Inverse relationship between body mass index and mitochondrial oxidative phosphorylation capacity in human subcutaneous adipocytes

• Published in: American journal of physiology: endocrinology and metabolism Vol. 309; no. 4; pp. E380 - E387
• Main Authors: Fischer, Britta, Schöttl, Theresa, Schempp, Christina, Fromme, Tobias, Hauner, Hans, Klingenspor, Martin, Skurk, Thomas
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.08.2015
• Subjects: Adipocytes - cytology; Adipocytes - metabolism; Adipocytes - pathology; Adult; Aged; Body Mass Index; Cell Respiration; Cell Size; Cells; Cells, Cultured; Electrodes; Female; Humans; Middle Aged; Mitochondria; Mitochondria - metabolism; Obesity; Oxidative Phosphorylation; Phosphorylation; Subcutaneous Fat - cytology; Subcutaneous Fat - metabolism; Subcutaneous Fat - pathology; Young Adult; adipocytes; obesity; oxidative phosphorylation; respiratory chain complexes; mitochondrial respiration

Obesity is characterized by a substantial increase in adipose tissue that may contribute to energy balance. Recently, obesity was suggested to be associated with impaired mitochondrial function in adipocytes. In this study, we investigated the following: 1) the respiratory capacities of mitochondria...