Diesel particulate matter2.5 promotes epithelial-mesenchymal transition of human retinal pigment epithelial cells via generation of reactive oxygen species

• Published in: Environmental pollution (1987) Vol. 262; p. 114301
• Main Authors: Lee, Hyesook, Hwang-Bo, Hyun, Ji, Seon Yeong, Kim, Min Yeong, Kim, So Young, Park, Cheol, Hong, Su Hyun, Kim, Gi-Young, Song, Kyoung Seob, Hyun, Jin Won, Choi, Yung Hyun
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2020
• Subjects: Epithelial-mesenchymal transition (EMT); Particulate matter (PM); Reactive oxygen species (ROS); Retinal pigment epithelial (RPE) cells; Transforming growth factor-β (TGF- β); Retinal pigment epithelial (RPE) cells; Transforming growth factor-β (TGF- β); Epithelial-mesenchymal transition (EMT); Particulate matter (PM); Reactive oxygen species (ROS)

Although several studies have linked PM2.5 (particulate matter with a diameter less than 2.5 μm) to ocular surface diseases such as keratitis and conjunctivitis, very few studies have previously addressed its effect on the retina. Therefore, the aim of this study was to evaluate the effect of PM2.5...