Controlled Human Infection With Bordetella pertussis Induces Asymptomatic, Immunizing Colonization

• Published in: Clinical infectious diseases Vol. 71; no. 2; pp. 403 - 411
• Main Authors: de Graaf, Hans, Ibrahim, Muktar, Hill, Alison R, Gbesemete, Diane, Vaughan, Andrew T, Gorringe, Andrew, Preston, Andrew, Buisman, Annemarie M, Faust, Saul N, Kester, Kent E, Berbers, Guy A M, Diavatopoulos, Dimitri A, Read, Robert C
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 11.07.2020
• Subjects: Adolescent; Adult; and Commentaries; Azithromycin - therapeutic use; Bordetella pertussis; Humans; Middle Aged; Nasopharynx; Pertussis Vaccine; Whooping Cough - prevention & control; Young Adult; carriage; mmune response; human challenge; Bordetella pertussis
• ISSN: 1058-4838; 1537-6591; 1537-6591
• DOI: 10.1093/cid/ciz840

Abstract Background Bordetella pertussis is among the leading causes of vaccine-preventable deaths and morbidity globally. Human asymptomatic carriage as a reservoir for community transmission of infections might be a target of future vaccine strategies, but has not been demonstrated. Our objective...