YWHAH Genetic Variants are Associated with Increased Hypoxia Inducible Factor-1α/Vascular Endothelial Growth Factor in Egyptian Rheumatoid Arthritis Patients

• Published in: Biochemical genetics Vol. 60; no. 6; pp. 1986 - 1999
• Main Authors: Fattah, Shaimaa A., Fattah, Maha A. Abdel, Mesbah, Noha M., Saleh, Samy M., Abo-Elmatty, Dina M., Mehanna, Eman T.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2022; Springer Nature B.V
• Subjects: Alleles; Angiogenesis; Arthritis; Autoimmune diseases; Biochemistry; Biomarkers; Biomedical and Life Sciences; Biomedicine; blood serum; Enzyme-linked immunosorbent assay; Gene expression; Gene polymorphism; Genetic diversity; genetic polymorphism; Genetic variance; Genotyping; Growth factors; Human Genetics; Hypoxia; Hypoxia-inducible factor 1a; Inflammation; Medical Microbiology; Original Article; Parameters; Patients; Polymorphism; prognosis; quantitative polymerase chain reaction; Rheumatoid arthritis; risk; Serum levels; Vascular endothelial growth factor; vascular endothelial growth factors; Zoology; 14–3-3 η; HIF-1α; Rheumatoid arthritis; VEGF; rs2858750 polymorphism; YWHAH

The 14–3-3 Eta (14–3-3 η) biomarker platform is a relatively recent discovery with the potential to significantly address the diagnosis and prognosis of rheumatoid arthritis (RA) disease. Hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) have been implicated in inflamma...