Chronic and acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia

• Published in: Blood Vol. 125; no. 10; pp. 1653 - 1661
• Main Authors: Bernaudin, Françoise, Verlhac, Suzanne, Arnaud, Cécile, Kamdem, Annie, Vasile, Manuela, Kasbi, Florence, Hau, Isabelle, Madhi, Fouad, Fourmaux, Christine, Biscardi, Sandra, Epaud, Ralph, Pondarré, Corinne
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.03.2015
• Subjects: Acute Disease; Adolescent; Anemia - blood; Anemia - complications; Anemia, Sickle Cell - blood; Anemia, Sickle Cell - complications; Anemia, Sickle Cell - genetics; Blood Flow Velocity; Carotid Artery, Internal; Carotid Stenosis - complications; Carotid Stenosis - diagnosis; Carotid Stenosis - physiopathology; Cerebral Infarction - diagnosis; Cerebral Infarction - etiology; Child; Child, Preschool; Chronic Disease; Cohort Studies; Female; Humans; Infant; Infant, Newborn; Longitudinal Studies; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Risk Factors; Young Adult
• ISSN: 0006-4971; 1528-0020; 1528-0020
• DOI: 10.1182/blood-2014-09-599852

Early transcranial Doppler (TCD) screening of the Créteil sickle cell anemia (SCA)-newborn cohort, and rapid initiation of transfusion programs, resulted in successful prevention of overt strokes, but a high cumulative risk of silent cerebral infarcts (SCI) remained, suggesting that TCD screening do...