mTOR in podocyte function Is rapamycin good for diabetic nephropathy?

• Published in: Cell cycle (Georgetown, Tex.) Vol. 10; no. 20; pp. 3415 - 3416
• Main Authors: Lu, Min-Kan, Gong, Xing-Guo, Guan, Kun-Liang
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 15.10.2011; Landes Bioscience
• Subjects: Animals; Binding; Biology; Bioscience; Calcium; Cancer; Cell; Cycle; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - metabolism; Landes; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Knockout; Monomeric GTP-Binding Proteins - metabolism; Multiprotein Complexes; Neuropeptides - metabolism; Organogenesis; Podocytes - metabolism; Podocytes - physiology; Proteins; Proteins - antagonists & inhibitors; Proteins - metabolism; Ras Homolog Enriched in Brain Protein; Signal Transduction - physiology; Sirolimus - pharmacology; Sirolimus - therapeutic use; TOR Serine-Threonine Kinases - metabolism; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism

Comment on: Inoki K, et al. J Clin Invest 2011; 121:2181-2196 and Gödel M, et al. J Clin Invest 2011; 121:2197-2209