Magnesium sulfate provides neuroprotection in lipopolysaccharide-activated primary microglia by inhibiting NF-κB pathway

• Published in: The Journal of surgical research Vol. 184; no. 2; pp. 944 - 950
• Main Authors: Gao, Feng, MD, Ding, Baozhong, MD, Zhou, Longan, MD, Gao, Xueshan, MD, Guo, Huiguang, MD, Xu, Hong, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2013
• Subjects: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology; Animals; Calcium Channel Agonists - pharmacology; Calcium Channels, L-Type - drug effects; Calcium Channels, L-Type - physiology; Cells, Cultured; Dinoprostone - metabolism; Dose-Response Relationship, Drug; Inflammation; Inflammation - chemically induced; Inflammation - physiopathology; Inflammation - prevention & control; Interleukin-1beta - metabolism; L-type calcium channels; Lipopolysaccharides; Lipopolysaccharides - adverse effects; Lipopolysaccharides - pharmacology; Magnesium sulfate; Magnesium Sulfate - pharmacology; Magnesium Sulfate - therapeutic use; Microglia; Microglia - cytology; Microglia - drug effects; Microglia - physiology; Models, Animal; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; NF-kappa B; NF-kappa B - antagonists & inhibitors; NF-kappa B - drug effects; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - metabolism; Rats; Rats, Sprague-Dawley; Signal Transduction - drug effects; Signal Transduction - physiology; Surgery; Tumor Necrosis Factor-alpha - metabolism; Magnesium sulfate; Inflammation; NF-kappa B; L-type calcium channels; Microglia; Lipopolysaccharides

Abstract Background Magnesium sulfate has been used as an anticonvulsant in severe preeclamptic or eclamptic women prior to surgical trauma, but its effects on neuroinflammation is not well defined. In the present study, we investigated the neuroprotective effects of magnesium sulfate in lipopolysac...