Sericin modulates learning and memory behaviors by tuning of antioxidant, inflammatory, and apoptotic markers in the hippocampus of aged mice

• Published in: Molecular biology reports Vol. 48; no. 2; pp. 1371 - 1382
• Main Authors: Seyedaghamiri, Fatemehsadat, Farajdokht, Fereshteh, Vatandoust, Seyed Mehdi, Mahmoudi, Javad, Khabbaz, Aytak, Sadigh-Eteghad, Saeed
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.02.2021; Springer Nature B.V
• Subjects: Aging; Animal Anatomy; Animal Biochemistry; Animals; anti-inflammatory activity; Anti-Inflammatory Agents - pharmacology; Antioxidants; Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; Avoidance behavior; Behavior; Biomedical and Life Sciences; Disease Models, Animal; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Histology; Humans; IL-1β; Inflammation; Inflammation - drug therapy; Inflammation - genetics; Inflammation - pathology; Interleukin 10; Interleukin-1beta - genetics; Life Sciences; Maze Learning - drug effects; memory; Memory - drug effects; Memory Disorders - drug therapy; Memory Disorders - genetics; Memory Disorders - pathology; Mice; molecular biology; Molecular modelling; Morphology; Original Article; Oxidative stress; Oxidative Stress - drug effects; sericin; Sericins - pharmacology; silkworms; Social behavior; Social interaction; Tumor necrosis factor-α; Oxidative stress; Memory; Aging; Sericin; Sociability; Inflammation; Apoptosis

Sericin is a protein derived from silkworm cocoons and identified as an anti-aging agent. This study aimed to examine the effects of sericin administration on episodic and avoidance memories, social interaction behavior, and molecular mechanisms including oxidative stress, inflammation, and apoptosi...