Design, synthesis and anti-influenza virus activity of furan-substituted spirothiazolidinones

• Published in: Bioorganic chemistry Vol. 112; p. 104958
• Main Authors: Apaydın, Çağla Begüm, Tansuyu, Merve, Cesur, Zafer, Naesens, Lieve, Göktaş, Füsun
• Format: Journal Article
• Language: English
• Published: SAN DIEGO Elsevier Inc 01.07.2021; Elsevier
• Subjects: Antiviral activity; Biochemistry & Molecular Biology; Chemistry; Chemistry, Organic; Furan; İnfluenza virus; Life Sciences & Biomedicine; Physical Sciences; Science & Technology; Spirothiazolidinone; Synthesis; Spirothiazolidinone; Furan; İnfluenza virus; Synthesis; Antiviral activity; INFLUENZA; Influenza virus

[Display omitted] •New N-(3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives were synthesized.•Compounds 3c and 3d had superior activity against influenza A/H3N2 virus.•Spirothiazolidinone moiety is important for antiviral activity. A new series of N-(3-oxo-1-thia-4-azaspiro[4.5]decan-4-...