Harmful Effects of Inorganic Mercury Exposure on Kidney Cells: Mitochondrial Dynamics Disorder and Excessive Oxidative Stress

• Published in: Biological trace element research Vol. 200; no. 4; pp. 1591 - 1597
• Main Authors: Han, Biqi, Lv, Zhanjun, Han, Xuemin, Li, Siyu, Han, Bing, Yang, Qingyue, Wang, Xiaoqiao, Wu, Pengfei, Li, Jiayi, Deng, Ning, Zhang, Zhigang
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2022; Springer Nature B.V
• Subjects: Biochemistry; Biological stress; Biomedical and Life Sciences; Biotechnology; Body organs; cell lines; Cell viability; cytotoxicity; Damage accumulation; Dynamics; Epithelial cells; Epithelial Cells - metabolism; Epithelium; HEK293 Cells; Humans; In vitro methods and tests; industry; Kidney - metabolism; Kidneys; Life Sciences; Lymphocytes; Lymphocytes T; Mercuric chloride; Mercury; Mercury - metabolism; Mitochondria; Mitochondrial Diseases - metabolism; Mitochondrial Dynamics; Molecular modelling; Nutrition; Oncology; Organs; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism; Pollution; Receptors; Signal transduction; SIRT1 protein; Sirtuin 1 - metabolism; T-lymphocytes; Toxicity; trace elements; Sirt1/PGC-1α; HgCl; Mitochondrial dynamics dysfunction; Kidney cell; ROS; HgCl2

Mercury is widely used in industry and has caused global environmental pollution. Inorganic mercury accumulates in the body causes damage to many organs, and the kidney is the most susceptible to the toxic effects of mercury. However, the underlying specific molecular mechanism of renal injury induc...