The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model

• Published in: Biochimica et biophysica acta Vol. 1862; no. 6; pp. 1093 - 1104
• Main Authors: Valenti, Daniela, de Bari, Lidia, de Rasmo, Domenico, Signorile, Anna, Henrion-Caude, Alexandra, Contestabile, Andrea, Vacca, Rosa Anna
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2016
• Subjects: Adenosine Triphosphate - metabolism; AMPK; Animals; Antioxidants - therapeutic use; Catechin - analogs & derivatives; Catechin - therapeutic use; Cell Proliferation - drug effects; Cells, Cultured; Disease Models, Animal; Down syndrome; Down Syndrome - drug therapy; Down Syndrome - metabolism; Down Syndrome - physiopathology; Female; Hippocampus - cytology; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - physiopathology; Male; Mice; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial bioenergetics; Mitochondrial biogenesis; Neural Stem Cells - cytology; Neural Stem Cells - drug effects; Neural Stem Cells - metabolism; Neural Stem Cells - pathology; Neurogenesis - drug effects; Neuroprotective Agents - therapeutic use; Nutraceuticals; PGC-1α; Protein Kinases - metabolism; Resveratrol - therapeutic use; HK; mtDNA; Mitochondrial bioenergetics; OLIGO; OXPHOS; FCCP; TMPD; T-FAM; DS; ASC; HOVA; Mitochondrial biogenesis; NRF-1; wt; gDNA; Nutraceuticals; AA; CC; Ap5A; SUCC; DCF; EGCG; SOD; PGC-1α; CN; ROS-ds; Down syndrome; DCFH-DA; RSV; G6P-DH; GLU/MAL; NPCs; ROT; ROS; POX; AMPK; AICAR; GAPDH; BrdU; PGC-1 α; MRC

Mitochondrial dysfunctions critically impair nervous system development and are potentially involved in the pathogenesis of various neurodevelopmental disorders, including Down syndrome (DS), the most common genetic cause of intellectual disability. Previous studies from our group demonstrated impai...