Activated clotting factor X mediates mitochondrial alterations and inflammatory responses via protease-activated receptor signaling in alveolar epithelial cells
There is growing evidence for the contribution of the activated coagulation factor X (FXa) in the development of chronic inflammatory lung diseases. Therefore, we aimed to investigate effects of exogenous FXa on mitochondrial and metabolic function as well as the induction of inflammatory molecules...
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Published in | European journal of pharmacology Vol. 869; p. 172875 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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15.02.2020
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Abstract | There is growing evidence for the contribution of the activated coagulation factor X (FXa) in the development of chronic inflammatory lung diseases. Therefore, we aimed to investigate effects of exogenous FXa on mitochondrial and metabolic function as well as the induction of inflammatory molecules in type II alveolar epithelial cells. Effects of FXa on epithelial cells were investigated in A549 cell line. Activation of extracellular signal-regulated kinase (ERK) and induction of inflammatory molecules were examined by immunoblot and gene expression analysis. Mitochondrial function was assessed by the measurement of oxygen consumption during maximal oxidative phosphorylation and quantitative determination of cardiolipin oxidation. Apoptosis was tested using a caspase 3 antibody. Metabolic activity and lactate dehydrogenase assay were applied for the detection of cellular viability.
FXa activated ERK1/2 and induced an increase in the expression of pro-inflammatory cytokines, which was prevented by an inhibitor of FXa, edoxaban, or an inhibitor of protease-activated receptor 1, vorapaxar. Exposure to FXa caused mitochondrial alteration with restricted capacity for ATP generation, which was effectively prevented by edoxaban, vorapaxar and GB83 (inhibitor of protease-activated receptor 2). Of note, exposure to FXa did not initiate apoptosis in epithelial cells.
FXa-dependent pro-inflammatory state and impairment of mitochondria did not reach the level of significance in lung epithelial cells. However, these effects might limit regenerative potency of lung epithelial cells, particular under clinical circumstances where lung injury causes exposure to clotting factors. |
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AbstractList | There is growing evidence for the contribution of the activated coagulation factor X (FXa) in the development of chronic inflammatory lung diseases. Therefore, we aimed to investigate effects of exogenous FXa on mitochondrial and metabolic function as well as the induction of inflammatory molecules in type II alveolar epithelial cells. Effects of FXa on epithelial cells were investigated in A549 cell line. Activation of extracellular signal-regulated kinase (ERK) and induction of inflammatory molecules were examined by immunoblot and gene expression analysis. Mitochondrial function was assessed by the measurement of oxygen consumption during maximal oxidative phosphorylation and quantitative determination of cardiolipin oxidation. Apoptosis was tested using a caspase 3 antibody. Metabolic activity and lactate dehydrogenase assay were applied for the detection of cellular viability. FXa activated ERK1/2 and induced an increase in the expression of pro-inflammatory cytokines, which was prevented by an inhibitor of FXa, edoxaban, or an inhibitor of protease-activated receptor 1, vorapaxar. Exposure to FXa caused mitochondrial alteration with restricted capacity for ATP generation, which was effectively prevented by edoxaban, vorapaxar and GB83 (inhibitor of protease-activated receptor 2). Of note, exposure to FXa did not initiate apoptosis in epithelial cells. FXa-dependent pro-inflammatory state and impairment of mitochondria did not reach the level of significance in lung epithelial cells. However, these effects might limit regenerative potency of lung epithelial cells, particular under clinical circumstances where lung injury causes exposure to clotting factors. There is growing evidence for the contribution of the activated coagulation factor X (FXa) in the development of chronic inflammatory lung diseases. Therefore, we aimed to investigate effects of exogenous FXa on mitochondrial and metabolic function as well as the induction of inflammatory molecules in type II alveolar epithelial cells. Effects of FXa on epithelial cells were investigated in A549 cell line. Activation of extracellular signal-regulated kinase (ERK) and induction of inflammatory molecules were examined by immunoblot and gene expression analysis. Mitochondrial function was assessed by the measurement of oxygen consumption during maximal oxidative phosphorylation and quantitative determination of cardiolipin oxidation. Apoptosis was tested using a caspase 3 antibody. Metabolic activity and lactate dehydrogenase assay were applied for the detection of cellular viability. FXa activated ERK1/2 and induced an increase in the expression of pro-inflammatory cytokines, which was prevented by an inhibitor of FXa, edoxaban, or an inhibitor of protease-activated receptor 1, vorapaxar. Exposure to FXa caused mitochondrial alteration with restricted capacity for ATP generation, which was effectively prevented by edoxaban, vorapaxar and GB83 (inhibitor of protease-activated receptor 2). Of note, exposure to FXa did not initiate apoptosis in epithelial cells. FXa-dependent pro-inflammatory state and impairment of mitochondria did not reach the level of significance in lung epithelial cells. However, these effects might limit regenerative potency of lung epithelial cells, particular under clinical circumstances where lung injury causes exposure to clotting factors. |
ArticleNumber | 172875 |
Author | Wiese-Rischke, Cornelia Walles, Thorsten Bukowska, Alicja Peter, Daniela Gardemann, Andreas Isermann, Berend Goette, Andreas Schild, Lorenz Bornfleth, Philipp |
Author_xml | – sequence: 1 givenname: Alicja surname: Bukowska fullname: Bukowska, Alicja email: alicja.bukowska@med.ovgu.de organization: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Magdeburg, Germany – sequence: 2 givenname: Lorenz surname: Schild fullname: Schild, Lorenz organization: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Magdeburg, Germany – sequence: 3 givenname: Philipp surname: Bornfleth fullname: Bornfleth, Philipp organization: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Magdeburg, Germany – sequence: 4 givenname: Daniela surname: Peter fullname: Peter, Daniela organization: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Magdeburg, Germany – sequence: 5 givenname: Cornelia surname: Wiese-Rischke fullname: Wiese-Rischke, Cornelia organization: Department of Thoracic Surgery, Otto-von-Guericke University Magdeburg, Germany – sequence: 6 givenname: Andreas surname: Gardemann fullname: Gardemann, Andreas organization: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Magdeburg, Germany – sequence: 7 givenname: Berend surname: Isermann fullname: Isermann, Berend organization: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Magdeburg, Germany – sequence: 8 givenname: Thorsten surname: Walles fullname: Walles, Thorsten organization: Department of Thoracic Surgery, Otto-von-Guericke University Magdeburg, Germany – sequence: 9 givenname: Andreas surname: Goette fullname: Goette, Andreas organization: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University Magdeburg, Germany |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31877279$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_3390_ijms232113653 crossref_primary_10_1007_s40264_020_00990_9 crossref_primary_10_3390_cells10112958 crossref_primary_10_1007_s00399_023_00944_5 crossref_primary_10_1016_j_cbi_2020_109223 crossref_primary_10_1055_s_0040_1716717 crossref_primary_10_3390_cells10102605 crossref_primary_10_1007_s10557_020_06999_7 crossref_primary_10_1016_j_jacep_2023_01_016 crossref_primary_10_1371_journal_pone_0292628 |
Cites_doi | 10.1111/jth.13721 10.1124/jpet.111.187062 10.2174/138161211795049813 10.5482/ha-1162 10.1016/j.yexcr.2007.04.014 10.1016/j.ejphar.2013.09.006 10.1172/JCI81113 10.1111/j.1476-5381.2011.01610.x 10.1016/j.ejcb.2006.12.003 10.1016/0003-2697(66)90172-2 10.4049/jimmunol.168.7.3577 10.1161/01.RES.0000111805.09592.D8 10.1164/rccm.201612-2480OC 10.1111/bph.12757 10.2353/ajpath.2008.070347 10.1016/j.pharmthera.2011.01.003 10.1136/thoraxjnl-2013-203740 10.1172/JCI74942 10.1021/jm100984y 10.1378/chest.128.3.1475 10.1016/j.jss.2010.01.041 10.1182/blood.V95.10.3133 10.1160/TH13-11-0967 10.1183/09031936.00060708 10.1038/nm.4447 10.1042/bst0300211 10.1007/s11010-014-2087-2 10.1038/nrneph.2015.177 10.1161/CIRCRESAHA.107.167759 10.1378/chest.127.1.266 10.1016/j.ijrobp.2007.03.043 10.1164/rccm.200308-1156OC 10.1111/j.1476-5381.2009.00449.x 10.1165/rcmb.2014-0419OC 10.1152/ajplung.00137.2007 10.1073/pnas.1218667110 10.1016/j.pharmthera.2007.04.002 10.1172/JCI200419569 10.1016/j.biocel.2018.02.016 10.1111/jth.13494 10.1164/rccm.200810-1615OC 10.1046/j.1538-7836.2003.00363.x 10.1056/NEJMcibr1311045 10.1152/ajplung.00553.2016 10.1111/bph.12544 10.1002/art.24935 10.1016/j.molmed.2008.08.001 10.1016/j.phrs.2017.04.020 10.1111/bcp.12469 10.1111/jcmm.13855 10.1007/s10753-013-9706-z 10.1016/j.chemphyslip.2013.11.010 10.1097/MOH.0000000000000473 10.1016/S0002-9440(10)62525-4 10.1378/chest.130.1.302-a |
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Keywords | Human lung epithelial cells Mitochondrial dysfunction “Biased” effects of GB83 Activated clotting factor X Inflammatory signaling Protease-activated receptors Apoptosis |
Language | English |
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References | Ostrowska, Sokolova, Reiser (bib36) 2007; 293 Yu, Tzouvelekis, Wang, Herazo-Maya, Ibarra, Srivastava (bib58) 2018; 24 Shahzad, Isermann (bib47) 2011; 31 Bogatkevich, Ludwicka-Bradley, Silver (bib10) 2009; 60 Sokolova, Reiser (bib51) 2007; 115 Zain, Huang, Feng, Nierodzik, Li, Karpatkin (bib59) 2000; 95 López-Farré, Rodriguez-Sierra, Modrego, Segura, Martín-Palacios, Saiz (bib30) 2014; 8 Wolter, Schild, Bock, Hellwig, Gadi, Al-Dabet (bib57) 2016; 14 Cloonan, Choi (bib17) 2016; 126 Rauch, Millette, Kenagy, Daum, Clowes (bib39) 2004; 94 Schuliga (bib41) 2015 Borensztajn, Bijlsma, Groot, Brüggemann, Versteeg, Reitsma (bib11) 2007; 313 Kinder, Collard, King (bib25) 2006; 130 Schuliga, Jaffar, Berhan, Langenbach, Harris, Waters (bib43) 2017; 312 Huang, Lien, Lin, Jiang, Chen (bib21) 2017; 121 Schuliga, Pechkovsky, Read, Waters, Blokland, Reid (bib45) 2018; 22 Bargagli, Madioni, Bianchi, Refini, Cappelli, Rottoli (bib4) 2014; 37 Schuliga, Grainge, Westall, Knight (bib44) 2018; 97 McKeown, Richter, O'Kane, McAuley, Thickett (bib33) 2009; 33 Bhattacharjee, Ahamed, Pawlinski, Liu, Mackman, Ruf, Edgington (bib7) 2008; 102 Belikova, Jiang, Tyurina, Zhao, Epperly, Greenberger, Kagan (bib6) 2007; 69 Howell, Goldsack, Marshall, McAnulty, Starke, Purdy (bib19) 2001; 159 Lohman, Cotterell, Suen, Liu, Do, Vesey, Fairlie (bib29) 2012; 340 Plataki, Koutsopoulos, Darivianaki, Delides, Siafakas, Bouros (bib38) 2005; 127 Howell, Laurent, Chambers (bib20) 2002; 30 Hollenberg, Mihara, Polley, Suen, Han, Fairlie, Ramachandran (bib18) 2014; 171 Kubo, Nakayama, Yanai, Suzuki, Yamaya, Watanabe (bib27) 2005; 128 Wang, Yi, Zheng, He (bib55) 2007; 86 Lambrecht, Hammad (bib28) 2013; 369 Terada, Kelly, Jarjour (bib54) 2004 Adams, Ramachandran, Yau, Suen, Fairlie, Hollenberg, Hooper (bib1) 2011; 130 Barry, Suen, Le, Cotterell, Reid, Fairlie (bib5) 2010; 53 Peters, Henry (bib37) 2009; 158 Navaratnam, Fogarty, McKeever, Thompson, Jenkins, Johnson (bib35) 2014; 69 Isermann (bib22) 2017; 15 Moellering, Gruber (bib34) 1966; 17 Jiang, Wang, Tanaka, Levy, Guyton, Zhao (bib23) 2011; 169 Shi, Wang, Zhou, Ji, Wang, Tong (bib49) 2018; 10 Bock, Shahzad, Vergnolle, Isermann (bib9) 2014; 111 Suen, Barry, Lohman, Halili, Cotterell, Le, Fairlie (bib52) 2012; 165 Asokananthan, Graham, Fink, Knight, Bakker, McWilliam (bib2) 2002; 168 Ryu, Sun, Gulati, Herazo-Maya, Chen, Osafo-Addo (bib40) 2017; 196 Wagers, Norton, Rinaldi, Bates, Sobel, Irvin (bib56) 2004; 114 Kagan, Chu, Tyurina, Cheikhi, Bayir (bib24) 2014; 179 Bukowska, Zacharias, Weinert, Skopp, Hartmann (bib16) 2013; 718 Suen, Cotterell, Lohman, Lim, Han, Yau (bib53) 2014; 171 Borensztajn, von der Thüsen, Spek (bib14) 2011; 17 Martens, Keilhoff, Gardemann, Schild (bib32) 2014; 394 Sisson, Mendez, Choi, Subbotina, Courey, Cunningham (bib50) 2010; 181 Borensztajn, Stiekema, Nijmeijer, Reitsma, Peppelenbosch, Spek (bib13) 2008; 172 Borensztajn, Peppelenbosch, Spek (bib12) 2008; 14 Schuliga, Royce, Langenbach, Berhan, Harris, Keenan, Stewart (bib42) 2016; 54 Madhusudhan, Kerlin, Isermann (bib31) 2016; 12 Bock, Shahzad, Wang, Stoyanov, Wolter, Dong (bib8) 2013; 110 Shahzad, Kohli, Al-Dabet, Isermann (bib48) 2019; 26 Bueno, Lai, Romero, Brands, St Croix, Kamga (bib15) 2015; 125 Scotton, Krupiczojc, Koenigshoff, Mercer, Lee, Kaminski (bib46) 2009; 119 Bachli, Pech, Johnson, Johnson, Tuddenham, McVey (bib3) 2003; 1 Lambrecht (10.1016/j.ejphar.2019.172875_bib28) 2013; 369 Shahzad (10.1016/j.ejphar.2019.172875_bib47) 2011; 31 Sisson (10.1016/j.ejphar.2019.172875_bib50) 2010; 181 Bogatkevich (10.1016/j.ejphar.2019.172875_bib10) 2009; 60 Scotton (10.1016/j.ejphar.2019.172875_bib46) 2009; 119 Ryu (10.1016/j.ejphar.2019.172875_bib40) 2017; 196 Kinder (10.1016/j.ejphar.2019.172875_bib25) 2006; 130 Peters (10.1016/j.ejphar.2019.172875_bib37) 2009; 158 Martens (10.1016/j.ejphar.2019.172875_bib32) 2014; 394 Navaratnam (10.1016/j.ejphar.2019.172875_bib35) 2014; 69 Hollenberg (10.1016/j.ejphar.2019.172875_bib18) 2014; 171 Schuliga (10.1016/j.ejphar.2019.172875_bib42) 2016; 54 Kagan (10.1016/j.ejphar.2019.172875_bib24) 2014; 179 Schuliga (10.1016/j.ejphar.2019.172875_bib43) 2017; 312 Ostrowska (10.1016/j.ejphar.2019.172875_bib36) 2007; 293 Borensztajn (10.1016/j.ejphar.2019.172875_bib12) 2008; 14 López-Farré (10.1016/j.ejphar.2019.172875_bib30) 2014; 8 Terada (10.1016/j.ejphar.2019.172875_bib54) 2004 Rauch (10.1016/j.ejphar.2019.172875_bib39) 2004; 94 Suen (10.1016/j.ejphar.2019.172875_bib52) 2012; 165 Bock (10.1016/j.ejphar.2019.172875_bib8) 2013; 110 Shi (10.1016/j.ejphar.2019.172875_bib49) 2018; 10 Kubo (10.1016/j.ejphar.2019.172875_bib27) 2005; 128 Plataki (10.1016/j.ejphar.2019.172875_bib38) 2005; 127 Howell (10.1016/j.ejphar.2019.172875_bib19) 2001; 159 Huang (10.1016/j.ejphar.2019.172875_bib21) 2017; 121 Madhusudhan (10.1016/j.ejphar.2019.172875_bib31) 2016; 12 Moellering (10.1016/j.ejphar.2019.172875_bib34) 1966; 17 Lohman (10.1016/j.ejphar.2019.172875_bib29) 2012; 340 Suen (10.1016/j.ejphar.2019.172875_bib53) 2014; 171 Bargagli (10.1016/j.ejphar.2019.172875_bib4) 2014; 37 Bhattacharjee (10.1016/j.ejphar.2019.172875_bib7) 2008; 102 Jiang (10.1016/j.ejphar.2019.172875_bib23) 2011; 169 Schuliga (10.1016/j.ejphar.2019.172875_bib45) 2018; 22 Borensztajn (10.1016/j.ejphar.2019.172875_bib13) 2008; 172 Cloonan (10.1016/j.ejphar.2019.172875_bib17) 2016; 126 Belikova (10.1016/j.ejphar.2019.172875_bib6) 2007; 69 Schuliga (10.1016/j.ejphar.2019.172875_bib41) 2015 Zain (10.1016/j.ejphar.2019.172875_bib59) 2000; 95 Yu (10.1016/j.ejphar.2019.172875_bib58) 2018; 24 Sokolova (10.1016/j.ejphar.2019.172875_bib51) 2007; 115 Howell (10.1016/j.ejphar.2019.172875_bib20) 2002; 30 Wagers (10.1016/j.ejphar.2019.172875_bib56) 2004; 114 Bukowska (10.1016/j.ejphar.2019.172875_bib16) 2013; 718 Adams (10.1016/j.ejphar.2019.172875_bib1) 2011; 130 Bueno (10.1016/j.ejphar.2019.172875_bib15) 2015; 125 Borensztajn (10.1016/j.ejphar.2019.172875_bib11) 2007; 313 Bachli (10.1016/j.ejphar.2019.172875_bib3) 2003; 1 Wolter (10.1016/j.ejphar.2019.172875_bib57) 2016; 14 Schuliga (10.1016/j.ejphar.2019.172875_bib44) 2018; 97 Shahzad (10.1016/j.ejphar.2019.172875_bib48) 2019; 26 Asokananthan (10.1016/j.ejphar.2019.172875_bib2) 2002; 168 McKeown (10.1016/j.ejphar.2019.172875_bib33) 2009; 33 Barry (10.1016/j.ejphar.2019.172875_bib5) 2010; 53 Borensztajn (10.1016/j.ejphar.2019.172875_bib14) 2011; 17 Bock (10.1016/j.ejphar.2019.172875_bib9) 2014; 111 Isermann (10.1016/j.ejphar.2019.172875_bib22) 2017; 15 Wang (10.1016/j.ejphar.2019.172875_bib55) 2007; 86 |
References_xml | – volume: 1 start-page: 1935 year: 2003 end-page: 1944 ident: bib3 article-title: Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts publication-title: J. Thromb. Haemost. contributor: fullname: McVey – start-page: 373 year: 2004 end-page: 377 ident: bib54 article-title: Increased thrombin activity after allergen challenge: a potential link to airway remodeling? publication-title: Am. J. Respir. Crit. Care Med. contributor: fullname: Jarjour – volume: 394 start-page: 119 year: 2014 end-page: 127 ident: bib32 article-title: Oxidation of cardiolipin is involved in functional impairment and disintegration of liver mitochondria by hypoxia/reoxygenation in the presence of increased Ca publication-title: Mol. Cell. Biochem. contributor: fullname: Schild – volume: 130 start-page: 248 year: 2011 end-page: 282 ident: bib1 article-title: Structure, function and pathophysiology of protease activated receptors publication-title: Pharmacol. Ther. contributor: fullname: Hooper – volume: 293 start-page: L1208 year: 2007 end-page: L1218 ident: bib36 article-title: PAR-2 activation and LPS synergistically enhance inflammatory signaling in airway epithelial cells by raising PAR expression level and interleukin-8 release publication-title: Am. J. Physiol. Lung Cell Mol. Physiol. contributor: fullname: Reiser – volume: 127 start-page: 266 year: 2005 end-page: 274 ident: bib38 article-title: Expression of apoptotic and antiapoptotic markers in epithelial cells in idiopathic pulmonary fibrosis publication-title: Chest contributor: fullname: Bouros – volume: 119 start-page: 2550 year: 2009 end-page: 2563 ident: bib46 article-title: Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury publication-title: J. Clin. Investig. contributor: fullname: Kaminski – volume: 159 start-page: 1383 year: 2001 end-page: 1395 ident: bib19 article-title: Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis publication-title: Am. J. Pathol. contributor: fullname: Purdy – volume: 114 start-page: 104 year: 2004 end-page: 111 ident: bib56 article-title: Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness publication-title: J. Clin. Investig. contributor: fullname: Irvin – volume: 110 start-page: 648 year: 2013 end-page: 653 ident: bib8 article-title: Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Dong – volume: 102 start-page: 457 year: 2008 end-page: 464 ident: bib7 article-title: Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1 publication-title: Circ. Res. contributor: fullname: Edgington – volume: 171 start-page: 1180 year: 2014 end-page: 1194 ident: bib18 article-title: Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease publication-title: Br. J. Pharmacol. contributor: fullname: Ramachandran – volume: 69 start-page: 207 year: 2014 end-page: 215 ident: bib35 article-title: Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case-control study publication-title: Thorax contributor: fullname: Johnson – volume: 54 start-page: 200 year: 2016 end-page: 209 ident: bib42 article-title: The coagulant factor xa induces protease-activated receptor-1 and annexin A2-dependent airway smooth muscle cytokine production and cell proliferation publication-title: Am. J. Respir. Cell Mol. Biol. contributor: fullname: Stewart – volume: 111 start-page: 610 year: 2014 end-page: 617 ident: bib9 article-title: Activated protein C based therapeutic strategies in chronic diseases publication-title: Thromb. Haemost. contributor: fullname: Isermann – start-page: 437695 year: 2015 ident: bib41 article-title: The inflammatory actions of coagulant and fibrinolytic proteases in disease publication-title: Mediat. Inflamm. contributor: fullname: Schuliga – volume: 165 start-page: 1413 year: 2012 end-page: 1423 ident: bib52 article-title: Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110) publication-title: Br. J. Pharmacol. contributor: fullname: Fairlie – volume: 17 start-page: 9 year: 2011 end-page: 16 ident: bib14 article-title: The role of coagulation in chronic inflammatory disorders: a jack of all trades publication-title: Curr. Pharmacogenomics contributor: fullname: Spek – volume: 168 start-page: 3577 year: 2002 end-page: 3585 ident: bib2 article-title: Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells publication-title: J. Immunol. contributor: fullname: McWilliam – volume: 86 start-page: 233 year: 2007 end-page: 242 ident: bib55 article-title: Induction of monocyte chemoattractant protein-1 release from A549 cells by agonists of protease-activated receptor-1 and -2 publication-title: Eur. J. Cell Biol. contributor: fullname: He – volume: 369 start-page: 1964 year: 2013 end-page: 1966 ident: bib28 article-title: Asthma and coagulation publication-title: N. Engl. J. Med. contributor: fullname: Hammad – volume: 115 start-page: 70 year: 2007 end-page: 83 ident: bib51 article-title: A novel therapeutic target in various lung diseases: airway proteases and protease-activated receptors publication-title: Pharmacol. Ther. contributor: fullname: Reiser – volume: 14 start-page: 429 year: 2008 end-page: 440 ident: bib12 article-title: Factor Xa: at the crossroads between coagulation and signaling in physiology and disease publication-title: Trends Mol. Med. contributor: fullname: Spek – volume: 130 start-page: 302 year: 2006 end-page: 303 ident: bib25 article-title: Anticoagulant therapy and idiopathic pulmonary fibrosis publication-title: Chest contributor: fullname: King – volume: 181 start-page: 254 year: 2010 end-page: 263 ident: bib50 article-title: Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis publication-title: Am. J. Respir. Crit. Care Med. contributor: fullname: Cunningham – volume: 14 start-page: 2122 year: 2016 end-page: 2226 ident: bib57 article-title: Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system publication-title: J. Thromb. Haemost. contributor: fullname: Al-Dabet – volume: 95 start-page: 3133 year: 2000 end-page: 3138 ident: bib59 article-title: Concentration-dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells publication-title: Blood contributor: fullname: Karpatkin – volume: 94 start-page: 340 year: 2004 end-page: 345 ident: bib39 article-title: Thrombin- and factorXa-induced DNA synthesis is mediated by transactivation of fibroblast growthfactor receptor-1 in human vascular smooth muscle cells publication-title: Circ. Res. contributor: fullname: Clowes – volume: 125 start-page: 521 year: 2015 end-page: 538 ident: bib15 article-title: PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis publication-title: J. Clin. Investig. contributor: fullname: Kamga – volume: 8 start-page: 1366 year: 2014 end-page: 1377 ident: bib30 article-title: Effects of factor Xa on the expression of proteins in femoral arteries from type 2 diabetic patients publication-title: Br. J. Clin. Pharmacol. contributor: fullname: Saiz – volume: 12 start-page: 94 year: 2016 end-page: 109 ident: bib31 article-title: The emerging role of coagulation proteases in kidney disease publication-title: Nat. Rev. Nephrol. contributor: fullname: Isermann – volume: 171 start-page: 4112 year: 2014 end-page: 4124 ident: bib53 article-title: Pathway-selective antagonism of proteinase activated receptor 2 publication-title: Br. J. Pharmacol. contributor: fullname: Yau – volume: 121 start-page: 33 year: 2017 end-page: 41 ident: bib21 article-title: p300 and C/EBPβ-regulated IKKβ expression are involved in thrombin-induced IL-8/CXCL8 expression in human lung epithelial cells publication-title: Pharmacol. Res. contributor: fullname: Chen – volume: 33 start-page: 77 year: 2009 end-page: 84 ident: bib33 article-title: MMP expression and abnormal lung permeability are important determinants of outcome in IPF publication-title: Eur. Respir. J. contributor: fullname: Thickett – volume: 26 start-page: 41 year: 2019 end-page: 50 ident: bib48 article-title: Cell biology of activated protein C publication-title: Curr. Opin. Hematol. contributor: fullname: Isermann – volume: 179 start-page: 64 year: 2014 end-page: 69 ident: bib24 article-title: Cardiolipin asymmetry, oxidation and signaling publication-title: Chem. Phys. Lipids contributor: fullname: Bayir – volume: 718 start-page: 114 year: 2013 end-page: 123 ident: bib16 article-title: Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue publication-title: Eur. J. Pharmacol. contributor: fullname: Hartmann – volume: 172 start-page: 309 year: 2008 end-page: 320 ident: bib13 article-title: Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation publication-title: Am. J. Pathol. contributor: fullname: Spek – volume: 158 start-page: 1017 year: 2009 end-page: 1033 ident: bib37 article-title: Protease-activated receptors and prostaglandins in inflammatory lung disease publication-title: Br. J. Pharmacol. contributor: fullname: Henry – volume: 313 start-page: 2622 year: 2007 end-page: 2633 ident: bib11 article-title: Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation publication-title: Exp. Cell Res. contributor: fullname: Reitsma – volume: 69 start-page: 176 year: 2007 end-page: 186 ident: bib6 article-title: Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis publication-title: Int. J. Radiat. Oncol. Biol. Phys. contributor: fullname: Kagan – volume: 15 start-page: 1273 year: 2017 end-page: 1284 ident: bib22 article-title: Homeostatic effects of coagulation protease-dependent signalling and protease activated receptors publication-title: J. Thromb. Haemost. contributor: fullname: Isermann – volume: 24 start-page: 39 year: 2018 end-page: 49 ident: bib58 article-title: Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function publication-title: Nat. Med. contributor: fullname: Srivastava – volume: 97 start-page: 108 year: 2018 end-page: 117 ident: bib44 article-title: The fibrogenic actions of the coagulant and plasminogen activation systems in pulmonary fibrosis publication-title: Int. J. Biochem. Cell Biol. contributor: fullname: Knight – volume: 37 start-page: 10 year: 2014 end-page: 16 ident: bib4 article-title: Serum analysis of coagulation factors in IPF and NSIP publication-title: Inflammation contributor: fullname: Rottoli – volume: 169 start-page: 319 year: 2011 end-page: 327 ident: bib23 article-title: Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-κB-dependent pathways publication-title: J. Surg. Res. contributor: fullname: Zhao – volume: 126 start-page: 809 year: 2016 end-page: 820 ident: bib17 article-title: Mitochondria in lung disease publication-title: J. Clin. Investig. contributor: fullname: Choi – volume: 196 start-page: 1571 year: 2017 end-page: 1581 ident: bib40 article-title: Extracellular mitochondrial DNA is generated by fibroblasts and predicts death in idiopathic pulmonary fibrosis publication-title: Am. J. Respir. Crit. Care Med. contributor: fullname: Osafo-Addo – volume: 17 start-page: 369 year: 1966 end-page: 376 ident: bib34 article-title: Determination of citrate with citrate lyase publication-title: Anal. Biochem. contributor: fullname: Gruber – volume: 30 start-page: 211 year: 2002 end-page: 216 ident: bib20 article-title: Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis publication-title: Biochem. Soc. Trans. contributor: fullname: Chambers – volume: 340 start-page: 256 year: 2012 end-page: 265 ident: bib29 article-title: Antagonism of protease-activated receptor 2 protects against experimental colitis publication-title: J. Pharmacol. Exp. Ther. contributor: fullname: Fairlie – volume: 31 start-page: 179 year: 2011 end-page: 184 ident: bib47 article-title: The evolving plasticity of coagulation protease-dependent cytoprotective signalling publication-title: Hämostaseologie contributor: fullname: Isermann – volume: 22 start-page: 5847 year: 2018 end-page: 5861 ident: bib45 article-title: Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts publication-title: J. Cell Mol. Med. contributor: fullname: Reid – volume: 60 start-page: 3455 year: 2009 end-page: 3464 ident: bib10 article-title: Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts publication-title: Arthritis Rheum. contributor: fullname: Silver – volume: 128 start-page: 1475 year: 2005 end-page: 1482 ident: bib27 article-title: Anticoagulant therapy for idiopathic pulmonary fibrosis publication-title: Chest contributor: fullname: Watanabe – volume: 53 start-page: 7428 year: 2010 end-page: 7440 ident: bib5 article-title: Novel agonists and antagonists for human protease activated receptor 2 publication-title: J. Med. Chem. contributor: fullname: Fairlie – volume: 312 start-page: L772 year: 2017 end-page: L782 ident: bib43 article-title: Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity publication-title: Am. J. Physiol. Lung Cell Mol. Physiol. contributor: fullname: Waters – volume: 10 start-page: 2335 year: 2018 end-page: 2349 ident: bib49 article-title: Direct factor Xa inhibition attenuates acute lung injury progression via modulation of the PAR-2/NF-κB signaling pathway publication-title: Am. J. Trans. Res. contributor: fullname: Tong – volume: 15 start-page: 1273 issue: 7 year: 2017 ident: 10.1016/j.ejphar.2019.172875_bib22 article-title: Homeostatic effects of coagulation protease-dependent signalling and protease activated receptors publication-title: J. Thromb. Haemost. doi: 10.1111/jth.13721 contributor: fullname: Isermann – volume: 340 start-page: 256 issue: 2 year: 2012 ident: 10.1016/j.ejphar.2019.172875_bib29 article-title: Antagonism of protease-activated receptor 2 protects against experimental colitis publication-title: J. Pharmacol. Exp. Ther. doi: 10.1124/jpet.111.187062 contributor: fullname: Lohman – volume: 17 start-page: 9 issue: 1 year: 2011 ident: 10.1016/j.ejphar.2019.172875_bib14 article-title: The role of coagulation in chronic inflammatory disorders: a jack of all trades publication-title: Curr. Pharmacogenomics doi: 10.2174/138161211795049813 contributor: fullname: Borensztajn – volume: 31 start-page: 179 issue: 3 year: 2011 ident: 10.1016/j.ejphar.2019.172875_bib47 article-title: The evolving plasticity of coagulation protease-dependent cytoprotective signalling publication-title: Hämostaseologie doi: 10.5482/ha-1162 contributor: fullname: Shahzad – volume: 313 start-page: 2622 issue: 12 year: 2007 ident: 10.1016/j.ejphar.2019.172875_bib11 article-title: Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2007.04.014 contributor: fullname: Borensztajn – volume: 718 start-page: 114 issue: 1–3 year: 2013 ident: 10.1016/j.ejphar.2019.172875_bib16 article-title: Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2013.09.006 contributor: fullname: Bukowska – volume: 126 start-page: 809 issue: 3 year: 2016 ident: 10.1016/j.ejphar.2019.172875_bib17 article-title: Mitochondria in lung disease publication-title: J. Clin. Investig. doi: 10.1172/JCI81113 contributor: fullname: Cloonan – volume: 165 start-page: 1413 year: 2012 ident: 10.1016/j.ejphar.2019.172875_bib52 article-title: Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110) publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2011.01610.x contributor: fullname: Suen – volume: 86 start-page: 233 issue: 4 year: 2007 ident: 10.1016/j.ejphar.2019.172875_bib55 article-title: Induction of monocyte chemoattractant protein-1 release from A549 cells by agonists of protease-activated receptor-1 and -2 publication-title: Eur. J. Cell Biol. doi: 10.1016/j.ejcb.2006.12.003 contributor: fullname: Wang – volume: 17 start-page: 369 year: 1966 ident: 10.1016/j.ejphar.2019.172875_bib34 article-title: Determination of citrate with citrate lyase publication-title: Anal. Biochem. doi: 10.1016/0003-2697(66)90172-2 contributor: fullname: Moellering – volume: 168 start-page: 3577 issue: 7 year: 2002 ident: 10.1016/j.ejphar.2019.172875_bib2 article-title: Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells publication-title: J. Immunol. doi: 10.4049/jimmunol.168.7.3577 contributor: fullname: Asokananthan – volume: 94 start-page: 340 issue: 3 year: 2004 ident: 10.1016/j.ejphar.2019.172875_bib39 article-title: Thrombin- and factorXa-induced DNA synthesis is mediated by transactivation of fibroblast growthfactor receptor-1 in human vascular smooth muscle cells publication-title: Circ. Res. doi: 10.1161/01.RES.0000111805.09592.D8 contributor: fullname: Rauch – volume: 10 start-page: 2335 issue: 8 year: 2018 ident: 10.1016/j.ejphar.2019.172875_bib49 article-title: Direct factor Xa inhibition attenuates acute lung injury progression via modulation of the PAR-2/NF-κB signaling pathway publication-title: Am. J. Trans. Res. contributor: fullname: Shi – volume: 196 start-page: 1571 issue: 12 year: 2017 ident: 10.1016/j.ejphar.2019.172875_bib40 article-title: Extracellular mitochondrial DNA is generated by fibroblasts and predicts death in idiopathic pulmonary fibrosis publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201612-2480OC contributor: fullname: Ryu – volume: 171 start-page: 4112 issue: 17 year: 2014 ident: 10.1016/j.ejphar.2019.172875_bib53 article-title: Pathway-selective antagonism of proteinase activated receptor 2 publication-title: Br. J. Pharmacol. doi: 10.1111/bph.12757 contributor: fullname: Suen – volume: 172 start-page: 309 issue: 2 year: 2008 ident: 10.1016/j.ejphar.2019.172875_bib13 article-title: Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease-activated receptor-2 activation publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2008.070347 contributor: fullname: Borensztajn – volume: 130 start-page: 248 issue: 3 year: 2011 ident: 10.1016/j.ejphar.2019.172875_bib1 article-title: Structure, function and pathophysiology of protease activated receptors publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2011.01.003 contributor: fullname: Adams – volume: 69 start-page: 207 issue: 3 year: 2014 ident: 10.1016/j.ejphar.2019.172875_bib35 article-title: Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case-control study publication-title: Thorax doi: 10.1136/thoraxjnl-2013-203740 contributor: fullname: Navaratnam – volume: 125 start-page: 521 issue: 2 year: 2015 ident: 10.1016/j.ejphar.2019.172875_bib15 article-title: PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis publication-title: J. Clin. Investig. doi: 10.1172/JCI74942 contributor: fullname: Bueno – volume: 53 start-page: 7428 year: 2010 ident: 10.1016/j.ejphar.2019.172875_bib5 article-title: Novel agonists and antagonists for human protease activated receptor 2 publication-title: J. Med. Chem. doi: 10.1021/jm100984y contributor: fullname: Barry – volume: 128 start-page: 1475 issue: 3 year: 2005 ident: 10.1016/j.ejphar.2019.172875_bib27 article-title: Anticoagulant therapy for idiopathic pulmonary fibrosis publication-title: Chest doi: 10.1378/chest.128.3.1475 contributor: fullname: Kubo – volume: 169 start-page: 319 issue: 2 year: 2011 ident: 10.1016/j.ejphar.2019.172875_bib23 article-title: Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-κB-dependent pathways publication-title: J. Surg. Res. doi: 10.1016/j.jss.2010.01.041 contributor: fullname: Jiang – volume: 95 start-page: 3133 year: 2000 ident: 10.1016/j.ejphar.2019.172875_bib59 article-title: Concentration-dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells publication-title: Blood doi: 10.1182/blood.V95.10.3133 contributor: fullname: Zain – volume: 111 start-page: 610 issue: 4 year: 2014 ident: 10.1016/j.ejphar.2019.172875_bib9 article-title: Activated protein C based therapeutic strategies in chronic diseases publication-title: Thromb. Haemost. doi: 10.1160/TH13-11-0967 contributor: fullname: Bock – volume: 33 start-page: 77 issue: 1 year: 2009 ident: 10.1016/j.ejphar.2019.172875_bib33 article-title: MMP expression and abnormal lung permeability are important determinants of outcome in IPF publication-title: Eur. Respir. J. doi: 10.1183/09031936.00060708 contributor: fullname: McKeown – volume: 24 start-page: 39 issue: 1 year: 2018 ident: 10.1016/j.ejphar.2019.172875_bib58 article-title: Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function publication-title: Nat. Med. doi: 10.1038/nm.4447 contributor: fullname: Yu – volume: 119 start-page: 2550 year: 2009 ident: 10.1016/j.ejphar.2019.172875_bib46 article-title: Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury publication-title: J. Clin. Investig. contributor: fullname: Scotton – volume: 30 start-page: 211 issue: 2 year: 2002 ident: 10.1016/j.ejphar.2019.172875_bib20 article-title: Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis publication-title: Biochem. Soc. Trans. doi: 10.1042/bst0300211 contributor: fullname: Howell – volume: 394 start-page: 119 issue: 1–2 year: 2014 ident: 10.1016/j.ejphar.2019.172875_bib32 article-title: Oxidation of cardiolipin is involved in functional impairment and disintegration of liver mitochondria by hypoxia/reoxygenation in the presence of increased Ca2⁺ concentrations publication-title: Mol. Cell. Biochem. doi: 10.1007/s11010-014-2087-2 contributor: fullname: Martens – volume: 12 start-page: 94 issue: 2 year: 2016 ident: 10.1016/j.ejphar.2019.172875_bib31 article-title: The emerging role of coagulation proteases in kidney disease publication-title: Nat. Rev. Nephrol. doi: 10.1038/nrneph.2015.177 contributor: fullname: Madhusudhan – volume: 102 start-page: 457 issue: 4 year: 2008 ident: 10.1016/j.ejphar.2019.172875_bib7 article-title: Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1 publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.107.167759 contributor: fullname: Bhattacharjee – volume: 127 start-page: 266 issue: 1 year: 2005 ident: 10.1016/j.ejphar.2019.172875_bib38 article-title: Expression of apoptotic and antiapoptotic markers in epithelial cells in idiopathic pulmonary fibrosis publication-title: Chest doi: 10.1378/chest.127.1.266 contributor: fullname: Plataki – volume: 69 start-page: 176 issue: 1 year: 2007 ident: 10.1016/j.ejphar.2019.172875_bib6 article-title: Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis publication-title: Int. J. Radiat. Oncol. Biol. Phys. doi: 10.1016/j.ijrobp.2007.03.043 contributor: fullname: Belikova – start-page: 373 issue: 3 year: 2004 ident: 10.1016/j.ejphar.2019.172875_bib54 article-title: Increased thrombin activity after allergen challenge: a potential link to airway remodeling? publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.200308-1156OC contributor: fullname: Terada – volume: 158 start-page: 1017 issue: 4 year: 2009 ident: 10.1016/j.ejphar.2019.172875_bib37 article-title: Protease-activated receptors and prostaglandins in inflammatory lung disease publication-title: Br. J. Pharmacol. doi: 10.1111/j.1476-5381.2009.00449.x contributor: fullname: Peters – volume: 54 start-page: 200 issue: 2 year: 2016 ident: 10.1016/j.ejphar.2019.172875_bib42 article-title: The coagulant factor xa induces protease-activated receptor-1 and annexin A2-dependent airway smooth muscle cytokine production and cell proliferation publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2014-0419OC contributor: fullname: Schuliga – volume: 293 start-page: L1208 issue: 5 year: 2007 ident: 10.1016/j.ejphar.2019.172875_bib36 article-title: PAR-2 activation and LPS synergistically enhance inflammatory signaling in airway epithelial cells by raising PAR expression level and interleukin-8 release publication-title: Am. J. Physiol. Lung Cell Mol. Physiol. doi: 10.1152/ajplung.00137.2007 contributor: fullname: Ostrowska – volume: 110 start-page: 648 issue: 2 year: 2013 ident: 10.1016/j.ejphar.2019.172875_bib8 article-title: Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1218667110 contributor: fullname: Bock – start-page: 437695 year: 2015 ident: 10.1016/j.ejphar.2019.172875_bib41 article-title: The inflammatory actions of coagulant and fibrinolytic proteases in disease publication-title: Mediat. Inflamm. contributor: fullname: Schuliga – volume: 115 start-page: 70 issue: 1 year: 2007 ident: 10.1016/j.ejphar.2019.172875_bib51 article-title: A novel therapeutic target in various lung diseases: airway proteases and protease-activated receptors publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2007.04.002 contributor: fullname: Sokolova – volume: 114 start-page: 104 issue: 1 year: 2004 ident: 10.1016/j.ejphar.2019.172875_bib56 article-title: Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness publication-title: J. Clin. Investig. doi: 10.1172/JCI200419569 contributor: fullname: Wagers – volume: 97 start-page: 108 year: 2018 ident: 10.1016/j.ejphar.2019.172875_bib44 article-title: The fibrogenic actions of the coagulant and plasminogen activation systems in pulmonary fibrosis publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2018.02.016 contributor: fullname: Schuliga – volume: 14 start-page: 2122 issue: 11 year: 2016 ident: 10.1016/j.ejphar.2019.172875_bib57 article-title: Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system publication-title: J. Thromb. Haemost. doi: 10.1111/jth.13494 contributor: fullname: Wolter – volume: 181 start-page: 254 issue: 3 year: 2010 ident: 10.1016/j.ejphar.2019.172875_bib50 article-title: Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.200810-1615OC contributor: fullname: Sisson – volume: 1 start-page: 1935 issue: 9 year: 2003 ident: 10.1016/j.ejphar.2019.172875_bib3 article-title: Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts publication-title: J. Thromb. Haemost. doi: 10.1046/j.1538-7836.2003.00363.x contributor: fullname: Bachli – volume: 369 start-page: 1964 issue: 20 year: 2013 ident: 10.1016/j.ejphar.2019.172875_bib28 article-title: Asthma and coagulation publication-title: N. Engl. J. Med. doi: 10.1056/NEJMcibr1311045 contributor: fullname: Lambrecht – volume: 312 start-page: L772 issue: 5 year: 2017 ident: 10.1016/j.ejphar.2019.172875_bib43 article-title: Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity publication-title: Am. J. Physiol. Lung Cell Mol. Physiol. doi: 10.1152/ajplung.00553.2016 contributor: fullname: Schuliga – volume: 171 start-page: 1180 issue: 5 year: 2014 ident: 10.1016/j.ejphar.2019.172875_bib18 article-title: Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease publication-title: Br. J. Pharmacol. doi: 10.1111/bph.12544 contributor: fullname: Hollenberg – volume: 60 start-page: 3455 issue: 11 year: 2009 ident: 10.1016/j.ejphar.2019.172875_bib10 article-title: Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts publication-title: Arthritis Rheum. doi: 10.1002/art.24935 contributor: fullname: Bogatkevich – volume: 14 start-page: 429 issue: 10 year: 2008 ident: 10.1016/j.ejphar.2019.172875_bib12 article-title: Factor Xa: at the crossroads between coagulation and signaling in physiology and disease publication-title: Trends Mol. Med. doi: 10.1016/j.molmed.2008.08.001 contributor: fullname: Borensztajn – volume: 121 start-page: 33 year: 2017 ident: 10.1016/j.ejphar.2019.172875_bib21 article-title: p300 and C/EBPβ-regulated IKKβ expression are involved in thrombin-induced IL-8/CXCL8 expression in human lung epithelial cells publication-title: Pharmacol. Res. doi: 10.1016/j.phrs.2017.04.020 contributor: fullname: Huang – volume: 8 start-page: 1366 issue: 6 year: 2014 ident: 10.1016/j.ejphar.2019.172875_bib30 article-title: Effects of factor Xa on the expression of proteins in femoral arteries from type 2 diabetic patients publication-title: Br. J. Clin. Pharmacol. doi: 10.1111/bcp.12469 contributor: fullname: López-Farré – volume: 22 start-page: 5847 issue: 12 year: 2018 ident: 10.1016/j.ejphar.2019.172875_bib45 article-title: Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts publication-title: J. Cell Mol. Med. doi: 10.1111/jcmm.13855 contributor: fullname: Schuliga – volume: 37 start-page: 10 issue: 1 year: 2014 ident: 10.1016/j.ejphar.2019.172875_bib4 article-title: Serum analysis of coagulation factors in IPF and NSIP publication-title: Inflammation doi: 10.1007/s10753-013-9706-z contributor: fullname: Bargagli – volume: 179 start-page: 64 year: 2014 ident: 10.1016/j.ejphar.2019.172875_bib24 article-title: Cardiolipin asymmetry, oxidation and signaling publication-title: Chem. Phys. Lipids doi: 10.1016/j.chemphyslip.2013.11.010 contributor: fullname: Kagan – volume: 26 start-page: 41 issue: 1 year: 2019 ident: 10.1016/j.ejphar.2019.172875_bib48 article-title: Cell biology of activated protein C publication-title: Curr. Opin. Hematol. doi: 10.1097/MOH.0000000000000473 contributor: fullname: Shahzad – volume: 159 start-page: 1383 issue: 4 year: 2001 ident: 10.1016/j.ejphar.2019.172875_bib19 article-title: Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)62525-4 contributor: fullname: Howell – volume: 130 start-page: 302 issue: 1 year: 2006 ident: 10.1016/j.ejphar.2019.172875_bib25 article-title: Anticoagulant therapy and idiopathic pulmonary fibrosis publication-title: Chest doi: 10.1378/chest.130.1.302-a contributor: fullname: Kinder |
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Snippet | There is growing evidence for the contribution of the activated coagulation factor X (FXa) in the development of chronic inflammatory lung diseases. Therefore,... |
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SubjectTerms | Activated clotting factor X Apoptosis Human lung epithelial cells Inflammatory signaling Mitochondrial dysfunction Protease-activated receptors “Biased” effects of GB83 |
Title | Activated clotting factor X mediates mitochondrial alterations and inflammatory responses via protease-activated receptor signaling in alveolar epithelial cells |
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