Brain organoids: advances, applications and challenges

• Published in: Development (Cambridge) Vol. 146; no. 8
• Main Authors: Qian, Xuyu, Song, Hongjun, Ming, Guo-li
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 15.04.2019
• Subjects: Animals; Brain - cytology; Brain - metabolism; Brain - pathology; Humans; Models, Biological; Organoids - cytology; Organoids - metabolism; Organoids - pathology; Review; Neuroscience; Brain organoids; Stem cell

Brain organoids are self-assembled three-dimensional aggregates generated from pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic human brain. As such, they have emerged as novel model systems that can be used to investigate human brain development and disorders...