The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model - Valenti, Daniela; de Bari, Lidia; de Rasmo, Domenico; Signorile, Anna; Henrion-Caude, Alexandra; Contestabile, Andrea; Vacca, Rosa Anna (Biochimica et biophysica acta, 2016)
Keywords: Adenosine Triphosphate - metabolism; AMPK; Animals; Antioxidants - therapeutic use; Catechin - analogs & derivatives; Catechin - therapeutic use; Cell Proliferation - drug effects; Cells, Cultured; Disease Models, Animal; Down syndrome; Down Syndrome - drug therapy; Down Syndrome - metabolism; Down Syndrome - physiopathology; Female; Hippocampus - cytology; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - physiopathology; Male; Mice; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial bioenergetics; Mitochondrial biogenesis; Neural Stem Cells - cytology; Neural Stem Cells - drug effects; Neural Stem Cells - metabolism; Neural Stem Cells - pathology; Neurogenesis - drug effects; Neuroprotective Agents - therapeutic use; Nutraceuticals; PGC-1α; Protein Kinases - metabolism; Resveratrol - therapeutic use; HK; mtDNA; Mitochondrial bioenergetics; OLIGO; OXPHOS; FCCP; TMPD; T-FAM; DS; ASC; HOVA; Mitochondrial biogenesis; NRF-1; wt; gDNA; Nutraceuticals; AA; CC; Ap5A; SUCC; DCF; EGCG; SOD; PGC-1α; CN; ROS-ds; Down syndrome; DCFH-DA; RSV; G6P-DH; GLU/MAL; NPCs; ROT; ROS; POX; AMPK; AICAR; GAPDH; BrdU; PGC-1 α; MRC