Evaluation of protein release from chitosan-aginate microcapsules produced using external or internal gelation

• Published in: Journal of microencapsulation Vol. 18; no. 4; pp. 433 - 441
• Main Authors: VANDENBERG, G. W, DE LA NOÜE, J
• Format: Journal Article
• Language: English
• Published: Colchester Informa UK Ltd 2001; Taylor & Francis; Informa
• Subjects: Biological and medical sciences; Gelation Alginate Chitosan Microcapsule; General pharmacology; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Encapsulation; Pharmaceutical technology; Control release polymer; Gelation; Microcapsule; Albumin; Drug carrier; Alginates; Fabrication property relation; Protein; Manufacturing process; Formulation; Dosage form; pH; Fabrication structure relation; Chitosan; Physicochemical properties; Physical structure

A series of experiments was undertaken to evaluate the diffusion of a model protein, i.e. bovine serum albumin (BSA), from chitosan-alginate microcapsules produced using either internal or external gelation. Diffusion of BSA was quantified during the microcapsule manufacture processes (gelation, was...