A new perspective of mechanosensitive pannexin-1 channels in cancer metastasis： clues for the treatment of other stress-induced diseases

• Published in: Acta biochimica et biophysica Sinica Vol. 48; no. 5; pp. 487 - 489
• Main Authors: Wu, Di, Li, Lanfang, Chen, Linxi
• Format: Journal Article
• Language: English
• Published: China Oxford University Press 01.05.2016
• Subjects: Adenosine Triphosphate - metabolism; Biomechanical Phenomena; Cell Survival - physiology; Connexins - antagonists & inhibitors; Connexins - genetics; Connexins - metabolism; Humans; Mutation; Neoplasm Metastasis - genetics; Neoplasm Metastasis - physiopathology; Neoplasm Metastasis - therapy; Nerve Tissue Proteins - antagonists & inhibitors; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Research Highlight; Stress, Mechanical; 应激性疾病; 敏感; 治疗; 癌症患者; 肿瘤细胞; 肿瘤转移; 转移过程; 通道

Cancer metastasis is a process that cancer cells deviate from the primary site and spread to the other areas to form new colonies, which is the leading cause of death in cancer patients. During metastatic progression, circulating cancer cells lodge within the microvasculature of end organs, where mo...