A new perspective of mechanosensitive pannexin-1 channels in cancer metastasis： clues for the treatment of other stress-induced diseases
Cancer metastasis is a process that cancer cells deviate from the primary site and spread to the other areas to form new colonies, which is the leading cause of death in cancer patients. During metastatic progression, circulating cancer cells lodge within the microvasculature of end organs, where mo...
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| Published in | Acta biochimica et biophysica Sinica Vol. 48; no. 5; pp. 487 - 489 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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China
Oxford University Press
01.05.2016
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| Abstract | Cancer metastasis is a process that cancer cells deviate from the primary site and spread to the other areas to form new colonies, which is the leading cause of death in cancer patients. During metastatic progression, circulating cancer cells lodge within the microvasculature of end organs, where most of them die from mechanical deformation. |
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| AbstractList | Cancer metastasis is a process that cancer cells deviate from the primary site and spread to the other areas to form new colonies, which is the leading cause of death in cancer patients. During metastatic progression, circulating cancer cells lodge within the microvasculature of end organs, where most of them die from mechanical deformation. |
| Author | Di Wu Lanfang Li Linxi Chen |
| AuthorAffiliation | Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27025600$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_bbcan_2020_188380 crossref_primary_10_1002_jcp_25906 crossref_primary_10_1016_j_jid_2019_06_148 crossref_primary_10_1002_JPER_21_0339 crossref_primary_10_1016_j_pbiomolbio_2023_09_003 crossref_primary_10_1038_s41389_022_00384_9 |
| Cites_doi | 10.1073/pnas.86.5.1662 10.1038/bjc.1997.6 10.1093/abbs/gmv028 10.1038/ncb3194 10.1016/S0960-9822(00)00576-5 10.1017/S1740925X08000069 10.1158/0008-5472.CAN-06-1396 10.1038/cdd.2014.117 10.1074/jbc.M112.377176 10.1124/jpet.108.146365 10.4161/cc.8.22.10026 10.1152/ajpcell.00227.2008 10.1152/ajpcell.00092.2015 10.4161/chan.3.5.9568 10.1074/jbc.M111.306522 10.1098/rstb.2014.0191 10.1038/emboj.2008.237 10.1111/jth.12566 10.1152/ajpcell.00097.2007 10.1002/phy2.227 10.1016/j.juro.2015.05.080 10.1074/jbc.M115.650218 10.4049/jimmunol.0901247 10.1016/j.bcp.2013.11.007 10.1074/jbc.M113.460865 10.1016/j.neuroscience.2008.08.036 10.1002/jnr.21675 10.1093/molehr/6.5.435 |
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| Notes | 31-1940/Q Cancer metastasis is a process that cancer cells deviate from the primary site and spread to the other areas to form new colonies, which is the leading cause of death in cancer patients. During metastatic progression, circulating cancer cells lodge within the microvasculature of end organs, where most of them die from mechanical deformation. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
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| SubjectTerms | Adenosine Triphosphate - metabolism Biomechanical Phenomena Cell Survival - physiology Connexins - antagonists & inhibitors Connexins - genetics Connexins - metabolism Humans Mutation Neoplasm Metastasis - genetics Neoplasm Metastasis - physiopathology Neoplasm Metastasis - therapy Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Research Highlight Stress, Mechanical 应激性疾病 敏感 治疗 癌症患者 肿瘤细胞 肿瘤转移 转移过程 通道 |
| Title | A new perspective of mechanosensitive pannexin-1 channels in cancer metastasis： clues for the treatment of other stress-induced diseases |
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