A new perspective of mechanosensitive pannexin-1 channels in cancer metastasis： clues for the treatment of other stress-induced diseases

Cancer metastasis is a process that cancer cells deviate from the primary site and spread to the other areas to form new colonies, which is the leading cause of death in cancer patients. During metastatic progression, circulating cancer cells lodge within the microvasculature of end organs, where mo...

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Bibliographic Details
Published inActa biochimica et biophysica Sinica Vol. 48; no. 5; pp. 487 - 489
Main Authors Wu, Di, Li, Lanfang, Chen, Linxi
Format Journal Article
LanguageEnglish
Published China Oxford University Press 01.05.2016
Subjects
Adenosine Triphosphate - metabolism
Biomechanical Phenomena
Cell Survival - physiology
Connexins - antagonists & inhibitors
Connexins - genetics
Connexins - metabolism
Humans
Mutation
Neoplasm Metastasis - genetics
Neoplasm Metastasis - physiopathology
Neoplasm Metastasis - therapy
Nerve Tissue Proteins - antagonists & inhibitors
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
Research Highlight
Stress, Mechanical
应激性疾病
敏感
治疗
癌症患者
肿瘤细胞
肿瘤转移
转移过程
通道
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Summary:Cancer metastasis is a process that cancer cells deviate from the primary site and spread to the other areas to form new colonies, which is the leading cause of death in cancer patients. During metastatic progression, circulating cancer cells lodge within the microvasculature of end organs, where most of them die from mechanical deformation.
Bibliography:31-1940/Q
Cancer metastasis is a process that cancer cells deviate from the primary site and spread to the other areas to form new colonies, which is the leading cause of death in cancer patients. During metastatic progression, circulating cancer cells lodge within the microvasculature of end organs, where most of them die from mechanical deformation.
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These authors contributed equally to this work.
ISSN:1672-9145
1745-7270
1745-7270
DOI:10.1093/abbs/gmw018