MicroRNA‐34a Mediates the Aldosterone‐Induced Acceleration of Endothelial Senescence

• Published in: International journal of hypertension Vol. 2025; no. 1; p. 2339598
• Main Authors: Jia, Minyue, Lin, Liya, Yang, Boyun, Yu, Hanxiao, Zhong, Shan, Xu, Xiaohong, Song, Xiaoxiao
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2025; Wiley
• Subjects: Aldosterone; Apoptosis; Bioinformatics; Cardiovascular disease; Cell cycle; Cell growth; Corticosteroids; Endothelium; Genes; Hypertension; MicroRNA; MicroRNAs; Reagents; Senescence; Telomerase; North Carolina; China; United States > US; Germany; microRNA-34a; NOTCH1; cellular senescence; endothelial dysfunction; aldosterone

Inappropriate aldosterone production relative to sodium status is known to induce arterial hypertension and cause detrimental effects on endothelium and vascular remodeling. This study investigated whether microRNAs (miRs) serve as key mediators of aldosterone’s effects on endothelial dysfunction. U...