. da Veiga Leprevost, B. Reva, T.M. Lih, H.Y. Chang, W. Ma, C. Huang, C.J. Ricketts, L. Chen, A. Krek, Y. Li, D. Rykunov, Q.K. Li, L.S. Chen, U. Ozbek, S. Vasaikar, Y. Wu, S. Yoo, S. Chowdhury, M.A. Wyczalkowski, J. Ji, M. Schnaubelt, A. Kong, S. Sethuraman, D.M. Avtonomov, M. Ao, A. Colaprico, S. Cao, K.C. Cho, S. Kalayci, S. Ma, W. Liu, K. Ruggles, A. Calinawan, Z.H. Gümüş, D. Geiszler, E. Kawaler, G.C. Teo, B. Wen, Y. Zhang, S. Keegan, K. Li, F. Chen, N. Edwards, P.M. Pierorazio, X.S. Chen, C.P. Pavlovich, A.A. Hakimi, G. Brominski, J.J. Hsieh, A. Antczak, T. Omelchenko, J. Lubinski, M. Wiznerowicz, W.M. Linehan, C.R. Kinsinger, M. Thiagarajan, E.S. Boja, M. Mesri, T. Hiltke, A.I. Robles, H. Rodriguez, J. Qian, D. Fenyö, B. Zhang, L. Ding, E. Schadt, A.M. Chinnaiyan, Z. Zhang, G.S. Omenn, M. Cieslik, D.W. Chan, A.I. Nesvizhskii, P. Wang, H. Zhang, Integrated proteogenomic characterization of clear cell renal cell carcinoma, Cell 179(4) (2019) 964–983.e31. Jacobs, Peairs, Venton (b0035) 2010; 662 Zhou, Hu, Gao, Su, Zhang, Zhao, Chen, Tu, Song, Wang, Huang, Gao (b0200) 2019; 223 Zhang, Zhu, Long, Wu, Wang, Liu, Liao, Qin (b0125) 2021; 42 Kaušaitė, Ramanavičienė, Ramanavičius (b0025) 2008; 19 Miess, Dankworth, Gouw, Rosenfeldt, Schmitz, Jiang, Saunders, Howell, Downward, Felsher, Peck, Schulze (b0080) 2018; 37 Verma, Vinik, Saroha, Nair, Ruppin, Mills, Karn, Dubey, Khera, Raj, Maina, Lev (b0210) 2020; 6 Long, Huang, Wang, Wu, Wang, Gong, Zhang, Sessler (b0050) 2018; 140 Harris, Endress, Coloff, Selfors, McBrayer, Rosenbluth, Takahashi, Dhakal, Koduri, Oser, Schauer, Doherty, Hong, Kang, Younger, Doench, Hahn, Buhrlage, DeNicola, Kaelin, Brugge (b0005) 2019; 29 Li, Kwon, Chung, Lim, Lee, Yue, Yoon, Kim, Nam, Chung, Kim, Yin, Ryu, Yoon (b0020) 2018; 8 Balsa, Perry, Bennett, Jedrychowski, Gygi, Doench, Puigserver (b0190) 2020; 11 Xu, Zhao, Chen, Ye, Nan, Zhou, Jiang, Yang, Huang, Yuan, Xing, Wei, Li, Shi, Yan (b0110) 2019; 9 Oztekin, Krikstolaityte, Ramanaviciene, Yazicigil, Ramanavicius (b0040) 2010; 26 Gorton, Lindgren, Larsson, Munteanu, Ruzgas, Gazaryan (b0030) 1999; 400 Smith, Lin, Sheehan, Van der Goes, van Naters, Neukomm, Graves, Bis-Brewer, Züchner (b0065) 2019; 103 Kurniawan, Franchina, Guerra, Bonetti, Baguet, Grusdat, Schlicker, Hunewald, Dostert, Merz, Binsfeld, Duncan, Farinelle, Nonnenmacher, Haight, Das Gupta, Ewen, Taskesen, Halder, Chen, Jäger, Ollert, Wilmes, Vasiliou, Harris, Knobbe-Thomsen, Turner, Mak, Lohoff, Meiser, Hiller, Brenner (b0010) 2020; 31 Clark, DJ (WOS:000493898000014) 2019; 179 Ma, CQ (WOS:000454923900015) 2019; 54 Zhao, CZ (WOS:000254144500009) 2008; 20 Kim, DH (WOS:000268298100011) 2009; 39 Afonso, MS (WOS:000436507200104) 2018; 10 Zhang, CJ (WOS:000645613000001) 2021; 12 Gao, XH (WOS:000354997400037) 2015; 51 Gorton, L (WOS:000084204200010) 1999; 400 Luo, P (WOS:000810964300001) 2022; 12 Guo, YX (WOS:000304539200044) 2012; 12 Liu, JL (WOS:000355152600009) 2015; 161 Smith, GA (WOS:000473726400007) 2019; 103 Zhang, CJ (WOS:000597991300004) 2021; 42 Kausait, A. (000953383600001.5) 2008; 19 Lan, D (WOS:000433360300004) 2018; 10 Savchenko, A (WOS:000432440600051) 2018; 4 Zhang, T (WOS:000460491800029) 2019; 18 Zhou, JW (WOS:000472678700023) 2019; 223 Jiang, YY (WOS:000558826300002) 2020; 11 Xiong, YX (WOS:000632993700001) 2021; 50 Miess, H (WOS:000446312900005) 2018; 37 Kurniawan, H (WOS:000544625500009) 2020; 31 Li, J (WOS:000424515900017) 2018; 8 Long, LL (WOS:000424851500041) 2018; 140 Zou, YX (WOS:000510079300032) 2020; 5 Xu, LN (WOS:000456919400001) 2019; 9 Jacobs, CB (WOS:000275340600001) 2010; 662 Yan, HM (WOS:000611083700041) 2021; 143 Zhang, ZL (WOS:000495818500001) 2020; 16 Oztekin, Y (WOS:000282560500042) 2010; 26 Wang, LX (WOS:000533802200001) 2020; 31 Balsa, E (WOS:000542983000006) 2020; 11 Harris, IS (WOS:000467054100016) 2019; 29 Lee, SB (WOS:000478029000007) 2019; 21 Han, XY (WOS:000411730500032) 2017; 8 Wang, WK (WOS:000486388400019) 2019; 116 Verma, N (WOS:000561426700017) 2020; 6 Zhang, YQ (WOS:000539166200001) 2020; 13 Panikkanvalappil, SR (WOS:000368835300038) 2016; 7 He, ZQ (WOS:000601400100024) 2021; 47 Madison, BB (WOS:000371095500001) 2016; 57 Yu, FB (WOS:000319551000041) 2013; 135 Li, YX (WOS:000507552400026) 2020; 6 Zhang, HT (WOS:000366826900028) 2016; 7 Zhang (10.1016/j.bioorg.2023.106454_b0120) 2021; 12 Harris (10.1016/j.bioorg.2023.106454_b0005) 2019; 29 Li (10.1016/j.bioorg.2023.106454_b0020) 2018; 8 Jacobs (10.1016/j.bioorg.2023.106454_b0035) 2010; 662 Luo (10.1016/j.bioorg.2023.106454_b0130) 2022; 12 Zhou (10.1016/j.bioorg.2023.106454_b0200) 2019; 223 Jiang (10.1016/j.bioorg.2023.106454_b0215) 2020; 11 Verma (10.1016/j.bioorg.2023.106454_b0210) 2020; 6 Long (10.1016/j.bioorg.2023.106454_b0050) 2018; 140 Lan (10.1016/j.bioorg.2023.106454_b0155) 2018; 10 Zhang (10.1016/j.bioorg.2023.106454_b0075) 2020; 13 Wang (10.1016/j.bioorg.2023.106454_b0015) 2020; 31 Xiong (10.1016/j.bioorg.2023.106454_b0070) 2021; 50 Kaušaitė (10.1016/j.bioorg.2023.106454_b0025) 2008; 19 Smith (10.1016/j.bioorg.2023.106454_b0065) 2019; 103 Zhang (10.1016/j.bioorg.2023.106454_b0115) 2019; 18 Li (10.1016/j.bioorg.2023.106454_b0145) 2020; 6 Zhao (10.1016/j.bioorg.2023.106454_b0045) 2008; 20 10.1016/j.bioorg.2023.106454_b0095 Lee (10.1016/j.bioorg.2023.106454_b0185) 2019; 21 Panikkanvalappil (10.1016/j.bioorg.2023.106454_b0180) 2016; 7 Afonso (10.1016/j.bioorg.2023.106454_b0085) 2018; 10 Zhang (10.1016/j.bioorg.2023.106454_b0165) 2016; 7 Balsa (10.1016/j.bioorg.2023.106454_b0190) 2020; 11 Miess (10.1016/j.bioorg.2023.106454_b0080) 2018; 37 Xu (10.1016/j.bioorg.2023.106454_b0110) 2019; 9 Zhang (10.1016/j.bioorg.2023.106454_b0125) 2021; 42 Han (10.1016/j.bioorg.2023.106454_b0175) 2017; 8 Yan (10.1016/j.bioorg.2023.106454_b0170) 2021; 143 Liu (10.1016/j.bioorg.2023.106454_b0205) 2015; 161 Wang (10.1016/j.bioorg.2023.106454_b0150) 2019; 116 He (10.1016/j.bioorg.2023.106454_b0220) 2021; 47 Oztekin (10.1016/j.bioorg.2023.106454_b0040) 2010; 26 Savchenko (10.1016/j.bioorg.2023.106454_b0160) 2018; 4 Zou (10.1016/j.bioorg.2023.106454_b0055) 2020; 5 Ma (10.1016/j.bioorg.2023.106454_b0100) 2019; 54 Madison (10.1016/j.bioorg.2023.106454_b0105) 2016; 57 Zhang (10.1016/j.bioorg.2023.106454_b0090) 2020; 16 Gorton (10.1016/j.bioorg.2023.106454_b0030) 1999; 400 Yu (10.1016/j.bioorg.2023.106454_b0060) 2013; 135 Gao (10.1016/j.bioorg.2023.106454_b0140) 2015; 51 Kim (10.1016/j.bioorg.2023.106454_b0195) 2009; 39 Kurniawan (10.1016/j.bioorg.2023.106454_b0010) 2020; 31 Guo (10.1016/j.bioorg.2023.106454_b0135) 2012; 12 |
References_xml | – volume: 39 start-page: 819 year: 2009 end-page: 827 ident: b0195 article-title: Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated from publication-title: Eur. J. Clin. Invest. contributor: fullname: Kim – volume: 31 year: 2020 ident: b0015 article-title: Sexual dimorphism in glutathione metabolism and glutathione-dependent responses publication-title: Redox Biol. contributor: fullname: Asmis – volume: 4 start-page: eaat0351 year: 2018 ident: b0160 article-title: Graphene biointerfaces for optical stimulation of cells publication-title: Sci. Adv. contributor: fullname: Molokanova – volume: 140 start-page: 1870 year: 2018 end-page: 1875 ident: b0050 article-title: A Mitochondria-specific fluorescent probe for visualizing endogenous hydrogen cyanide fluctuations in neurons publication-title: J. Am. Chem. Soc. contributor: fullname: Sessler – volume: 11 start-page: 1857 year: 2020 ident: b0215 article-title: Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy publication-title: Nat. Commun. contributor: fullname: Zhang – volume: 57 start-page: 333 year: 2016 end-page: 335 ident: b0105 article-title: Srebp2: a master regulator of sterol and fatty acid synthesis publication-title: J. Lipid Res. contributor: fullname: Madison – volume: 13 start-page: 5443 year: 2020 end-page: 5453 ident: b0075 article-title: PSAT1 regulated oxidation-reduction balance affects the growth and prognosis of epithelial ovarian cancer publication-title: Onco Targets Ther contributor: fullname: Yao – volume: 51 start-page: 9388 year: 2015 end-page: 9390 ident: b0140 article-title: A simple fluorescent off-on probe for the discrimination of cysteine from glutathione publication-title: Chem. Commun. (Camb.) contributor: fullname: Ma – volume: 10 start-page: 1295 year: 2018 end-page: 1309 ident: b0155 article-title: Exogenous glutathione contributes to cisplatin resistance in lung cancer A549 cells publication-title: Am. J. Transl. Res. contributor: fullname: Cai – volume: 26 start-page: 267 year: 2010 end-page: 270 ident: b0040 article-title: 1, 10-Phenanthroline derivatives as mediators for glucose oxidase publication-title: Biosens. Bioelectron. contributor: fullname: Ramanavicius – volume: 21 start-page: 940 year: 2019 end-page: 951 ident: b0185 article-title: The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome publication-title: Nat. Cell Biol. contributor: fullname: Lou – volume: 31 start-page: 920 year: 2020 end-page: 936.e7 ident: b0010 article-title: Glutathione restricts serine metabolism to preserve regulatory T cell function publication-title: Cell Metab. contributor: fullname: Brenner – volume: 12 year: 2021 ident: b0120 article-title: Celastrol attenuates lipid accumulation and stemness of clear cell renal cell carcinoma via CAV-1/LOX-1 pathway publication-title: Front. Pharmacol. contributor: fullname: Qin – volume: 8 start-page: 1411 year: 2018 end-page: 1420 ident: b0020 article-title: Naphthalene-based fluorescent probes for glutathione and their applications in living cells and patients with sepsis publication-title: Theranostics contributor: fullname: Yoon – volume: 400 start-page: 91 year: 1999 end-page: 108 ident: b0030 article-title: Direct electron transfer between heme-containing enzymes and electrodes as basis for third generation biosensors publication-title: Anal. Chim. Acta contributor: fullname: Gazaryan – volume: 42 start-page: 1472 year: 2021 end-page: 1485 ident: b0125 article-title: Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma publication-title: Acta Pharmacol. Sin. contributor: fullname: Qin – volume: 161 start-page: 999 year: 2015 end-page: 1011 ident: b0205 article-title: Treatment of obesity with celastrol publication-title: Cell contributor: fullname: Ozcan – volume: 143 start-page: 318 year: 2021 end-page: 325 ident: b0170 article-title: Rapid reaction, slow dissociation aggregation, and synergetic multicolor emission for imaging the restriction and regulation of biosynthesis of Cys and GSH publication-title: J. Am. Chem. Soc. contributor: fullname: Yin – volume: 662 start-page: 105 year: 2010 end-page: 127 ident: b0035 article-title: Review: Carbon nanotube based electrochemical sensors for biomolecules publication-title: Anal. Chim. Acta contributor: fullname: Venton – volume: 16 start-page: 1482 year: 2020 end-page: 1505 ident: b0090 article-title: RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells publication-title: Autophagy contributor: fullname: Zheng – volume: 9 start-page: 2 year: 2019 ident: b0110 article-title: Celastrol inhibits the growth of ovarian cancer cells in vitro and in vivo publication-title: Front. Oncol. contributor: fullname: Yan – volume: 11 start-page: 2714 year: 2020 ident: b0190 article-title: Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death publication-title: Nat. Commun. contributor: fullname: Puigserver – volume: 116 start-page: 18827 year: 2019 end-page: 18833 ident: b0150 article-title: Single-molecule and -particle probing crystal edge/corner as highly efficient photocatalytic sites on a single TiO(2) particle publication-title: PNAS contributor: fullname: Majima – volume: 7 start-page: 256 year: 2016 end-page: 260 ident: b0165 article-title: A minimalist fluorescent probe for differentiating Cys, Hcy and GSH in live cells publication-title: Chem. Sci. contributor: fullname: Sun – volume: 5 start-page: 242 year: 2020 end-page: 249 ident: b0055 article-title: Bioimaging of glutathione with a two-photon fluorescent probe and its potential application for surgery guide in laryngeal cancer publication-title: ACS Sens contributor: fullname: Yu – volume: 103 start-page: 52 year: 2019 end-page: 65.e6 ident: b0065 article-title: Glutathione S-transferase regulates mitochondrial populations in axons through increased glutathione oxidation publication-title: Neuron contributor: fullname: Züchner – volume: 37 start-page: 5435 year: 2018 end-page: 5450 ident: b0080 article-title: The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma publication-title: Oncogene contributor: fullname: Schulze – volume: 8 start-page: 6991 year: 2017 end-page: 7002 ident: b0175 article-title: A ratiometric fluorescent probe for imaging and quantifying anti-apoptotic effects of GSH under temperature stress publication-title: Chem. Sci. contributor: fullname: Chen – volume: 6 year: 2020 ident: b0145 article-title: Photoreduction of inorganic carbon(+IV) by elemental sulfur: implications for prebiotic synthesis in terrestrial hot springs publication-title: Sci. Adv. contributor: fullname: Lu – volume: 10 year: 2018 ident: b0085 article-title: Molecular pathways underlying cholesterol homeostasis publication-title: Nutrients contributor: fullname: Lottenberg – volume: 12 start-page: 5940 year: 2012 end-page: 5950 ident: b0135 article-title: A fast response highly selective probe for the detection of glutathione in human blood plasma publication-title: Sensors (Basel) contributor: fullname: Strongin – volume: 47 start-page: 289 year: 2021 end-page: 301 ident: b0220 article-title: Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis publication-title: Int. J. Mol. Med. contributor: fullname: Yang – volume: 50 start-page: 6013 year: 2021 end-page: 6041 ident: b0070 article-title: Engineering nanomedicine for glutathione depletion-augmented cancer therapy publication-title: Chem. Soc. Rev. contributor: fullname: Yang – volume: 12 start-page: 2300 year: 2022 end-page: 2314 ident: b0130 article-title: Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1 publication-title: Acta Pharm. Sin. B contributor: fullname: Wang – volume: 19 year: 2008 ident: b0025 article-title: Application of immobilized citrate lyase in a bioanalytical system for determination of citrates publication-title: Chemija contributor: fullname: Ramanavičius – volume: 135 start-page: 7674 year: 2013 end-page: 7680 ident: b0060 article-title: Reversible near-infrared fluorescent probe introducing tellurium to mimetic glutathione peroxidase for monitoring the redox cycles between peroxynitrite and glutathione in vivo publication-title: J. Am. Chem. Soc. contributor: fullname: Han – volume: 54 start-page: 572 year: 2019 end-page: 584 ident: b0100 article-title: OxLDL promotes lymphangiogenesis and lymphatic metastasis in gastric cancer by upregulating VEGF-C expression and secretion publication-title: Int. J. Oncol. contributor: fullname: Yang – volume: 18 start-page: 1133 year: 2019 end-page: 1144 ident: b0115 article-title: Modulation of lipid metabolism by celastrol publication-title: J. Proteome Res. contributor: fullname: Li – volume: 7 start-page: 1133 year: 2016 end-page: 1141 ident: b0180 article-title: Elucidation of ultraviolet radiation-induced cell responses and intracellular biomolecular dynamics in mammalian cells using surface-enhanced Raman spectroscopy publication-title: Chem. Sci. contributor: fullname: El-Sayed – volume: 20 start-page: 520 year: 2008 end-page: 526 ident: b0045 article-title: Unadulterated glucose biosensor based on direct electron transfer of glucose oxidase encapsulated chitosan modified glassy carbon electrode publication-title: Electroanal.: Int. J. Devoted Fundament. Pract. Aspects Electroanal. contributor: fullname: Jiao – volume: 6 year: 2020 ident: b0210 article-title: Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis publication-title: Sci. Adv. contributor: fullname: Lev – volume: 29 start-page: 1166 year: 2019 end-page: 1181.e6 ident: b0005 article-title: Deubiquitinases maintain protein homeostasis and survival of cancer cells upon glutathione depletion publication-title: Cell Metab. contributor: fullname: Brugge – volume: 223 start-page: 722 year: 2019 end-page: 735 ident: b0200 article-title: Friedelane-type triterpene cyclase in celastrol biosynthesis from publication-title: New Phytol. contributor: fullname: Gao – volume: 140 start-page: 1870 year: 2018 ident: WOS:000424851500041 article-title: A Mitochondria-Specific Fluorescent Probe for Visualizing Endogenous Hydrogen Cyanide Fluctuations in Neurons publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/jacs.7b12545 contributor: fullname: Long, LL – volume: 37 start-page: 5435 year: 2018 ident: WOS:000446312900005 article-title: The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma publication-title: ONCOGENE doi: 10.1038/s41388-018-0315-z contributor: fullname: Miess, H – volume: 7 start-page: 1133 year: 2016 ident: WOS:000368835300038 article-title: Elucidation of ultraviolet radiation-induced cell responses and intracellular biomolecular dynamics in mammalian cells using surface-enhanced Raman spectroscopy publication-title: CHEMICAL SCIENCE doi: 10.1039/c5sc03817k contributor: fullname: Panikkanvalappil, SR – volume: 161 start-page: 999 year: 2015 ident: WOS:000355152600009 article-title: Treatment of Obesity with Celastrol publication-title: CELL doi: 10.1016/j.cell.2015.05.011 contributor: fullname: Liu, JL – volume: 223 start-page: 722 year: 2019 ident: WOS:000472678700023 article-title: Friedelane-type triterpene cyclase in celastrol biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast publication-title: NEW PHYTOLOGIST doi: 10.1111/nph.15809 contributor: fullname: Zhou, JW – volume: 8 start-page: 6991 year: 2017 ident: WOS:000411730500032 article-title: A ratiometric fluorescent probe for imaging and quantifying anti-apoptotic effects of GSH under temperature stress publication-title: CHEMICAL SCIENCE doi: 10.1039/c7sc02888a contributor: fullname: Han, XY – volume: 10 start-page: ARTN 760 year: 2018 ident: WOS:000436507200104 article-title: Molecular Pathways Underlying Cholesterol Homeostasis publication-title: NUTRIENTS doi: 10.3390/nu10060760 contributor: fullname: Afonso, MS – volume: 116 start-page: 18827 year: 2019 ident: WOS:000486388400019 article-title: Single-molecule and -particle probing crystal edge/corner as highly efficient photocatalytic sites on a single TiO2 particle publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA doi: 10.1073/pnas.1907122116 contributor: fullname: Wang, WK – volume: 20 start-page: 520 year: 2008 ident: WOS:000254144500009 article-title: Unadulterated glucose biosensor based on direct electron transfer of glucose oxidase encapsulated chitosan modified glassy carbon electrode publication-title: ELECTROANALYSIS doi: 10.1002/elan.200704086 contributor: fullname: Zhao, CZ – volume: 29 start-page: 1166 year: 2019 ident: WOS:000467054100016 article-title: Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion publication-title: CELL METABOLISM doi: 10.1016/j.cmet.2019.01.020 contributor: fullname: Harris, IS – volume: 57 start-page: 333 year: 2016 ident: WOS:000371095500001 article-title: Srebp2: A master regulator of sterol and fatty acid synthesis publication-title: JOURNAL OF LIPID RESEARCH doi: 10.1194/jlr.C066712 contributor: fullname: Madison, BB – volume: 5 start-page: 242 year: 2020 ident: WOS:000510079300032 article-title: Bioimaging of Glutathione with a Two-Photon Fluorescent Probe and Its Potential Application for Surgery Guide in Laryngeal Cancer publication-title: ACS SENSORS doi: 10.1021/acssensors.9b02118 contributor: fullname: Zou, YX – volume: 16 start-page: 1482 year: 2020 ident: WOS:000495818500001 article-title: RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells publication-title: AUTOPHAGY doi: 10.1080/15548627.2019.1687985 contributor: fullname: Zhang, ZL – volume: 662 start-page: 105 year: 2010 ident: WOS:000275340600001 article-title: Review: Carbon nanotube based electrochemical sensors for biomolecules publication-title: ANALYTICA CHIMICA ACTA doi: 10.1016/j.aca.2010.01.009 contributor: fullname: Jacobs, CB – volume: 39 start-page: 819 year: 2009 ident: WOS:000268298100011 article-title: Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated from Celastrus regelii publication-title: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION doi: 10.1111/j.1365-2362.2009.02186.x contributor: fullname: Kim, DH – volume: 12 start-page: 2300 year: 2022 ident: WOS:000810964300001 article-title: Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1 publication-title: ACTA PHARMACEUTICA SINICA B doi: 10.1016/j.apsb.2021.12.007 contributor: fullname: Luo, P – volume: 7 start-page: 256 year: 2016 ident: WOS:000366826900028 article-title: A minimalist fluorescent probe for differentiating Cys, Hcy and GSH in live cells publication-title: CHEMICAL SCIENCE doi: 10.1039/c5sc02431e contributor: fullname: Zhang, HT – volume: 6 start-page: ARTN eaba8968 year: 2020 ident: WOS:000561426700017 article-title: Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis publication-title: SCIENCE ADVANCES doi: 10.1126/sciadv.aba8968 contributor: fullname: Verma, N – volume: 4 start-page: ARTN eaat0351 year: 2018 ident: WOS:000432440600051 article-title: Graphene biointerfaces for optical stimulation of cells publication-title: SCIENCE ADVANCES doi: 10.1126/sciadv.aat0351 contributor: fullname: Savchenko, A – volume: 31 start-page: ARTN 101410 year: 2020 ident: WOS:000533802200001 article-title: Sexual dimorphism in glutathione metabolism and glutathione-dependent responses publication-title: REDOX BIOLOGY doi: 10.1016/j.redox.2019.101410 contributor: fullname: Wang, LX – volume: 179 start-page: 964 year: 2019 ident: WOS:000493898000014 article-title: Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma publication-title: CELL doi: 10.1016/j.cell.2019.10.007 contributor: fullname: Clark, DJ – volume: 26 start-page: 267 year: 2010 ident: WOS:000282560500042 article-title: 1,10-Phenanthroline derivatives as mediators for glucose oxidase publication-title: BIOSENSORS & BIOELECTRONICS doi: 10.1016/j.bios.2010.05.005 contributor: fullname: Oztekin, Y – volume: 50 start-page: 6013 year: 2021 ident: WOS:000632993700001 article-title: Engineering nanomedicine for glutathione depletion-augmented cancer therapy publication-title: CHEMICAL SOCIETY REVIEWS doi: 10.1039/d0cs00718h contributor: fullname: Xiong, YX – volume: 18 start-page: 1133 year: 2019 ident: WOS:000460491800029 article-title: Modulation of Lipid Metabolism by Celastrol publication-title: JOURNAL OF PROTEOME RESEARCH doi: 10.1021/acs.jproteome.8b00797 contributor: fullname: Zhang, T – volume: 9 start-page: ARTN 2 year: 2019 ident: WOS:000456919400001 article-title: Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo publication-title: FRONTIERS IN ONCOLOGY doi: 10.3389/fonc.2019.00002 contributor: fullname: Xu, LN – volume: 47 start-page: 289 year: 2021 ident: WOS:000601400100024 article-title: Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis publication-title: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE doi: 10.3892/ijmm.2020.4770 contributor: fullname: He, ZQ – volume: 51 start-page: 9388 year: 2015 ident: WOS:000354997400037 article-title: A simple fluorescent off-on probe for the discrimination of cysteine from glutathione publication-title: CHEMICAL COMMUNICATIONS doi: 10.1039/c5cc02788h contributor: fullname: Gao, XH – volume: 6 start-page: ARTN eaay6350 year: 2020 ident: WOS:000507552400026 article-title: Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia publication-title: SCIENCE ADVANCES doi: 10.1126/sciadv.aay6350 contributor: fullname: Li, YX – volume: 42 start-page: 1472 year: 2021 ident: WOS:000597991300004 article-title: Celastrol induces lipophagy via the LXR alpha/ABCA1 pathway in clear cell renal cell carcinoma publication-title: ACTA PHARMACOLOGICA SINICA doi: 10.1038/s41401-020-00572-6 contributor: fullname: Zhang, CJ – volume: 13 start-page: 5443 year: 2020 ident: WOS:000539166200001 article-title: PSAT1 Regulated Oxidation-Reduction Balance Affects the Growth and Prognosis of Epithelial Ovarian Cancer publication-title: ONCOTARGETS AND THERAPY doi: 10.2147/OTT.S250066 contributor: fullname: Zhang, YQ – volume: 11 start-page: ARTN 2714 year: 2020 ident: WOS:000542983000006 article-title: Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death publication-title: NATURE COMMUNICATIONS doi: 10.1038/s41467-020-16423-1 contributor: fullname: Balsa, E – volume: 54 start-page: 572 year: 2019 ident: WOS:000454923900015 article-title: OxLDL promotes lymphangiogenesis and lymphatic metastasis in gastric cancer by upregulating VEGF-C expression and secretion publication-title: INTERNATIONAL JOURNAL OF ONCOLOGY doi: 10.3892/ijo.2018.4648 contributor: fullname: Ma, CQ – volume: 11 start-page: ARTN 1857 year: 2020 ident: WOS:000558826300002 article-title: Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy publication-title: NATURE COMMUNICATIONS doi: 10.1038/s41467-020-15730-x contributor: fullname: Jiang, YY – volume: 143 start-page: 318 year: 2021 ident: WOS:000611083700041 article-title: Rapid Reaction, Slow Dissociation Aggregation, and Synergetic Multicolor Emission for Imaging the Restriction and Regulation of Biosynthesis of Cys and GSH publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/jacs.0c10840 contributor: fullname: Yan, HM – volume: 12 start-page: 5940 year: 2012 ident: WOS:000304539200044 article-title: A Fast Response Highly Selective Probe for the Detection of Glutathione in Human Blood Plasma publication-title: SENSORS doi: 10.3390/s120505940 contributor: fullname: Guo, YX – volume: 21 start-page: 940 year: 2019 ident: WOS:000478029000007 article-title: The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome publication-title: NATURE CELL BIOLOGY doi: 10.1038/s41556-019-0356-8 contributor: fullname: Lee, SB – volume: 12 start-page: ARTN 658092 year: 2021 ident: WOS:000645613000001 article-title: Celastrol Attenuates Lipid Accumulation and Stemness of Clear Cell Renal Cell Carcinoma via CAV-1/LOX-1 Pathway publication-title: FRONTIERS IN PHARMACOLOGY doi: 10.3389/fphar.2021.658092 contributor: fullname: Zhang, CJ – volume: 10 start-page: 1295 year: 2018 ident: WOS:000433360300004 article-title: Exogenous glutathione contributes to cisplatin resistance in lung cancer A549 cells publication-title: AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH contributor: fullname: Lan, D – volume: 31 start-page: 920 year: 2020 ident: WOS:000544625500009 article-title: Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function publication-title: CELL METABOLISM doi: 10.1016/j.cmet.2020.03.004 contributor: fullname: Kurniawan, H – volume: 19 year: 2008 ident: 000953383600001.5 article-title: Application of immobilized citrate lyase in a bioanalytical system for determination of citrates publication-title: Chemija contributor: fullname: Kausait, A. – volume: 8 start-page: 1411 year: 2018 ident: WOS:000424515900017 article-title: Naphthalene-based fluorescent probes for glutathione and their applications in living cells and patients with sepsis publication-title: THERANOSTICS doi: 10.7150/thno.22252 contributor: fullname: Li, J – volume: 400 start-page: 91 year: 1999 ident: WOS:000084204200010 article-title: Direct electron transfer between heme-containing enzymes and electrodes as basis for third generation biosensors publication-title: ANALYTICA CHIMICA ACTA contributor: fullname: Gorton, L – volume: 103 start-page: 52 year: 2019 ident: WOS:000473726400007 article-title: Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation publication-title: NEURON doi: 10.1016/j.neuron.2019.04.017 contributor: fullname: Smith, GA – volume: 135 start-page: 7674 year: 2013 ident: WOS:000319551000041 article-title: Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/ja401360a contributor: fullname: Yu, FB – volume: 140 start-page: 1870 issue: 5 year: 2018 ident: 10.1016/j.bioorg.2023.106454_b0050 article-title: A Mitochondria-specific fluorescent probe for visualizing endogenous hydrogen cyanide fluctuations in neurons publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.7b12545 contributor: fullname: Long – volume: 54 start-page: 572 issue: 2 year: 2019 ident: 10.1016/j.bioorg.2023.106454_b0100 article-title: OxLDL promotes lymphangiogenesis and lymphatic metastasis in gastric cancer by upregulating VEGF-C expression and secretion publication-title: Int. J. Oncol. contributor: fullname: Ma – volume: 12 start-page: 2300 issue: 5 year: 2022 ident: 10.1016/j.bioorg.2023.106454_b0130 article-title: Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1 publication-title: Acta Pharm. Sin. B doi: 10.1016/j.apsb.2021.12.007 contributor: fullname: Luo – volume: 13 start-page: 5443 year: 2020 ident: 10.1016/j.bioorg.2023.106454_b0075 article-title: PSAT1 regulated oxidation-reduction balance affects the growth and prognosis of epithelial ovarian cancer publication-title: Onco Targets Ther doi: 10.2147/OTT.S250066 contributor: fullname: Zhang – volume: 16 start-page: 1482 issue: 8 year: 2020 ident: 10.1016/j.bioorg.2023.106454_b0090 article-title: RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells publication-title: Autophagy doi: 10.1080/15548627.2019.1687985 contributor: fullname: Zhang – volume: 18 start-page: 1133 issue: 3 year: 2019 ident: 10.1016/j.bioorg.2023.106454_b0115 article-title: Modulation of lipid metabolism by celastrol publication-title: J. Proteome Res. doi: 10.1021/acs.jproteome.8b00797 contributor: fullname: Zhang – volume: 8 start-page: 1411 issue: 5 year: 2018 ident: 10.1016/j.bioorg.2023.106454_b0020 article-title: Naphthalene-based fluorescent probes for glutathione and their applications in living cells and patients with sepsis publication-title: Theranostics doi: 10.7150/thno.22252 contributor: fullname: Li – volume: 8 start-page: 6991 issue: 10 year: 2017 ident: 10.1016/j.bioorg.2023.106454_b0175 article-title: A ratiometric fluorescent probe for imaging and quantifying anti-apoptotic effects of GSH under temperature stress publication-title: Chem. Sci. doi: 10.1039/C7SC02888A contributor: fullname: Han – volume: 9 start-page: 2 year: 2019 ident: 10.1016/j.bioorg.2023.106454_b0110 article-title: Celastrol inhibits the growth of ovarian cancer cells in vitro and in vivo publication-title: Front. Oncol. doi: 10.3389/fonc.2019.00002 contributor: fullname: Xu – volume: 7 start-page: 256 issue: 1 year: 2016 ident: 10.1016/j.bioorg.2023.106454_b0165 article-title: A minimalist fluorescent probe for differentiating Cys, Hcy and GSH in live cells publication-title: Chem. Sci. doi: 10.1039/C5SC02431E contributor: fullname: Zhang – volume: 143 start-page: 318 issue: 1 year: 2021 ident: 10.1016/j.bioorg.2023.106454_b0170 article-title: Rapid reaction, slow dissociation aggregation, and synergetic multicolor emission for imaging the restriction and regulation of biosynthesis of Cys and GSH publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.0c10840 contributor: fullname: Yan – volume: 47 start-page: 289 issue: 1 year: 2021 ident: 10.1016/j.bioorg.2023.106454_b0220 article-title: Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis publication-title: Int. J. Mol. Med. doi: 10.3892/ijmm.2020.4770 contributor: fullname: He – volume: 19 issue: 2 year: 2008 ident: 10.1016/j.bioorg.2023.106454_b0025 article-title: Application of immobilized citrate lyase in a bioanalytical system for determination of citrates publication-title: Chemija contributor: fullname: Kaušaitė – volume: 4 start-page: eaat0351 issue: 5 year: 2018 ident: 10.1016/j.bioorg.2023.106454_b0160 article-title: Graphene biointerfaces for optical stimulation of cells publication-title: Sci. Adv. doi: 10.1126/sciadv.aat0351 contributor: fullname: Savchenko – volume: 6 issue: 47 year: 2020 ident: 10.1016/j.bioorg.2023.106454_b0145 article-title: Photoreduction of inorganic carbon(+IV) by elemental sulfur: implications for prebiotic synthesis in terrestrial hot springs publication-title: Sci. Adv. doi: 10.1126/sciadv.abc3687 contributor: fullname: Li – volume: 21 start-page: 940 issue: 8 year: 2019 ident: 10.1016/j.bioorg.2023.106454_b0185 article-title: The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome publication-title: Nat. Cell Biol. doi: 10.1038/s41556-019-0356-8 contributor: fullname: Lee – volume: 7 start-page: 1133 issue: 2 year: 2016 ident: 10.1016/j.bioorg.2023.106454_b0180 article-title: Elucidation of ultraviolet radiation-induced cell responses and intracellular biomolecular dynamics in mammalian cells using surface-enhanced Raman spectroscopy publication-title: Chem. Sci. doi: 10.1039/C5SC03817K contributor: fullname: Panikkanvalappil – volume: 42 start-page: 1472 issue: 9 year: 2021 ident: 10.1016/j.bioorg.2023.106454_b0125 article-title: Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma publication-title: Acta Pharmacol. Sin. doi: 10.1038/s41401-020-00572-6 contributor: fullname: Zhang – volume: 400 start-page: 91 issue: 1–3 year: 1999 ident: 10.1016/j.bioorg.2023.106454_b0030 article-title: Direct electron transfer between heme-containing enzymes and electrodes as basis for third generation biosensors publication-title: Anal. Chim. Acta doi: 10.1016/S0003-2670(99)00610-8 contributor: fullname: Gorton – volume: 103 start-page: 52 issue: 1 year: 2019 ident: 10.1016/j.bioorg.2023.106454_b0065 article-title: Glutathione S-transferase regulates mitochondrial populations in axons through increased glutathione oxidation publication-title: Neuron doi: 10.1016/j.neuron.2019.04.017 contributor: fullname: Smith – volume: 20 start-page: 520 issue: 5 year: 2008 ident: 10.1016/j.bioorg.2023.106454_b0045 article-title: Unadulterated glucose biosensor based on direct electron transfer of glucose oxidase encapsulated chitosan modified glassy carbon electrode publication-title: Electroanal.: Int. J. Devoted Fundament. Pract. Aspects Electroanal. doi: 10.1002/elan.200704086 contributor: fullname: Zhao – volume: 10 issue: 6 year: 2018 ident: 10.1016/j.bioorg.2023.106454_b0085 article-title: Molecular pathways underlying cholesterol homeostasis publication-title: Nutrients doi: 10.3390/nu10060760 contributor: fullname: Afonso – volume: 12 start-page: 5940 issue: 5 year: 2012 ident: 10.1016/j.bioorg.2023.106454_b0135 article-title: A fast response highly selective probe for the detection of glutathione in human blood plasma publication-title: Sensors (Basel) doi: 10.3390/s120505940 contributor: fullname: Guo – volume: 31 year: 2020 ident: 10.1016/j.bioorg.2023.106454_b0015 article-title: Sexual dimorphism in glutathione metabolism and glutathione-dependent responses publication-title: Redox Biol. doi: 10.1016/j.redox.2019.101410 contributor: fullname: Wang – volume: 26 start-page: 267 issue: 1 year: 2010 ident: 10.1016/j.bioorg.2023.106454_b0040 article-title: 1, 10-Phenanthroline derivatives as mediators for glucose oxidase publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2010.05.005 contributor: fullname: Oztekin – volume: 662 start-page: 105 issue: 2 year: 2010 ident: 10.1016/j.bioorg.2023.106454_b0035 article-title: Review: Carbon nanotube based electrochemical sensors for biomolecules publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2010.01.009 contributor: fullname: Jacobs – volume: 57 start-page: 333 issue: 3 year: 2016 ident: 10.1016/j.bioorg.2023.106454_b0105 article-title: Srebp2: a master regulator of sterol and fatty acid synthesis publication-title: J. Lipid Res. doi: 10.1194/jlr.C066712 contributor: fullname: Madison – volume: 51 start-page: 9388 issue: 45 year: 2015 ident: 10.1016/j.bioorg.2023.106454_b0140 article-title: A simple fluorescent off-on probe for the discrimination of cysteine from glutathione publication-title: Chem. Commun. (Camb.) doi: 10.1039/C5CC02788H contributor: fullname: Gao – volume: 11 start-page: 1857 issue: 1 year: 2020 ident: 10.1016/j.bioorg.2023.106454_b0215 article-title: Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy publication-title: Nat. Commun. doi: 10.1038/s41467-020-15730-x contributor: fullname: Jiang – volume: 135 start-page: 7674 issue: 20 year: 2013 ident: 10.1016/j.bioorg.2023.106454_b0060 article-title: Reversible near-infrared fluorescent probe introducing tellurium to mimetic glutathione peroxidase for monitoring the redox cycles between peroxynitrite and glutathione in vivo publication-title: J. Am. Chem. Soc. doi: 10.1021/ja401360a contributor: fullname: Yu – volume: 39 start-page: 819 issue: 9 year: 2009 ident: 10.1016/j.bioorg.2023.106454_b0195 article-title: Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated from Celastrus regelii publication-title: Eur. J. Clin. Invest. doi: 10.1111/j.1365-2362.2009.02186.x contributor: fullname: Kim – volume: 5 start-page: 242 issue: 1 year: 2020 ident: 10.1016/j.bioorg.2023.106454_b0055 article-title: Bioimaging of glutathione with a two-photon fluorescent probe and its potential application for surgery guide in laryngeal cancer publication-title: ACS Sens doi: 10.1021/acssensors.9b02118 contributor: fullname: Zou – volume: 116 start-page: 18827 issue: 38 year: 2019 ident: 10.1016/j.bioorg.2023.106454_b0150 article-title: Single-molecule and -particle probing crystal edge/corner as highly efficient photocatalytic sites on a single TiO(2) particle publication-title: PNAS doi: 10.1073/pnas.1907122116 contributor: fullname: Wang – volume: 161 start-page: 999 issue: 5 year: 2015 ident: 10.1016/j.bioorg.2023.106454_b0205 article-title: Treatment of obesity with celastrol publication-title: Cell doi: 10.1016/j.cell.2015.05.011 contributor: fullname: Liu – volume: 37 start-page: 5435 issue: 40 year: 2018 ident: 10.1016/j.bioorg.2023.106454_b0080 article-title: The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma publication-title: Oncogene doi: 10.1038/s41388-018-0315-z contributor: fullname: Miess – volume: 10 start-page: 1295 issue: 5 year: 2018 ident: 10.1016/j.bioorg.2023.106454_b0155 article-title: Exogenous glutathione contributes to cisplatin resistance in lung cancer A549 cells publication-title: Am. J. Transl. Res. contributor: fullname: Lan – volume: 50 start-page: 6013 issue: 10 year: 2021 ident: 10.1016/j.bioorg.2023.106454_b0070 article-title: Engineering nanomedicine for glutathione depletion-augmented cancer therapy publication-title: Chem. Soc. Rev. doi: 10.1039/D0CS00718H contributor: fullname: Xiong – volume: 29 start-page: 1166 issue: 5 year: 2019 ident: 10.1016/j.bioorg.2023.106454_b0005 article-title: Deubiquitinases maintain protein homeostasis and survival of cancer cells upon glutathione depletion publication-title: Cell Metab. doi: 10.1016/j.cmet.2019.01.020 contributor: fullname: Harris – volume: 6 issue: 34 year: 2020 ident: 10.1016/j.bioorg.2023.106454_b0210 article-title: Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis publication-title: Sci. Adv. doi: 10.1126/sciadv.aba8968 contributor: fullname: Verma – volume: 11 start-page: 2714 issue: 1 year: 2020 ident: 10.1016/j.bioorg.2023.106454_b0190 article-title: Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death publication-title: Nat. Commun. doi: 10.1038/s41467-020-16423-1 contributor: fullname: Balsa – ident: 10.1016/j.bioorg.2023.106454_b0095 doi: 10.1016/j.cell.2019.10.007 – volume: 12 year: 2021 ident: 10.1016/j.bioorg.2023.106454_b0120 article-title: Celastrol attenuates lipid accumulation and stemness of clear cell renal cell carcinoma via CAV-1/LOX-1 pathway publication-title: Front. Pharmacol. contributor: fullname: Zhang – volume: 31 start-page: 920 issue: 5 year: 2020 ident: 10.1016/j.bioorg.2023.106454_b0010 article-title: Glutathione restricts serine metabolism to preserve regulatory T cell function publication-title: Cell Metab. doi: 10.1016/j.cmet.2020.03.004 contributor: fullname: Kurniawan – volume: 223 start-page: 722 issue: 2 year: 2019 ident: 10.1016/j.bioorg.2023.106454_b0200 article-title: Friedelane-type triterpene cyclase in celastrol biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast publication-title: New Phytol. doi: 10.1111/nph.15809 contributor: fullname: Zhou |
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•GSH-specific fluorescent probe for GSH detection in clinical samples and live cell and tumor imaging.•Celastrol induces ferroptosis in... Glutathione (GSH) is closely related to the occurrence and development of tumors. The intracellular GSH levels are abnormally altered when tumor cells undergo... |
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SubjectTerms | Biochemistry & Molecular Biology Carcinoma Carcinoma, Renal Cell Celastrol Chemistry Chemistry, Organic Clear cell renal cell carcinoma Ferroptosis Fluorescence probe Fluorescent Dyes - pharmacology Glutathione Glutathione - metabolism Humans Kidney Neoplasms Life Sciences & Biomedicine Physical Sciences Science & Technology |
Title | An ultrasensitive GSH-specific fluorescent probe unveils celastrol-induced ccRCC ferroptosis |
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