Cross-sectional relationships between general and central adiposity and plasma amino acids in Chinese adults

Adiposity is an important determinant of blood metabolites, but little is known about the variations of blood amino acids according to general and central adiposity status among Chinese population. This study included 187 females and 322 males who were cancer-free subjects randomly selected from two...

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Published in	Amino acids Vol. 55; no. 5; pp. 651 - 663
Main Authors	Shen, Qiu-Ming, Tan, Yu-Ting, Wang, Jing, Fang, Jie, Liu, Da-Ke, Li, Hong-Lan, Xiang, Yong-Bing
Format	Journal Article
Language	English
Published	Vienna Springer Vienna 01.05.2023 Springer Nature B.V
Subjects	Adipose tissue Adiposity Adult Adults Alanine Amino acids Amino Acids - blood Analytical Chemistry Asparagine Aspartic acid Biochemical Engineering Biochemistry Biomarkers Biomedical and Life Sciences Blood Cancer China Cross-sectional studies East Asian People Female Females Glutamic acid Glutamine Glycine Humans Isoleucine Leucine Life Sciences Liquid chromatography Male Males Mass spectrometry Mass spectroscopy Metabolites Neurobiology Original Article Phenylalanine Plasma Population studies Proteomics Pyroglutamic acid Pyrrolidonecarboxylic Acid Regression analysis Regression models serine tandem mass spectrometry ultra-performance liquid chromatography Valine China Metabolomics Correlation Amino acid Cross-sectional study Adiposity
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ISSN	0939-4451 1438-2199 1438-2199
DOI	10.1007/s00726-023-03258-5

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Abstract	Adiposity is an important determinant of blood metabolites, but little is known about the variations of blood amino acids according to general and central adiposity status among Chinese population. This study included 187 females and 322 males who were cancer-free subjects randomly selected from two cohorts in Shanghai, China. Participants’ plasma concentrations of amino acids were measured by ultra-performance liquid chromatography coupled to tandem mass spectrometry. Linear regression models were used to examine the cross-sectional correlations between general and central adiposity and amino acid levels. A total of 35 amino acids in plasma were measured in this study. In females, alanine, aspartic acid and pyroglutamic acid were positively correlated with general adiposity. In males, glutamic acid, aspartic acid, valine and pyroglutamic acid showed positive correlations, and glutamine, serine and glycine showed negative correlations with both general and central adiposity; phenylalanine, isoleucine and leucine were positively correlated and N-phenylacetylglutamine was negatively correlated with general adiposity; asparagine was negatively correlated with central adiposity. In summary, general adiposity and central adiposity were correlated with the concentrations of specific plasma amino acids among cancer-free female and male adults in China. Adiposity–metabolite characteristics and relationships should be considered when studying blood biomarkers for adiposity-related health outcomes.
AbstractList	Adiposity is an important determinant of blood metabolites, but little is known about the variations of blood amino acids according to general and central adiposity status among Chinese population. This study included 187 females and 322 males who were cancer-free subjects randomly selected from two cohorts in Shanghai, China. Participants’ plasma concentrations of amino acids were measured by ultra-performance liquid chromatography coupled to tandem mass spectrometry. Linear regression models were used to examine the cross-sectional correlations between general and central adiposity and amino acid levels. A total of 35 amino acids in plasma were measured in this study. In females, alanine, aspartic acid and pyroglutamic acid were positively correlated with general adiposity. In males, glutamic acid, aspartic acid, valine and pyroglutamic acid showed positive correlations, and glutamine, serine and glycine showed negative correlations with both general and central adiposity; phenylalanine, isoleucine and leucine were positively correlated and N-phenylacetylglutamine was negatively correlated with general adiposity; asparagine was negatively correlated with central adiposity. In summary, general adiposity and central adiposity were correlated with the concentrations of specific plasma amino acids among cancer-free female and male adults in China. Adiposity–metabolite characteristics and relationships should be considered when studying blood biomarkers for adiposity-related health outcomes. Adiposity is an important determinant of blood metabolites, but little is known about the variations of blood amino acids according to general and central adiposity status among Chinese population. This study included 187 females and 322 males who were cancer-free subjects randomly selected from two cohorts in Shanghai, China. Participants' plasma concentrations of amino acids were measured by ultra-performance liquid chromatography coupled to tandem mass spectrometry. Linear regression models were used to examine the cross-sectional correlations between general and central adiposity and amino acid levels. A total of 35 amino acids in plasma were measured in this study. In females, alanine, aspartic acid and pyroglutamic acid were positively correlated with general adiposity. In males, glutamic acid, aspartic acid, valine and pyroglutamic acid showed positive correlations, and glutamine, serine and glycine showed negative correlations with both general and central adiposity; phenylalanine, isoleucine and leucine were positively correlated and N-phenylacetylglutamine was negatively correlated with general adiposity; asparagine was negatively correlated with central adiposity. In summary, general adiposity and central adiposity were correlated with the concentrations of specific plasma amino acids among cancer-free female and male adults in China. Adiposity-metabolite characteristics and relationships should be considered when studying blood biomarkers for adiposity-related health outcomes.Adiposity is an important determinant of blood metabolites, but little is known about the variations of blood amino acids according to general and central adiposity status among Chinese population. This study included 187 females and 322 males who were cancer-free subjects randomly selected from two cohorts in Shanghai, China. Participants' plasma concentrations of amino acids were measured by ultra-performance liquid chromatography coupled to tandem mass spectrometry. Linear regression models were used to examine the cross-sectional correlations between general and central adiposity and amino acid levels. A total of 35 amino acids in plasma were measured in this study. In females, alanine, aspartic acid and pyroglutamic acid were positively correlated with general adiposity. In males, glutamic acid, aspartic acid, valine and pyroglutamic acid showed positive correlations, and glutamine, serine and glycine showed negative correlations with both general and central adiposity; phenylalanine, isoleucine and leucine were positively correlated and N-phenylacetylglutamine was negatively correlated with general adiposity; asparagine was negatively correlated with central adiposity. In summary, general adiposity and central adiposity were correlated with the concentrations of specific plasma amino acids among cancer-free female and male adults in China. Adiposity-metabolite characteristics and relationships should be considered when studying blood biomarkers for adiposity-related health outcomes.
Author	Tan, Yu-Ting Xiang, Yong-Bing Shen, Qiu-Ming Fang, Jie Li, Hong-Lan Wang, Jing Liu, Da-Ke
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Snippet	Adiposity is an important determinant of blood metabolites, but little is known about the variations of blood amino acids according to general and central...
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StartPage	651
SubjectTerms	Adipose tissue Adiposity Adult Adults Alanine Amino acids Amino Acids - blood Analytical Chemistry Asparagine Aspartic acid Biochemical Engineering Biochemistry Biomarkers Biomedical and Life Sciences Blood Cancer China Cross-sectional studies East Asian People Female Females Glutamic acid Glutamine Glycine Humans Isoleucine Leucine Life Sciences Liquid chromatography Male Males Mass spectrometry Mass spectroscopy Metabolites Neurobiology Original Article Phenylalanine Plasma Population studies Proteomics Pyroglutamic acid Pyrrolidonecarboxylic Acid Regression analysis Regression models serine tandem mass spectrometry ultra-performance liquid chromatography Valine
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Title	Cross-sectional relationships between general and central adiposity and plasma amino acids in Chinese adults
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