Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance

• Published in: Cell reports (Cambridge) Vol. 33; no. 4; p. 108317
• Main Authors: DeSouza-Vieira, Thiago, Iniguez, Eva, Serafim, Tiago D., de Castro, Waldionê, Karmakar, Subir, Disotuar, Maria M., Cecilio, Pedro, Lacsina, Joshua R., Meneses, Claudio, Nagata, Bianca M., Cardoso, Silvia, Sonenshine, Daniel E., Moore, Ian N., Borges, Valeria M., Dey, Ranadhir, Soares, Miguel P., Nakhasi, Hira L., Oliveira, Fabiano, Valenzuela, Jesus G., Kamhawi, Shaden
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.10.2020
• Subjects: disease tolerance; erythrophagocytosis; hematophagous arthropods; heme oxygenase-1; inflammation; Leishmania; mosquitoes and ticks; red blood cells; sand fly; vector-borne disease; red blood cells; inflammation; Leishmania; disease tolerance; mosquitoes and ticks; hematophagous arthropods; erythrophagocytosis; heme oxygenase-1; vector-borne disease; sand fly

Hematophagous vectors lacerate host skin and capillaries to acquire a blood meal, resulting in leakage of red blood cells (RBCs) and inflammation. Here, we show that heme oxygenase-1 (HO-1), a pleiotropic cytoprotective isoenzyme that mitigates heme-mediated tissue damage, is induced after bites of...