CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study

• Published in: Archives of toxicology Vol. 98; no. 10; pp. 3241 - 3257
• Main Authors: Wang, Yewei, Charkoftaki, Georgia, Orlicky, David J., Davidson, Emily, Aalizadeh, Reza, Sun, Ning, Ginsberg, Gary, Thompson, David C., Vasiliou, Vasilis, Chen, Ying
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2024; Springer Nature B.V
• Subjects: Animals; antioxidant activity; Biomedical and Life Sciences; Biomedicine; Carcinogenicity; Carcinogens; Carcinogens - metabolism; Carcinogens - toxicity; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - genetics; Chemical and Drug Induced Liver Injury - metabolism; Chemical and Drug Induced Liver Injury - pathology; Contaminants; Cytochrome P-450 CYP2E1 - genetics; Cytochrome P-450 CYP2E1 - metabolism; Cytotoxicity; Deoxyribonucleic acid; Dioxanes - toxicity; DNA; DNA Damage; DNA repair; Drinking water; Environmental Health; enzymes; Exposure; Female; females; Genotoxicity; Glutathione; Glutathione - metabolism; hepatotoxicity; Lipid peroxidation; Lipids; Liver; Liver - drug effects; Liver - metabolism; Liver - pathology; Male; Males; Metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Occupational Medicine/Industrial Medicine; Oxidation; Oxidative metabolism; Oxidative stress; Oxidative Stress - drug effects; Peroxidation; Pharmacology/Toxicology; pollution; Risk assessment; Toxicity; Toxicokinetics and Metabolism; Water damage; Water pollution; Water contaminant; Oxidative stress; Liver carcinogenesis; Cytochrome p450; Oxidative DNA damage

1,4-Dioxane (DX), an emerging water contaminant, is classified as a Group 2B liver carcinogen based on animal studies. Understanding of the mechanisms of action of DX liver carcinogenicity is important for the risk assessment and control of this environmental pollution. Previous studies demonstrate...