A methanol extract and N,N-dimethyltryptamine from Psychotria viridis Ruiz & Pav. inhibit Zika virus infection in vitro

• Published in: Archives of virology Vol. 166; no. 12; pp. 3275 - 3287
• Main Authors: Moraes, Thaís F. S., Ferraz, Ariane C., da Cruz Nizer, Waleska S., Tótola, Antônio H., Soares, Débora B. S., Duarte, Lucienir P., Vieira-Filho, Sidney A., Magalhães, Cintia L. B., de Magalhães, José C.
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.12.2021; Springer Nature B.V
• Subjects: Anti-inflammatory agents; Antiviral activity; Antiviral agents; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Antiviral drugs; antiviral properties; Biomedical and Life Sciences; Biomedicine; Brazil; Drug development; Fetuses; Humans; Infections; Infectious Diseases; Inflammation; Medical Microbiology; Methanol; monitoring; N,N-Dimethyltryptamine - therapeutic use; Neurological complications; Original Article; Plant Extracts - pharmacology; Psychotria; Psychotria viridis; Public health; Virology; Viruses; Zika Virus; Zika Virus Infection - drug therapy; Brazil

Zika virus (ZIKV) is a public health problem due to its association with serious fetal and neurological complications and the lack of antiviral agents and licensed vaccines against this virus. Surveillance studies have alerted about the potential occurrence of a new South American epidemic episode d...