Leukocyte adhesion, edema, and development of postischemic capillary no-reflow

• Published in: The American journal of physiology Vol. 267; no. 4 Pt 2; p. H1329
• Main Authors: Jerome, S N, Akimitsu, T, Korthuis, R J
• Format: Journal Article
• Language: English
• Published: United States 01.10.1994
• Subjects: Analysis of Variance; Animals; Capillaries - drug effects; Capillaries - physiology; Capillaries - physiopathology; Cell Adhesion; Dogs; Edema - physiopathology; Edema - prevention & control; Female; Hindlimb - blood supply; Hypertonic Solutions; Ischemia - pathology; Ischemia - physiopathology; Ischemia - prevention & control; Leukocytes - drug effects; Leukocytes - physiology; Male; Mice; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - physiology; Muscle, Smooth, Vascular - physiopathology; Muscles - blood supply; Muscles - pathology; Neutrophils - physiology; Phalloidine - pharmacology; Reference Values; Regional Blood Flow

The aim of this study was to determine whether the formation of edema that occurs secondary to the neutrophil-dependent increase in microvascular permeability contributes to the genesis of no-reflow in postischemic skeletal muscle. To address this issue, four experimental approaches were used. In th...