Preclinical evaluation of [225Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms

• Published in: European journal of nuclear medicine and molecular imaging Vol. 48; no. 11; pp. 3408 - 3421
• Main Authors: Tafreshi, Narges K., Pandya, Darpan N., Tichacek, Christopher J., Budzevich, Mikalai M., Wang, Zhen, Reff, Jordan N., Engelman, Robert W., Boulware, David C., Chiappori, Alberto A., Strosberg, Jonathan R., Ji, Haitao, Wadas, Thaddeus J., El-Haddad, Ghassan, Morse, David L.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2021; Springer Nature B.V
• Subjects: Alpha rays; Animal models; Animals; Cardiology; Dosimeters; Dosimetry; Humans; Imaging; Injection; Intravenous administration; Lung Neoplasms - drug therapy; Lungs; Lutetium isotopes; Medicine; Medicine & Public Health; Mice; Mice, Inbred BALB C; Mice, SCID; Neoplasia; Neoplasms; Nephropathy; Neuroendocrine tumors; Nuclear Medicine; Octreotide - therapeutic use; Octreotide - toxicity; Oncology; Organometallic Compounds - therapeutic use; Organometallic Compounds - toxicity; Original Article; Orthopedics; Pharmacokinetics; Purity; Radiochemistry; Radioisotopes; Radiology; Radiopharmaceuticals - therapeutic use; Radiopharmaceuticals - toxicity; Route selection; Solid tumors; Somatostatin; Somatostatin receptors; Stability; Synthesis; Tissue Distribution; Toxicity; Toxicity testing; Translational research; Tumors; Ac targeted alpha therapy; Ac]Ac-DOTA-TATE; Lung neuroendocrine neoplasms; [; 225Ac targeted alpha therapy; [225Ac]Ac-DOTA-TATE

Purpose There is significant interest in the development of targeted alpha-particle therapies (TATs) for treatment of solid tumors. The metal chelator-peptide conjugate, DOTA-TATE, loaded with the β-particle emitting radionuclide 177 Lu ([ 177 Lu]Lu-DOTA-TATE) is now standard care for neuroendocrine...