Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer

• Published in: Biomedicine & pharmacotherapy Vol. 145; p. 112343
• Main Authors: Hang, Zhongci, Lei, Tong, Zeng, Zehua, Cai, Shanglin, Bi, Wangyu, Du, Hongwu
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.01.2022
• Subjects: Alzheimer Disease - epidemiology; Alzheimer Disease - microbiology; Alzheimer's disease; Animals; Cancer; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Humans; Intestinal flora; Neoplasms - epidemiology; Neoplasms - microbiology; Parkinson Disease - epidemiology; Parkinson Disease - microbiology; Parkinson's disease; Risk; ADNI; Parkinson's disease; ALS; PVN; DOCA; AHR; IL-22; PBC; Aβ; IFN-γ; TRP; mTOR; Alzheimer's disease; AD; MAPK; IL-8; IL-1β; SCFA; IL-6; IL-10; BACE1; RC; PDAC; CRC; ND; CRF; ROS; Intestinal flora; PD-1; NK; TH17; TMAO; Fecal microbiota transplantation; T cells; NTS; LPS; HPV; CBS; Nrf2; Fra-1; TGF-β; GC; IL-17 F; CC; CD; GIST; GLP-1; IL-17A; Tregs; CCK; H3; FMT; PAD; PD; TNF-α; TNF-β; LC; PIN1; HD; ATP; DC; Cancer

An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to e...