The Warburg effect and mitochondrial oxidative phosphorylation: Friends or foes?

• Published in: Biochimica et biophysica acta. Bioenergetics Vol. 1864; no. 1; p. 148931
• Main Authors: Martins Pinto, M., Paumard, P., Bouchez, C., Ransac, S., Duvezin-Caubet, S., Mazat, J.P., Rigoulet, M., Devin, A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2023
• Subjects: Adenosine Triphosphate - metabolism; Cancer; Cell Respiration; Glycolysis; Humans; Mitochondria; Mitochondria - metabolism; Oxidative Phosphorylation; Warburg effect; Mitochondria; Oxidative phosphorylation; Warburg effect; Cancer

Cancer cells display an altered energy metabolism, which was proposed to be the root of cancer. This early discovery was done by O. Warburg who conducted one of the first studies of tumor cell energy metabolism. Taking advantage of cancer cells that exhibited various growth rates, he showed that can...