Diazepam withdrawal: effects of diazepam and gepirone on acoustic startle-induced 22 kHz ultrasonic vocalizations

• Published in: Psychopharmacology Vol. 114; no. 1; p. 101
• Main Authors: Vivian, J A, Farrell, W J, Sapperstein, S B, Miczek, K A
• Format: Journal Article
• Language: English
• Published: Germany 01.02.1994
• Subjects: Acoustic Stimulation; Analgesics - pharmacology; Animals; Anti-Anxiety Agents - pharmacology; Body Temperature - drug effects; Body Weight - drug effects; Diazepam - adverse effects; Diazepam - pharmacology; Dose-Response Relationship, Drug; Male; Muscle Relaxants, Central - pharmacology; Pain Measurement - drug effects; Pyrimidines - pharmacology; Rats; Reflex, Startle - drug effects; Substance Withdrawal Syndrome - psychology; Vocalization, Animal - drug effects

It has proven difficult to demonstrate and study the "anxiogenic" quality of drug withdrawal states in animals. Ultrasonic vocalizations (USV) in response to acoustic startle stimuli have shown promise as a measure of affect and may represent "distress" responses during diazepam...