All that glitters is not gold: Panning cytotoxic natural products and derivatives with a fused tricyclic backbone by the estimation of their leadlikeness for cancer treatment

• Published in: European journal of medicinal chemistry Vol. 166; pp. 1 - 10
• Main Authors: Klein-Júnior, Luiz Carlos, Corrêa, Rogério, Vander Heyden, Yvan, Cechinel Filho, Valdir
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 15.03.2019
• Subjects: Cancer; Cytotoxic; Hit-to-lead; Leadlikeness; Xanthone; Xanthone; Cytotoxic; Hit-to-lead; Leadlikeness; Cancer

Tricyclic compounds call the attention because of their pharmacological properties, and are considered a preferred platform for the development of drugs. Especially, in cancer treatment, these planar compounds are known for their ability to stack with DNA base pairs, acting as intercalators. In this...