Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis

• Published in: Nucleic acids research Vol. 46; no. 17; pp. 8832 - 8847
• Main Authors: Lee, Ying-Ying, Mok, Myth TS, Kang, Wei, Yang, Weiqin, Tang, Wenshu, Wu, Feng, Xu, Liangliang, Yan, Mingfei, Yu, Zhuo, Lee, Sau-Dan, Tong, Joanna H M, Cheung, Yue-Sun, Lai, Paul B S, Yu, Dae-Yeul, Wang, Qianben, Wong, Grace L H, Chan, Andrew M, Yip, Kevin Y, To, Ka-Fai, Cheng, Alfred S L
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 28.09.2018
• Subjects: Gene regulation, Chromatin and Epigenetics

Abstract Genomic sequencing of hepatocellular carcinoma (HCC) uncovers a paucity of actionable mutations, underscoring the necessity to exploit epigenetic vulnerabilities for therapeutics. In HCC, EZH2-mediated H3K27me3 represents a major oncogenic chromatin modification, but how it modulates the th...