Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer

An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to e...

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Published inBiomedicine & pharmacotherapy Vol. 145; p. 112343
Main Authors Hang, Zhongci, Lei, Tong, Zeng, Zehua, Cai, Shanglin, Bi, Wangyu, Du, Hongwu
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.01.2022
Subjects
Alzheimer Disease - epidemiology
Alzheimer Disease - microbiology
Alzheimer's disease
Animals
Cancer
Fecal Microbiota Transplantation
Gastrointestinal Microbiome
Humans
Intestinal flora
Neoplasms - epidemiology
Neoplasms - microbiology
Parkinson Disease - epidemiology
Parkinson Disease - microbiology
Parkinson's disease
Risk
ADNI
Parkinson's disease
ALS
PVN
DOCA
AHR
IL-22
PBC
Aβ
IFN-γ
TRP
mTOR
Alzheimer's disease
AD
MAPK
IL-8
IL-1β
SCFA
IL-6
IL-10
BACE1
RC
PDAC
CRC
ND
CRF
ROS
Intestinal flora
PD-1
NK
TH17
TMAO
Fecal microbiota transplantation
T cells
NTS
LPS
HPV
CBS
Nrf2
Fra-1
TGF-β
GC
IL-17 F
CC
CD
GIST
GLP-1
IL-17A
Tregs
CCK
H3
FMT
PAD
PD
TNF-α
TNF-β
LC
PIN1
HD
ATP
DC
Cancer
Online AccessGet full text

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Abstract An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barriers and intestinal hormones in AD/PD and cancer. After screening, a part of the flora capable of participating in the occurrence processes of the three diseases at the same time was obtained, the abundance changes of the special flora in AD/PD and various types of cancers were summarized, and they were classified according to the flora function and abundance, which in turn innovatively and reasonably explained the fact that AD/PD and cancer showed certain antagonism in epidemiological statistics from the perspective of intestinal flora. This review also proposed that viewing the risk relationship between diseases from the perspective of intestinal flora may provide new research ideas for the treatment of fecal microbiota transplantation (FMT) and related diseases. [Display omitted] •The relationship between AD/PD and cancer risk is antagonistic.•Both AD/PD and cancer have bidirectional connection with intestinal flora.•Some intestinal flora and its metabolites play different roles in AD/PD and cancer.•Intestinal barriers and gut hormone are involved in the regulation of diseases.•Changes of intestinal flora may be a factor affecting the disease risk relationship.
AbstractList An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barriers and intestinal hormones in AD/PD and cancer. After screening, a part of the flora capable of participating in the occurrence processes of the three diseases at the same time was obtained, the abundance changes of the special flora in AD/PD and various types of cancers were summarized, and they were classified according to the flora function and abundance, which in turn innovatively and reasonably explained the fact that AD/PD and cancer showed certain antagonism in epidemiological statistics from the perspective of intestinal flora. This review also proposed that viewing the risk relationship between diseases from the perspective of intestinal flora may provide new research ideas for the treatment of fecal microbiota transplantation (FMT) and related diseases.An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barriers and intestinal hormones in AD/PD and cancer. After screening, a part of the flora capable of participating in the occurrence processes of the three diseases at the same time was obtained, the abundance changes of the special flora in AD/PD and various types of cancers were summarized, and they were classified according to the flora function and abundance, which in turn innovatively and reasonably explained the fact that AD/PD and cancer showed certain antagonism in epidemiological statistics from the perspective of intestinal flora. This review also proposed that viewing the risk relationship between diseases from the perspective of intestinal flora may provide new research ideas for the treatment of fecal microbiota transplantation (FMT) and related diseases.
An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barriers and intestinal hormones in AD/PD and cancer. After screening, a part of the flora capable of participating in the occurrence processes of the three diseases at the same time was obtained, the abundance changes of the special flora in AD/PD and various types of cancers were summarized, and they were classified according to the flora function and abundance, which in turn innovatively and reasonably explained the fact that AD/PD and cancer showed certain antagonism in epidemiological statistics from the perspective of intestinal flora. This review also proposed that viewing the risk relationship between diseases from the perspective of intestinal flora may provide new research ideas for the treatment of fecal microbiota transplantation (FMT) and related diseases. [Display omitted] •The relationship between AD/PD and cancer risk is antagonistic.•Both AD/PD and cancer have bidirectional connection with intestinal flora.•Some intestinal flora and its metabolites play different roles in AD/PD and cancer.•Intestinal barriers and gut hormone are involved in the regulation of diseases.•Changes of intestinal flora may be a factor affecting the disease risk relationship.
An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barriers and intestinal hormones in AD/PD and cancer. After screening, a part of the flora capable of participating in the occurrence processes of the three diseases at the same time was obtained, the abundance changes of the special flora in AD/PD and various types of cancers were summarized, and they were classified according to the flora function and abundance, which in turn innovatively and reasonably explained the fact that AD/PD and cancer showed certain antagonism in epidemiological statistics from the perspective of intestinal flora. This review also proposed that viewing the risk relationship between diseases from the perspective of intestinal flora may provide new research ideas for the treatment of fecal microbiota transplantation (FMT) and related diseases.
ArticleNumber 112343
Author Cai, Shanglin
Bi, Wangyu
Zeng, Zehua
Du, Hongwu
Lei, Tong
Hang, Zhongci
Author_xml – sequence: 1
  givenname: Zhongci
  surname: Hang
  fullname: Hang, Zhongci
  organization: Daxing Research Institute, University of Science and Technology Beijing, China
– sequence: 2
  givenname: Tong
  surname: Lei
  fullname: Lei, Tong
  organization: Daxing Research Institute, University of Science and Technology Beijing, China
– sequence: 3
  givenname: Zehua
  surname: Zeng
  fullname: Zeng, Zehua
  organization: School of Chemistry and Biological Engineering, University of Science and Technology Beijing, China
– sequence: 4
  givenname: Shanglin
  surname: Cai
  fullname: Cai, Shanglin
  organization: Daxing Research Institute, University of Science and Technology Beijing, China
– sequence: 5
  givenname: Wangyu
  surname: Bi
  fullname: Bi, Wangyu
  organization: Daxing Research Institute, University of Science and Technology Beijing, China
– sequence: 6
  givenname: Hongwu
  surname: Du
  fullname: Du, Hongwu
  email: hongwudu@ustb.edu.cn
  organization: Daxing Research Institute, University of Science and Technology Beijing, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34864312$$D View this record in MEDLINE/PubMed
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Keywords ADNI
Parkinson's disease
ALS
PVN
DOCA
AHR
IL-22
PBC
Aβ
IFN-γ
TRP
mTOR
Alzheimer's disease
AD
MAPK
IL-8
IL-1β
SCFA
IL-6
IL-10
BACE1
RC
PDAC
CRC
ND
CRF
ROS
Intestinal flora
PD-1
NK
TH17
TMAO
Fecal microbiota transplantation
T cells
NTS
LPS
HPV
CBS
Nrf2
Fra-1
TGF-β
GC
IL-17 F
CC
CD
GIST
GLP-1
IL-17A
Tregs
CCK
H3
FMT
PAD
PD
TNF-α
TNF-β
LC
PIN1
HD
ATP
DC
Cancer
Language English
License This is an open access article under the CC BY-NC-ND license.
Copyright © 2021. Published by Elsevier Masson SAS.
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Snippet An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's...
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SubjectTerms Alzheimer Disease - epidemiology
Alzheimer Disease - microbiology
Alzheimer's disease
Animals
Cancer
Fecal Microbiota Transplantation
Gastrointestinal Microbiome
Humans
Intestinal flora
Neoplasms - epidemiology
Neoplasms - microbiology
Parkinson Disease - epidemiology
Parkinson Disease - microbiology
Parkinson's disease
Risk
Title Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer
URI https://dx.doi.org/10.1016/j.biopha.2021.112343
https://www.ncbi.nlm.nih.gov/pubmed/34864312
https://www.proquest.com/docview/2607308918
Volume 145
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